A5041787690- Hematopoietic Stem Cell Transplantation
- Acute Lymphoblastic Leukemia research
- Acute Myeloid Leukemia Research
- Renal Transplantation Outcomes and Treatments
- Immune Cell Function and Interaction
- Polyomavirus and related diseases
- Transplantation: Methods and Outcomes
- Lung Cancer Diagnosis and Treatment
- Cytomegalovirus and herpesvirus research
- Liver Disease Diagnosis and Treatment
- Medical Imaging and Pathology Studies
- COVID-19 Clinical Research Studies
- T-cell and B-cell Immunology
- Chronic Myeloid Leukemia Treatments
- Lymphoma Diagnosis and Treatment
- CAR-T cell therapy research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Metabolism and Genetic Disorders
- Blood properties and coagulation
- Blood groups and transfusion
- Oral and gingival health research
- Metabolism, Diabetes, and Cancer
- Pneumothorax, Barotrauma, Emphysema
- Liver Disease and Transplantation
- COVID-19 and healthcare impacts
Istituti di Ricovero e Cura a Carattere Scientifico
2018-2025
Vita-Salute San Raffaele University
2016-2025
Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele
2019-2025
IRCCS Ospedale San Raffaele
2019-2024
Ospedale Maggiore
2004
Ospedale Infermi di Rimini
1993
Background: Although the outcome of allogeneic hematopoietic stem cell transplantation (allo-HSCT) has dramatically improved in past decade, it is still compromised by transplant-related mortality (TRM), mainly caused Graft-versus-Host Disease (GvHD). Methods: We conducted a prospective observational study to ascertain potential serum interleukin-6 (IL6) levels, measured before conditioning and 7 days after allo-HSCT, predicting acute GvHD, TRM survival allo-HSCT with Post-Transplant...
Post-transplant cyclophosphamide (PTCy) has emerged as a promising graft-versus-host disease (GvHD) prophylaxis in allogeneic hematopoietic stem cell transplantation (allo-HSCT). However, no studies have reported the efficacy of GvHD based on PTCy with sirolimus (Sir-PTCy) patients acute myeloid leukemia (AML). In this retrospective study, we analyze use combination PTCy, or without mycophenolate mofetil (MMF), 242 consecutive adult AML undergoing myeloablative first allo-HSCT from different...
Among major unmet needs in allogeneic stem cell transplantation (HSCT), the identification of a suitable donor, control infection complications (where cytomegalovirus [CMV] is paradigmatic), and reduction both disease relapse graft-versus-host (GVHD) represent 4 key challenges.[11][12][13] A recent CIBMTR (Center for International Blood Marrow Transplant Research) study showed how PTCy was associated with higher incidence CMV infection, regardless donor type.Moreover, reactivation abrogation...
Sinusoidal Obstruction Syndrome (SOS) is a life threatening HSCT complication and it can rapidly evolve in Multiple Organ Dysfunction Syndrome, with mortality exceeding 80%. Early treatment defibrotide the leading factor for efficacy. Its prophylactic use recommended pediatric setting, but its value isn't validated adults, although factors individual risk assessment are debated. We here present real-world experience of Defibrotide prophylaxis adults at very high SOS. treated Ursodeoxycholic...
Introduction Reducing toxicities while preserving efficacy in allogeneic stem cell transplant (allo-HCT) remains a particularly challenging problem. Different strategies to enhance the antitumor activity without increasing early and late adverse of conditioning regimens have been investigated. Methods The aim “AlloTreo” prospective phase 2 clinical trial was evaluate safety regimen based on Treosulfan (42 g/m ) fludarabine ( https://clinicaltrials.gov/ct2/show/NCT00598624 ). We enrolled 108...
Invasive fungal diseases (IFDs) are a leading cause of infection-related-mortality after allogeneic hematopoietic stem cell transplantation (HSCT). In this prospective pilot study, we investigated the use bedside lung ultrasound (US) in IFD management. Ten consecutive hematological patients, who developed pulmonary HSCT, were included study. Standard computed tomography scan and US performed at diagnosis 10 days antifungal treatment. The demonstrated high sensitivity detection lesions...
We describe the case of a 45-year-old man affected by T-cell acute lymphoblastic leukaemia and diagnosed with COVID-19 early after an allogeneic haematopoietic stem cell transplant. The infectious disease was characterised severe prolonged course, further complicated spontaneous pneumomediastinum pneumopericardium. successfully treated this patient antiviral drug remdesivir associated two courses convalescent plasma. This report represents good example typical clinical course in severely...
Autoimmune diseases (ADs) represent a heterogeneous group of conditions affecting 5–10% the global population. In recent decades, hematopoietic stem cell transplant (HSCT), mainly autologous, has been successfully adopted to treat patients affected by severe/refractory ADs. this context malnutrition detrimental impact on relapse, mortality, infection rate, engraftment, long-term survival, and prolongation hospitalization. However, in population, management nutrition should be improved since...