A5058303499- Renal Diseases and Glomerulopathies
- Parathyroid Disorders and Treatments
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Chronic Kidney Disease and Diabetes
- Complement system in diseases
- Healthcare Systems and Public Health
- Vasculitis and related conditions
- Dialysis and Renal Disease Management
- Renal Transplantation Outcomes and Treatments
- Chronic Lymphocytic Leukemia Research
- Systemic Lupus Erythematosus Research
- Acute Kidney Injury Research
- Systemic Sclerosis and Related Diseases
- Genetic Syndromes and Imprinting
- Adenosine and Purinergic Signaling
- Liver Diseases and Immunity
- Magnesium in Health and Disease
- Folate and B Vitamins Research
- Pregnancy and Medication Impact
- Erythropoietin and Anemia Treatment
- Biomedical Research and Pathophysiology
- Hepatitis C virus research
- Renal and Vascular Pathologies
- Hematopoietic Stem Cell Transplantation
- Electrolyte and hormonal disorders
First Pavlov State Medical University of St. Petersburg
2015-2024
Pavlov Institute of Physiology of the Russian Academy of Sciences
2006-2023
University of Bologna
2020
LMU Klinikum
2020
Alexion Pharmaceuticals (United States)
2020
Seoul National University Hospital
2020
Institute of Nephrology of the National Academy of Medical Sciences of Ukraine
2017-2019
Ministry of Health of the Russian Federation
2016-2018
Pharmacology Research Institute
2016
Pediatric Nephrology of Alabama
2014
Ravulizumab is a long-acting C5 inhibitor engineered from eculizumab with increased elimination half-life, allowing an extended dosing interval two to eight weeks. Here we evaluate the efficacy and safety of ravulizumab in adults atypical hemolytic uremic syndrome presenting thrombotic microangiopathy. In this global, phase 3, single arm study complement inhibitor-naïve (18 years older) who fulfilled diagnostic criteria for syndrome, enrolled patients received through 26-week initial...
Anemia associated with chronic kidney disease (CKD) often requires treatment recombinant human erythropoietin (EPO). Hypoxia-inducible factor-prolyl hydroxylase inhibitors (PHIs) stimulate endogenous EPO synthesis and induce effective erythropoiesis by non-EPO effects. GSK1278863 is an orally administered small-molecule PHI.Multicenter, single-blind, randomized, placebo-controlled, parallel-group study.Anemic non-dialysis-dependent patients CKD stages 3-5 (CKD-3/4/5 group; n=70) anemic...
К 50-ЛЕТИЮ РОССИЙСКОГО КАРДИОЛОГИЧЕСКОГО ОБЩЕСТВА 7 КЛИНИЧЕСКИЕ РЕКОМЕНДАЦИИ СЕРДЕЧНО-СОСУДИСТЫЙ РИСК И ХРОНИЧЕСКАЯ БОЛЕЗНЬ ПОЧЕК: СТРАТЕГИИ КАРДИО-НЕФРОПРОТЕКЦИИКомитет экспертов Российского кардиологического общества (РКО), Научного нефрологов России (НОНР), Российской ассоциацией эндокринологов (
IntroductionAtypical hemolytic uremic syndrome (aHUS) is a rare, complex, multisystem disease of dysregulated complement activity, characterized by progressive thrombotic microangiopathy (TMA), acute kidney injury, and multiorgan dysfunction, which often progresses to chronic disease. Results from the prospective clinical trial ravulizumab (NCT02949128) reveal rapid resolution TMA in patients with aHUS, sustained efficacy safety 26-week initial evaluation period.MethodsThe aim this analysis...
This prospective single-arm trial with historic controls evaluated the efficacy and safety of treatment based on a combination rituximab, intravenous cyclophosphamide corticosteroids (RCP) administered at lower cumulative doses for induction early remission in primary membranous nephropathy (PMN).
Early patient referral correlates with improved survival on dialysis. We examine whether early and a planned first dialysis affect quality of life (QoL).All patients commencing in nine centres seven European countries between 1 July 1998 31 October 1999 were recruited.early referral=followed by nephrologist >1 month before (<1 month=late referral); planned=early previous serum creatinine >300 micro mol/l non-urgent (early no or urgent dialysis=unplanned). QoL was measured at 8 weeks using...
