A5050306126- Cardiovascular Function and Risk Factors
- Congenital Heart Disease Studies
- Pulmonary Hypertension Research and Treatments
- Cardiac Imaging and Diagnostics
- T-cell and B-cell Immunology
- Diabetes and associated disorders
- Immune Cell Function and Interaction
- Cardiovascular Issues in Pregnancy
- Pancreatic function and diabetes
- Cardiac pacing and defibrillation studies
- Nuclear Structure and Function
- Kawasaki Disease and Coronary Complications
- Coronary Artery Anomalies
- Immune Response and Inflammation
- Cardiovascular Health and Disease Prevention
- Vascular anomalies and interventions
- Cardiomyopathy and Myosin Studies
- CAR-T cell therapy research
- Cardiovascular Disease and Adiposity
- Hematopoietic Stem Cell Transplantation
- Cardiac Valve Diseases and Treatments
- PARP inhibition in cancer therapy
- RNA Research and Splicing
- Mechanical Circulatory Support Devices
- Congenital Anomalies and Fetal Surgery
Boston Children's Hospital
2019-2025
Harvard University
2014-2025
Sapienza University of Rome
2022-2024
Boston Children's Museum
2020-2023
GlaxoSmithKline (Belgium)
2019
Vita-Salute San Raffaele University
2009-2014
Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele
2014
Istituti di Ricovero e Cura a Carattere Scientifico
2014
San Raffaele University of Rome
2010-2011
The San Raffaele Telethon Institute for Gene Therapy
2009-2011
OBJECTIVE Autoimmune diseases, including type 1 diabetes, are thought to have a Th17-cell bias and/or T-regulatory cell (Treg) defect. Understanding whether this is hallmark of patients with diabetes crucial question that still unsolved, largely due the difficulties accessing tissues targeted by disease. RESEARCH DESIGN AND METHODS We phenotypically and functionally characterized Th17 cells Tregs residing in pancreatic-draining lymph nodes (PLNs) 19 63 nondiabetic donors those circulating...
FOXP3(+) regulatory T (Treg) cells enforce immune self-tolerance and homeostasis, variation in some aspects of Treg function may contribute to human autoimmune diseases. Here, we analyzed population-level variability by performing genome-wide expression profiling CD4(+) conventional (Tconv) from 168 donors, healthy or with established type-1 diabetes (T1D) type-2 (T2D), relation genetic immunologic screening. There was a range signature transcripts, almost invariant, others more variable,...
Cardiac manifestations in multisystem inflammatory syndrome children (MIS-C) occur ∼80% of patients. Left ventricular (LV) systolic dysfunction is the most frequent cardiac finding.In this single-centre, retrospective cohort study, we report on detailed assessment LV function MIS-C patients using strain and rate analysis. We compare those with normal peak z-scores (both longitudinal circumferential strain) to abnormal (decreased and/or strain).Among 25 patients, 14 (56%) were male, 20 (80%)...
ABSTRACT Objectives Early prenatal detection of congenital heart disease (CHD) allows mothers to plan for their pregnancy and delivery; however, the effect certain sociodemographic fetal factors on care has not been investigated thoroughly. This study evaluated impact maternal characteristics timing diagnosis CHD postnatal outcomes. Methods retrospective multicenter cohort included women with a echocardiographic between 2010 2019. Women were grouped into quartiles social vulnerability...
The human commensal Staphylococcus aureus (SA) is a leading cause of skin/soft tissue and surgical-site infections, bacteremia. Functional antibodies T-cell-mediated immunity, particularly Th1/Th17 responses, are thought to mediate protection. Vaccine development may be hindered by modulation vaccine-induced T cells pathogen-activated immunoregulatory e.g., via IL-10.We screened SA proteins for CD4+ T-cell-activating IL-10/IL-17-inducing capacities using healthy donor-derived PBMCs....
Abstract Background Strain and synchrony can be calculated from a variety of software packages, but there is paucity data with inter-vendor comparisons in children. To test the hypothesis that different packages may affect results, independent acquisition, we compared values obtained using two commercially available analysis tool (QLAB TomTec), several settings. Methods The study population included 108 children; patients were divided into three groups: (1) normal cardiac structure...
utchinson-Gilford Progeria Syndrome (HGPS) is an ultra-rare premature aging disorder that affects multiple organ systems, but cardiovascular complications are the most frequent cause of death. 1,2onsequently, characterizing manifestations in patients with HGPS particular interest.In prior work, diastolic dysfunction, valve calcification, and left ventricular (LV) hypertrophy were identified as structural functional cardiac abnormalities, whereas LV ejection fraction was preserved patients....
Accurate measurement of ventricular volumes is an important clinical imaging goal. Three-dimensional echocardiography (3DEcho) used increasingly as it more available and less costly than cardiac magnetic resonance (CMR). For the right ventricle (RV), current practice to acquire 3DEcho from apical view. However, in some patients RV may be better seen subcostal Therefore, this study compared volume measurements vs. view, using CMR a reference standard.Patients <18 years old undergoing...
This study aimed to describe the histomorphologic characteristics of resected (unroofed) common wall tissue from repair anomalous aortic origin a coronary artery and determine whether histologic features correlate with clinical imaging findings.
The right ventricle (RV) has complex geometry and function, with motion along three separate axes-longitudinal, radial, anteroposterior. Quantitative assessment of RV function by two-dimension echocardiography (2DE) been limited as a consequence this complexity, whereas newer dimensional (3D) analysis offers the potential for more comprehensive contributors to function. aims study were quantify longitudinal, radial anteroposterior components global using 3D in cohort healthy children examine...
Abstract Background Three‐dimensional echocardiography (3DE) evaluation of left ventricular (LV) volume and function in pediatrics compares favorably with cardiac magnetic resonance imaging. The aim this study was to establish from a multicenter, normal pediatric z‐score values 3DE volumes function. Methods Six hundred ninety‐eight healthy children (ages 0–18 years) were recruited five centers. LV acquired the 4‐chamber view. A vendor‐independent software analyzed end‐diastolic (EDV),...
Tregs are attractive candidates for clinical modulation of excessive immune responses. In SCT mouse models, the adoptive transfer purified natural has been shown to prevent GvHD, while sparing a significant GvL effect. Tregs' suppressor function demonstrated be critically dependent on IL-2, therefore cyA significantly reduces allostimulated Tregs. To address role in human SCT, we focused calcineurin inhibitor-free GvHD prophylaxis. We tested this hypothesis haploidentical peripheral blood...
Background: Adolescents and young adults with hypertrophic cardiomyopathy (HCM) persistent left ventricular outflow tract obstruction (LVOTO) have larger atrial volume (LAV) abnormal diastolic function (LA) strain compared to those without resting LVOTO. It is unknown whether intermittent LVOTO exercise results in smaller LAV improved LA indices Methods: All HCM patients echo stress echocardiography (ESE) from 2014-2022 at a single center were enrolled. The cohort was divided into 3 ESE...