A5032907771- Adolescent Sexual and Reproductive Health
- Systemic Lupus Erythematosus Research
- Child and Adolescent Psychosocial and Emotional Development
- Attachment and Relationship Dynamics
- HIV/AIDS Research and Interventions
- T-cell and B-cell Immunology
- Sexuality, Behavior, and Technology
- Racial and Ethnic Identity Research
- Monoclonal and Polyclonal Antibodies Research
- Early Childhood Education and Development
- Family Dynamics and Relationships
- Career Development and Diversity
- Youth Development and Social Support
- Child Abuse and Trauma
- Gender, Feminism, and Media
- Platelet Disorders and Treatments
- Bone health and osteoporosis research
- Cytokine Signaling Pathways and Interactions
- Bone Metabolism and Diseases
- Bone health and treatments
- Social Media and Politics
- Rheumatoid Arthritis Research and Therapies
- Religion, Spirituality, and Psychology
- Atherosclerosis and Cardiovascular Diseases
- Higher Education Research Studies
Wellesley Centers for Women
2013-2024
Wellesley College
2015-2024
University of California, