A5050946209- Inflammatory Bowel Disease
- Gut microbiota and health
- IL-33, ST2, and ILC Pathways
- Viral gastroenteritis research and epidemiology
- Genomics and Chromatin Dynamics
- Chromosomal and Genetic Variations
- Eosinophilic Esophagitis
- Spaceflight effects on biology
- Anorectal Disease Treatments and Outcomes
- Helicobacter pylori-related gastroenterology studies
- Clostridium difficile and Clostridium perfringens research
- Mycobacterium research and diagnosis
- Muscle metabolism and nutrition
- Diverticular Disease and Complications
- Climate Change and Health Impacts
- Microscopic Colitis
- Air Quality and Health Impacts
- Eosinophilic Disorders and Syndromes
- Geomagnetism and Paleomagnetism Studies
- Energy and Environment Impacts
- Animal Virus Infections Studies
- Genomic variations and chromosomal abnormalities
- Atomic and Subatomic Physics Research
- Plant Virus Research Studies
- Genetics, Aging, and Longevity in Model Organisms
Humanitas University
2020-2023
IRCCS Humanitas Research Hospital
2021-2023
Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele
2022-2023
Istituti di Ricovero e Cura a Carattere Scientifico
2022-2023
Vita-Salute San Raffaele University
2022-2023
IRCCS Ospedale San Raffaele
2022
Inflammatory bowel disease (IBD) is a class of chronic disorders whose etiogenesis still unknown. Despite the high number IBD-related omics studies, RNA-sequencing data produced results that are hard to compare because experimental variability and different analysis approaches. We here introduce IBD Transcriptome Metatranscriptome Meta-Analysis (TaMMA) framework, comprehensive survey publicly available datasets. TaMMA an open-source platform where scientists can explore simultaneously freely...
Eosinophilic esophagitis (EoE) is a chronic immune-mediated rare disease, characterized by esophageal dysfunctions. It likely to be primarily activated food antigens and classified as disease for most patients. Therefore, deeper understanding of the pathogenetic mechanisms underlying EoE needed implement improve therapeutic lines intervention ameliorate overall patient wellness.
Ulcerative colitis (UC) is a chronic inflammatory disorder of unknown aetiology. Gut virome dysbiosis fundamental in UC progression, although its role the early phases disease far from fully understood. Therefore, we sought to investigate virome-associated protein encoded by
Abstract Within the chromatin, distal elements interact with promoters to regulate specific transcriptional programs. Histone acetylation, interfering net charges of nucleosomes, is a key player in this regulation. Here, we report that oncoprotein SET critical determinant for levels histone acetylation within enhancers. We disclose condition which accumulated, severe Schinzel-Giedion Syndrome (SGS), characterized by failure usage regulatory regions typically employed during fate commitment....
Abstract Microgravity-induced bone loss is a major concern for space travelers. Ground-based microgravity simulators are crucial to study the effect of exposure on biological systems and address limitations posed by restricted access real space. In this work, first time, we adopt multidisciplinary approach characterize morphological, biochemical, molecular changes underlying response human marrow stromal cells long-term simulated during osteogenic differentiation. Our results show that...
Airborne ultrafine particle (UFP) exposure is a great concern as they have been correlated to increased cardiovascular mortality, neurodegenerative diseases and morbidity in occupational environmental settings. The components of diesel exhaust particles (DEPs) represent about 25% the emission mass; these surface area consequently high capacity adsorb toxic molecules, then transported throughout body. Previous in-vivo studies indicated that DEP increases pro- antioxidant protein levels...
Lay Summary The JAK/STAT inhibitor tofacitinib, recently approved for the treatment of ulcerative colitis, is found to modulate intestinal endothelial barrier functions in directing leukocyte adhesion and transmigration colitis patients displaying high levels STAT3/STAT6 phosphorylation.
Abstract Inflammatory bowel disease (IBD) is a class of chronic inflammatory gut disorders whose aetiogenesis still unknown. Despite the high number omics studies, RNA sequencing (RNA-Seq) data produced for better IBD pathogenesis understanding cannot be compared because experimental variability and different analysis approaches. To overcome this hurdle, we here introduce open-source Transcriptome Metatranscriptome Meta-Analysis (TaMMA) framework, comprehensive survey publicly available...
Background: in preclinical models of Type 1 Diabetes (T1D) the integrity gut barrier (GB) is instrumental to avoid dysregulated crosstalk between commensal microbiota and immune cells prevent autoimmunity. The GB composed intestinal epithelial (IEB) mucus layer containing mucins antimicrobial peptides (AMPs) that are crucial maintain tolerance. In T1D alterations primarly affects layer. human increased permeability IEB damage have been demonstrated but was never assessed.Methods: We...
Abstract Microgravity induced bone loss is a major concern for space travellers. Ground-based microgravity simulators are crucial to study the effect of exposure on biological systems and address limitations posed by restricted access real space. In this work, first time we adopt multidisciplinary approach characterize morphological, biochemical, molecular changes underlying response human marrow stromal cells long-term simulated during osteogenic differentiation. Our results show that...
SUMMARY Within the chromatin, distal elements interact with promoters to regulate specific transcriptional programs. Histone acetylation, interfering net charges of nucleosomes, is a key player in this regulation. Here, we report that onco-protein SET critical determinant for levels histone acetylation within enhancers. We disclose conditions which accumulated, including severe Schinzel-Giedion Syndrome (SGS), are characterized by failure usage regulatory regions typically employed during...