A5039245100- Hematopoietic Stem Cell Transplantation
- Acute Myeloid Leukemia Research
- CAR-T cell therapy research
- Acute Lymphoblastic Leukemia research
- Immune Cell Function and Interaction
- Virus-based gene therapy research
- Chronic Myeloid Leukemia Treatments
- T-cell and B-cell Immunology
- Polyomavirus and related diseases
- CRISPR and Genetic Engineering
- Cytomegalovirus and herpesvirus research
- COVID-19 Clinical Research Studies
- Chronic Lymphocytic Leukemia Research
- Antifungal resistance and susceptibility
- Neutropenia and Cancer Infections
- Renal Transplantation Outcomes and Treatments
- SARS-CoV-2 and COVID-19 Research
- Fungal Infections and Studies
- Immunotherapy and Immune Responses
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Antibiotic Resistance in Bacteria
- Renal and related cancers
- CNS Lymphoma Diagnosis and Treatment
- Mesenchymal stem cell research
- COVID-19 and healthcare impacts
Vita-Salute San Raffaele University
2016-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2016-2025
Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele
2014-2025
San Raffaele University of Rome
2010-2024
IRCCS Ospedale San Raffaele
2022-2023
Università Cattolica del Sacro Cuore
2020
University of Basel
2019
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2019
University of Milan
2019
Laboratoire d’immunologie intégrative du cancer
2017
Antigen exposure and differentiation phenotype influence long-term persistence of memory T cells after hematopoietic stem cell transplant.
T cell receptor (TCR)–based therapy has the potential to induce durable clinical responses in patients with cancer by targeting intracellular tumor antigens high sensitivity and promoting survival. However, need for TCRs specific shared oncogenic manufacturing protocols able redirect specificity while preserving fitness remain limiting factors. By longitudinal monitoring of functionality dynamics 15 healthy donors, we isolated 19 Wilms’ antigen 1 (WT1), which is overexpressed several types....
Unlike other cases of acute leukemia, the diagnosis T-cell lymphoblastic leukemia/lymphoma (T-ALL/LBL) is uniquely based on morphology and flow cytometry. Although genomic background has been broadly uncovered, large spectrum genes involved variability molecular mechanisms underlying gene deregulation have delayed introduction cytogenetics into diagnostic flowcharts. To overcome these limitations implement a genetic T-ALL/LBLs, we repurpose whole transcriptome expression assay (WTEa) as...
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Background: Although the outcome of allogeneic hematopoietic stem cell transplantation (allo-HSCT) has dramatically improved in past decade, it is still compromised by transplant-related mortality (TRM), mainly caused Graft-versus-Host Disease (GvHD). Methods: We conducted a prospective observational study to ascertain potential serum interleukin-6 (IL6) levels, measured before conditioning and 7 days after allo-HSCT, predicting acute GvHD, TRM survival allo-HSCT with Post-Transplant...
Despite allogeneic hematopoietic stem cell transplant (allo-HCT) and the development of novel FLT3 inhibitors in both induction (midostaurin) relapsed/refractory setting (gilteritinib), FLT3-ITD mutated leukemia (FLT3-ITD+ AML) still represents a challenge for modern hematology. Sorafenib is, to this date, only inhibitor that demonstrated efficacy improving progression-free overall survival as post-HCT maintenance therapy, even if its use has not been approved so far by regulatory agencies....
Invasive fungal diseases (IFDs) still represent a relevant cause of mortality in patients affected by hematological malignancies, especially acute myeloid leukaemia (AML) and myelodysplastic syndrome (MDS) undergoing remission induction chemotherapy, allogeneic hematopoietic stem cell transplantation (allo-HSCT) recipients. Mold-active antifungal prophylaxis (MAP) has been established as standard care. However, breakthrough IFDs (b-IFDs) have emerged significant issue, particularly invasive...
Among major unmet needs in allogeneic stem cell transplantation (HSCT), the identification of a suitable donor, control infection complications (where cytomegalovirus [CMV] is paradigmatic), and reduction both disease relapse graft-versus-host (GVHD) represent 4 key challenges.[11][12][13] A recent CIBMTR (Center for International Blood Marrow Transplant Research) study showed how PTCy was associated with higher incidence CMV infection, regardless donor type.Moreover, reactivation abrogation...
Correlation between risk of graft-versus-host disease (GvHD) and CD3+ counts within the peripheral blood stem cell graft has recently been reported in setting post-transplant cyclophosphamide (PT-Cy). We aimed to investigate benefit addition a single dose anti-T lymphocyte globulin (ATLG 5 mg/kg) PT-Cy this setting. Starting 2019, all patients receiving PBSC transplant containing above 300 × 106/kg (study group) received ATLG standard PT-Cy. The study was designed as real-life analysis...
To evaluate the retinal circulation in patients with active acute leukemia, to correlate perfusion metrics systemic laboratory values, and assess vascular after leukemia remission.Longitudinal study of 22 eyes from 12 leukemia; healthy were recruited as control subjects. All underwent optical coherence tomography angiography at baseline. Optical was repeated case morphologic remission.Patients' age ranged 37 74 years. participants had a 20/20 vision. In all leukemic eyes, detected...