A5110573784- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac and Coronary Surgery Techniques
- Aortic aneurysm repair treatments
- Mechanical Circulatory Support Devices
- Cardiovascular Function and Risk Factors
- Cardiac Arrest and Resuscitation
- Hemodynamic Monitoring and Therapy
- Aortic Disease and Treatment Approaches
- Cardiomyopathy and Myosin Studies
- Cardiac Health and Mental Health
- Acute Myocardial Infarction Research
- Healthcare Quality and Management
- Transplantation: Methods and Outcomes
- Thermal Regulation in Medicine
- Cardiac Structural Anomalies and Repair
- Disaster Response and Management
- Surgical Simulation and Training
- Pain Management and Treatment
- Cardiovascular Disease and Adiposity
- Health Systems, Economic Evaluations, Quality of Life
- Cardiovascular Issues in Pregnancy
- Simulation-Based Education in Healthcare
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Patient Safety and Medication Errors
- Congenital Heart Disease Studies
Boston Children's Hospital
2021-2024
Boston Children's Museum
2023-2024
Stanford University
1995-2004
Stanford Medicine
2002-2004
Philadelphia University
2003
San Francisco VA Medical Center
1997-2002
Duke Medical Center
2002
Cleveland Foundation
2002
Cleveland Clinic
2002
University of Pennsylvania
2002
Acute changes in cerebral function after elective coronary bypass surgery are a difficult clinical problem. We carried out multicenter study to determine the incidence and predictors of — use resources associated with perioperative adverse neurologic events, including injury.
Background: Acute changes in renal function after elective coronary bypass surgery are incompletely characterized and represent a challenging clinical problem. Objective: To determine the incidence characteristics of postoperative dysfunction failure, perioperative predictors dysfunction, effect failure on in-hospital resource utilization patient disposition discharge. Design: Prospective, observational, multicenter study. Setting: 24 university hospitals. Patients: 2222 patients having...
Background and Purpose —Cerebral injury after cardiac surgery is now recognized as a serious costly healthcare problem mandating immediate attention. To effect solution, those subgroups of patients at greatest risk must be identified, thereby allowing efficient implementation new clinical strategies. No such subgroup has been identified; however, undergoing intracardiac are thought to high risk, but comprehensive data regarding specific impact on cost, discharge disposition not available....
Background The use of target-controlled infusions anesthetics for coronary artery bypass graft surgery has not been studied in detail. effects propofol or sufentanil, supplemented by sufentanil midazolam, respectively, were evaluated and compared. Methods At 14 clinical sites, 329 patients given a infusion (n = 165) to produce effect-site concentration (Ce) > 3-micrograms/ml 164). Sufentanil also infused. Systolic hypertension, hypotension, tachycardia, bradycardia assessed measuring...
Adult survivors of Hodgkin lymphoma (HL) are at increased risk cardiovascular (CV) events secondary to mediastinal radiation therapy (RT).In this group patients, we assessed the association between cardiopulmonary exercise testing (CPET), as determined by percent-predicted peak Vo2 (ppVo2peak), and clinical outcomes, well rate ppVo2peak decline sex differences.All HL who were >10 years post chest RT underwent ≥1 CPET enrolled from a single center. Traditional CV treatment factors, along with...
The leading cause of mortality in adult populations throughout the world is atherosclerosis, which results cardiovascular and cerebrovascular complications consumes substantive health care resources. impact atherosclerosis on patients undergoing surgery also considerable, given multiple stresses occurring during, especially following, surgical procedures, thereby precipitating vascular morbidity. Perioperative morbidity occur approximately 10% 600,000 who undergo cardiac annually, consuming...
Background: In adults with hypertrophic cardiomyopathy (HCM), left ventricular outflow tract (LVOT) obstruction and reduced atrial strain (LAS) predict heart failure cardiac event risk. However, data in children are limited. Hypothesis: LVOT gradient LAS together determine outcome risk young HCM. Methods: All HCM patients exercise stress echocardiography (ESE) from 2014-2022 at a single center were included. Patients stratified by gradients: Group 1 (n=44, rest/exercise gradients <...
Hypothermia permitted the advent of cardiac surgery and is considered by many mainstay cerebral protection during cardiopulmonary bypass (CPB). How ever, some clinicians have questioned importance reduced temperatures CPB advocate "normo thermic" heart surgery. (mild, moderate, profound) provides periods inadequate oxygen delivery at least two mecha nisms. First, metabolic rate directly related to tempera ture ; therefore, increase toler ance delivery. Q 10 values (the ratio rates...
perfusion flow rate and gas up to 8.5 L/min each, as well increasing the FIO2 100%, did not improve SvO2. Subsequent decrease of SvO2, generalized shivering was observed, suspected cause this complication. A supplementary dose pancuronium, 0.2 mg/kg, administered, shwering dissipated, SVO2, PaO2, PaCO2 returned control values (Table 1). The whole-body oxygen consumption (VO2) computed product arterial-venous content difference multiplied by flow: VO 2 (mL/min) = {[(SAO2% - SVO2%) x Hb 1 36]...
Neurologische Funktionsstörungen sind nach Eingriffen am Herzen mit kardiopulmonalem Bypass keine Seltenheit: So treten bei bis zu 70 % aller Patienten zumindest leichte kognitive Einschränkungen auf. Als Ursachen werden u. a. entzündliche Vorgänge diskutiert. Systemische inflammatorische Veränderungen offenen Herzeingriffen durch das chirurgische Trauma und den Kontakt des Bluts der künstlichen Oberfläche Bypasses schon länger bekannt. Ob ähnliche Prozesse auch im ZNS nachweisbar sind,...
Background: Adolescents and young adults with hypertrophic cardiomyopathy (HCM) persistent left ventricular outflow tract obstruction (LVOTO) have larger atrial volume (LAV) abnormal diastolic function (LA) strain compared to those without resting LVOTO. It is unknown whether intermittent LVOTO exercise results in smaller LAV improved LA indices Methods: All HCM patients echo stress echocardiography (ESE) from 2014-2022 at a single center were enrolled. The cohort was divided into 3 ESE...
Historically, morbidity and mortality have been the primary outcome measures in coronary artery bypass research. Limited health care resources led to greater emphasis on cost as a mea sure. These are each important measures, but they fail directly assess what patients about, which is their overall quality of life (QOL). When QOL used an medical research, it should encompass at minimum following domains: physical status, mental function, social interaction, disease-specific measure....
Anesthesia and the Cardiac Patient. Anesthesiology Clinics of North America, Vol. 21, No. 5. Nussmeier NA, ed. Philadelphia: W.B. Saunders, 2003. ISBN 0889-8537. 246 pp, $162 annual subscription for 4 issues. The specialty practice cardiovascular anesthesia (CV) has evolved substantially over last 5 years. With advent drug-eluding coronary stents waning popularity off-pump CABG procedures, anesthesiologist is increasingly unlikely to care a ‘healthy’ patient scheduled open-coronary...