A5002125483- Gut microbiota and health
- Diabetes and associated disorders
- Clostridium difficile and Clostridium perfringens research
- Helicobacter pylori-related gastroenterology studies
- Gastrointestinal motility and disorders
- Tryptophan and brain disorders
- Diet, Metabolism, and Disease
- Digestive system and related health
- Immune Response and Inflammation
- Diabetes Management and Research
Vita-Salute San Raffaele University
2019-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2019-2025
Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele
2019-2023
IRCCS Ospedale San Raffaele
2019
Significance Functional loss of gut barrier integrity with subsequent increased antigen trafficking and occurrence low-grade intestinal inflammation precede the onset type 1 diabetes (T1D) in patients preclinical models, thus suggesting that these events are mechanistically linked to autoimmune pathogenesis disease. However, a causal relationship between permeability was never demonstrated. Our data show breakage continuity leads activation islet-reactive T cells intestine, triggering...
Introduction The integrity of the gut barrier (GB) is fundamental to regulate crosstalk between microbiota and immune system prevent inflammation autoimmunity at intestinal level but also in organs distal from such as pancreatic islets. In support this idea, we recently demonstrated that breakage GB leads activation islet-reactive T cells triggers autoimmune Type 1 Diabetes (T1D). T1D patients NOD mice, spontaneous model diabetes, there are alterations specifically affect structure...
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Background: in preclinical models of Type 1 Diabetes (T1D) the integrity gut barrier (GB) is instrumental to avoid dysregulated crosstalk between commensal microbiota and immune cells prevent autoimmunity. The GB composed intestinal epithelial (IEB) mucus layer containing mucins antimicrobial peptides (AMPs) that are crucial maintain tolerance. In T1D alterations primarly affects layer. human increased permeability IEB damage have been demonstrated but was never assessed.Methods: We...
Abstract Recent evidence suggests that the intestinal environment and, specifically, modifications of microbiome profile, regulate pathogenesis extra-intestinal autoimmune diseases such as Type 1 Diabetes (T1D) by inducing inflammation and increasing gut permeability. Although low-grade alterations barrier integrity are found in humans animal models T1D, a direct causal link between enteropathy triggering beta cell autoimmunity is yet to be established. Here we show breakage (by low-dose DSS...