Arterial hypertension (AH) is associated with heart and chronic kidney disease (CKD). However, the precise mechanisms of myocardial remodeling (MR) in settings CKD remain elusive. We hypothesized that TRPC6, calcineurin/NFAT, Wnt/β-catenin signaling pathways are involved development MR background AH. Early was induced by performing a 5/6 nephrectomy (5/6NE) spontaneously hypertensive rats (SHR-NE). Sham-operated (SO) SHR (SHR-SO) Wistar Kyoto (WKY-SO) served as controls. Systolic blood...
Type 2 diabetes (DM2) could be reproduced in rats with alimentary obesity by using low doses of streptozotocin (LD-STZ) as well STZ high preliminary nicotinamide (NA) administration. However, induce tubulotoxicity. Aim . To develop rat model DN NA-STZ-induced DM2 and compare it LD-STZ-model order to choose the most relevant approach for reproducing renal glomerular tubular morphofunctional diabetic changes. Starting at 3 weeks after uninephrectomy, adult male Wistar were fed five-week...
Abstract Background Atypical hemolytic uremic syndrome (aHUS) triggered by pregnancy is a rare disease caused dysregulation of the alternative complement pathway that occurs in approximately 1 25,000 pregnancies. The 311 phase 3 trial (NCT02949128) showed ravulizumab, long-acting C5 inhibitor obtained through selective modifications to eculizumab, efficacious inhibiting complement-mediated thrombotic microangiopathy (TMA) patients with aHUS. In this analysis, we report outcomes subgroup from...
In Brief Background Renal transplant glomerulitis (G) is associated with acute antibody-mediated rejection (ABMR) in the presence of donor-specific antibodies. However, long-term prognosis isolated G (isG) absence antibodies or combination T cell–mediated (TCMR) remains unexplored. Methods Seventy recipients were included this retrospective study and subdivided into 3 groups: isG, TCMR (G + TCMR), ABMR. The control groups were: patients Banff type I II without (NR). Kaplan-Meier...
Preeclampsia is a disorder that can occur during pregnancy and one of the leading causes death among pregnant women. This occurs after 20th week characterized by arterial hypertension, proteinuria, fetoplacental, multiple organ dysfunctions. Despite long history studying preeclampsia, its etiology pathogenesis remain poorly understood, therapy symptomatic. One factors believed to be misfolded proteins are prone form amyloid aggregates. The CRD tests, utilizing binding amyloid-specific dye...
The literature review presents the current status of method high-dose immunosuppressive therapy with autologous hematopoietic stem cell transplantation in treatment Crohn’s disease.In recent decades, there has been an increase disease. frequency CD response rate to biopreparations ranges from 20 50%, up 80% patients need surgical treatment. Due insufficient effectiveness therapy, active research is underway for new therapeutic opportunities, one which HDIT-AHSCT. In Russian Federation, are...
National guidelines. Chronic kidney disease: basic principles of screening, diagnosis, prevention and treatment approaches
The initial phases of molecular and cellular maladaptive bone responses in early chronic kidney disease (CKD) remain mostly unknown. We induced mild CKD spontaneously hypertensive rats (SHR) by either causing arterial hypertension lasting six months (sham-operated rats, SO6) or its’ combination with 3/4 nephrectomy two (Nx2 Nx6, respectively). Sham-operated SHRs (SO2) Wistar Kyoto (WKY2) a two-month follow-up served as controls. Animals were fed standard chow containing 0.6% phosphate. Upon...
INTRODUCTION: Renal injury associated with monoclonal gammopathies (MG) is an area of interest practical onconephrology. Prevalence, spectrum and renal outcome as far approaches to treatment in this pathological entity, particularly Russian population, still remain unclear need refinement. AIM: Analysis the prevalence, spectrum, kidney (MG). PATIENTS AND METHODS: Patients MG proven by biopsies from 01.01.2011 till 01.05.2018 were enrolled into one-center prospective study (n=119). Cases...
Background. Paroxysmal nocturnal hemoglobinuria (PNH) is a rare clonal hematopoietic stem cell disorder, characterized by intravascular hemolysis, cytopenia and thrombosis. Diagnostic errors with delayed diagnosis of PNH are often due to the variety clinical presentation lack awareness doctors this disease. Aim. The aim study was characterize spectrum manifestations complexity classical PNH. Materials & Methods. included 150 patients inclusion criteria were: 1) laboratory signs...
To assess the safety and immunogenicity of subcutaneous (SC) HX575 (epoetin-α) in dialysis- nondialysis-dependent adult patients with chronic kidney disease (CKD).