A5032038257- Congenital Heart Disease Studies
- Cardiac Valve Diseases and Treatments
- Neonatal and fetal brain pathology
- Cardiovascular Function and Risk Factors
- Congenital heart defects research
- Aortic Disease and Treatment Approaches
- Advanced MRI Techniques and Applications
- Coronary Artery Anomalies
- Cardiac Imaging and Diagnostics
- Pulmonary Hypertension Research and Treatments
- Atomic and Subatomic Physics Research
- Cardiac Arrhythmias and Treatments
- Spaceflight effects on biology
- Tryptophan and brain disorders
- Cardiac Structural Anomalies and Repair
- Kawasaki Disease and Coronary Complications
- Mitochondrial Function and Pathology
- Birth, Development, and Health
- Treatment of Major Depression
- Cardiomyopathy and Myosin Studies
- Congenital Diaphragmatic Hernia Studies
- Eosinophilic Disorders and Syndromes
- Tracheal and airway disorders
- Hemodynamic Monitoring and Therapy
- Cardiovascular and Diving-Related Complications
Boston Children's Hospital
2021-2024
Harvard University
2021-2024
Children's Hospital Colorado
2022-2024
University of Colorado Denver
2022-2024
University of Colorado Anschutz Medical Campus
2022-2023
Children's National
2015-2021
Boston Children's Museum
2021
National Research Institute
2020
Abstract Patients with congenital heart disease often have cardiac anatomy that deviates significantly from normal, frequently requiring multiple surgeries. Image segmentation a preoperative cardiovascular magnetic resonance (CMR) scan would enable creation of patient-specific 3D surface models the heart, which potential to improve surgical planning, simulation, and allow automatic computation quantitative metrics function. However, there is no publicly available CMR dataset for whole-heart...
Compared with acyanotic congenital heart disease (CHD), cyanotic CHD has an increased risk of lifelong mortality and morbidity. These adverse outcomes may be attributed to delayed cardiomyocyte maturation, since the transition from a hypoxic fetal milieu oxygen-rich postnatal environment is disrupted. We established rodent model replicate myocardial conditions spanning perinatal development, tested hypothesis that chronic hypoxia impairs cardiac development. Pregnant mice were housed in...
Introduction As the life expectancy of children with congenital heart disease (CHD) is rapidly increasing and adult population CHD growing, there an unmet need to improve clinical workflow efficiency analysis. Cardiovascular magnetic resonance (CMR) a noninvasive imaging modality for monitoring patients CHD. CMR exam based on multiple breath-hold 2-dimensional (2D) cine acquisitions that should be precisely prescribed expert institution dependent. Moreover, 2D images have relatively thick...
Preliminary evidence suggests perturbations of the kynurenine pathway (KP) tryptophan metabolism in infants with single ventricle heart disease (SVHD). In 72 SVHD undergoing stage 2 palliation (S2P) and 41 controls, we quantified serum KP metabolite concentrations via tandem mass spectroscopy pre-S2P post-S2P at 2, 24, 48 h assessed relationships outcomes (length stay, hypoxemia burden, intubation duration). Pre-S2P, had lower serotonin levels higher kynurenic acid, 3-hydroxykynurenine,...
Background Reduced oxygen delivery in congenital heart disease causes delayed brain maturation and white matter abnormalities utero. No treatment currently exists. Tetrahydrobiopterin (BH4) is a cofactor for neuronal nitric oxide synthase. BH4 availability reduced upon NOS activation, such as during hypoxic conditions, leads to toxin production. We hypothesize that levels are depleted the replacement therapy mitigates toxic effects of hypoxia on matter. Methods Results Transgenic mice were...
Some patients with pulmonary atresia an intact ventricular septum (PA/IVS) or a left ventricle dominant atrioventricular canal defect (LDAVC) hypoplastic right (RV) and univentricular (1 V) circulation may be candidates for conversion to either complete biventricular (2 repair one-and-a-half (1.5 V). We sought identify pre-operative cardiovascular magnetic resonance (CMR) findings associated successful from 1V 1.5V 2V circulation. In this single center retrospective study, subjects PA/IVS...
Abstract Aims Coarctation of the aorta is associated with long-term morbidity including decreased exercise capacity, despite successful repair. In absence discrete recoarctation, haemodynamic mechanism remains unknown. This multicentre study evaluated relationship between shape, flow, and capacity in patients after arch repair, specifically through lens aortic size mismatch descending (DAo) flow their association exercise. Methods results Cardiac magnetic resonance, cardiopulmonary test,...
Heterotaxy syndrome (HS) is often associated with complex congenital heart disease (CHD). While fetal echocardiography (FE) permits accurate prenatal identification of most CHD, the high level complexity in HS may pose challenges predicting postnatal findings and outcomes. This study aimed to define accuracy FE anatomy, physiology, surgical management CHD setting HS.Retrospective single-center cohort including all patients a diagnosis from 2003 2018. Anatomic diagnoses reports were compared...
Children with single ventricle heart disease typically require a series of three operations, (1) Norwood, (2) Glenn, and (3) Fontan, which ultimately results in complete separation the pulmonary systemic circuits to improve pulmonary/systemic circulation. In last stage, Fontan operation, inferior vena cava (IVC) is connected arteries (PAs), allowing remainder deoxygenated blood passively flow circuit. It hypothesized that optimizing anatomy would lead decreased power loss more balanced...
Motivation: Individual pulmonary vascular resistances (PVR) of the left and right lung are needed to perform in-silico virtual cardiac surgery improve Fontan conduit designs, yielding more balanced blood flow lungs. Goal(s): Predict patient-specific PVR both lungs using clinical pressure data acquired from cardiovascular magnetic resonance exams catheterizations. Approach: Utilize computational fluid dynamics (CFD) lumped parameter (LP) models iteratively optimize Results: There is excellent...
Motivation: There is currently limited data examining longitudinal changes in hemodynamics and vascular properties Fontan patients living at altitude. Goal(s): We aimed to assess hemodynamic parameters vessel morphology a single high-altitude surgical center correlations between these post-Fontan outcomes. Approach: retrospectively reviewed undergoing operation from 1999 2021. analyzed cardiac magnetic resonance imaging catheterization. Results: Our findings highlight flow, pressure, area....
Introduction: Reduced oxygen delivery in complex congenital heart disease (CHD) can lead to brain white matter (WM) injury utero. Currently, no treatment exists. Tetrahydrobiopterin (BH4) is a cofactor for neuronal nitric oxide synthase, and its absence, toxic peroxynitrite production favored. Hypoxia activates which reduces BH4 availability. Hypothesis: Decreased levels underlie WM the fetus with CHD, will reduce this injury. Methods: Mice were divided into three groups: normoxic controls...
Introduction: Cardiovascular magnetic resonance (CMR) imaging is recommended for surveillance and risk stratification in patients with hypertrophic cardiomyopathy (HCM), but the role of CMR findings clinical decision making has not been described a pediatric population. Methods: In this single center retrospective study we identified all HCM who underwent CMR. We then determined if there was management change based on findings. Results: 136 an diagnosis from 2005-2022. Of these, 55 (40%) 76...
Background: Infants with single ventricle heart disease (SVHD) have perturbed kynurenine pathway (KP) function prior to stage 2 palliation. Buildup of kynurenic acid—a byproduct this pathway—is linked worse outcomes post 2. To date, perturbations along the entire KP not been delineated in SVHD infants at time operation. Methods: This is a center prospective cohort study 75 undergoing palliation and 50 controls. Targeted analysis metabolites was performed on serum samples via tandem mass...