Fabio Giannone
A5039760888- Pancreatic and Hepatic Oncology Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Liver Disease Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Neuroendocrine Tumor Research Advances
- Gallbladder and Bile Duct Disorders
- Pancreatitis Pathology and Treatment
- Renal cell carcinoma treatment
- Lung Cancer Research Studies
- Organ Transplantation Techniques and Outcomes
- Colorectal Cancer Treatments and Studies
- Renal Transplantation Outcomes and Treatments
- Hepatitis B Virus Studies
- Hepatitis C virus research
- 3D Printing in Biomedical Research
- Liver Disease and Transplantation
- Neuroblastoma Research and Treatments
- Gastric Cancer Management and Outcomes
- Radiomics and Machine Learning in Medical Imaging
- Intestinal Malrotation and Obstruction Disorders
- Cardiac, Anesthesia and Surgical Outcomes
- Pediatric Hepatobiliary Diseases and Treatments
- Cancer Cells and Metastasis
- Colorectal and Anal Carcinomas
Hôpital Civil, Strasbourg
2021-2025
Université de Strasbourg
2021-2025
Hôpitaux Universitaires de Strasbourg
2021-2025
Inserm
2021-2024
Azienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo
2024
Institute for Translational Medicine and Liver Disease
2022-2024
Institut de Chirurgie Guidée par l'Image
2021-2024
Azienda Sanitaria Locale Alessandria
2024
Institut de Recherche contre les Cancers de l’Appareil Digestif
2022-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2015-2023
Preoperative portal vein embolization (PVE) is currently the standard technique used routinely to increase size of future remnant liver (FRL) before major hepatectomies. The degree hypertrophy (DH) approximatively 10% and requires on average six weeks. ALPPS faster achieves a good DH but with higher morbidity mortality. One method recently proposed FRL venous deprivation (LVD), its clinical operative impact still unknown. aim this study compare intra- postoperative morbidity/mortality...
To assess the association between neoadjuvant therapy and overall survival (OS) in patients with left-sided resectable pancreatic cancer (RPC) compared to upfront surgery. Left-sided is associated worse OS right-sided cancer. Although currently seen as not effective RPC, current randomized trials included mostly RPC. International multicenter retrospective study including consecutive after resection for pathology-proven either or surgery 76 centers from 18 countries on 4 continents...
To identify risk factors for conversion, develop a predictive Conversion Risk Score (CRS), and assess the association between conversion severe postoperative complications. occurs in 15-30% of minimally invasive left pancreatectomies (MILP). potential negative impacts on outcomes are poorly described. Retrospective, nationwide, multicenter study including all MILP (laparoscopy robot) performed 2010 2021. were identified by multivariate mixed model, CRS was developed "training-set" validated...
Objective: To determine the accuracy of preoperative imaging, including contrast-enhanced computed tomography (CE-CT), endoscopic ultrasound (EUS), and 68 Gallium-DOTATOC positron emission ( Ga-DOTATOC PET), in identifying nodal metastases (N+) sporadic nonfunctioning pancreatic neuroendocrine tumors (NF-PanNETs). Background: An accurate identification N+ NF-PanNETs is critical for surgical planning. The different imaging techniques detecting lymph node (LN) has been poorly investigated....
<b><i>Background/Aims:</i></b> The annual incidence of pancreatic neuroendocrine tumors (PanNET) has been estimated to be around 0.8/100,000 inhabitants. aim this study was determine the frequency incidental histological diagnosis PanNET in specimen evaluation for a purpose other than diagnosis. <b><i>Methods:</i></b> One thousand seventy-four histopathological examinations specimens performed 3 centers Italy were retrospectively reviewed. All...
To evaluate whether, in a sample of patients radically treated for colorectal carcinoma, the preoperative determination carcinoembryonic antigen (p-CEA) may have prognostic value and constitute an independent risk factor relation to disease-free survival. The CEA seems be related both staging neoplasia patient's prognosis, although this—to date—has not been conclusively demonstrated is still matter intense debate scientific community. This retrospective analysis prospectively collected data....
Hepatocellular carcinoma is usually detected late and therapeutic options are unsatisfactory. Despite marked progress in patient care, HCC remains among the deadliest cancers world-wide. While surgical resection a key option for early-stage HCC, 5-year survival rates after limited. One reason limited outcomes lack of reliable prognostic biomarkers to predict recurrence. prognosis has been shown correlate with different systemic pathological markers which associated Liver inflammatory...
Hepatocellular carcinoma (HCC) have a dismal prognosis and any effective neoadjuvant treatment has been validated to date. We aimed investigate the role of transarterial chemoembolization (TACE) in upfront resectable HCC larger than 5 cm.
Abstract Hypothermic machine perfusion (HPM) grants a better postoperative outcome in transplantation of organs procured from extended criteria donors (ECDs) and after cardiac death (DCD). So far, the only available parameter for prediction concerning those is pretransplant biopsy score. The aim this study to evaluate whether renal resistance (RR) trend during HPM may be used as predictive marker post‐transplantation outcome. From December 2015 present, HMP has been systematically applied...
Background & Aims Liver chronic co-infection with hepatitis B and D viruses (HBV HDV) is the most aggressive form of viral hepatitis. To date, no treatment allows efficient clearance, a better characterization virus-host interactions required to develop new therapeutic strategies. Methods Using loss-of-function strategies, we validated unexpected proviral activity innate immune-related Janus kinase 1 (JAK1) in HDV life cycle determined its mechanism action on through various functional...
To determine the reproducibility of National Comprehensive Cancer Network (NCCN) resectability status classification for pancreatic cancer.
Ischemia-reperfusion injury during major hepatic resections is associated with high rates of post-operative complications and liver failure. Real-time intra-operative detection dysfunction could provide great insight into clinical outcomes. In the present study, we demonstrate application a novel optical technology, hyperspectral imaging (HSI), to predict short-term outcomes after hepatectomy. We considered fifteen consecutive patients undergoing resection for malignant lesions from January...
Hepatocellular carcinoma (HCC) is a leading cause of death among cirrhotic patients, for which chemopreventive strategies are lacking. Recently, we developed simple human cell-based system modeling clinical prognostic liver signature (PLS) predicting disease progression and HCC risk. In previous study, applied our drug discovery identified captopril, an approved angiotensin converting enzyme (ACE) inhibitor, as candidate compound chemoprevention. Here, explored ACE therapeutic target...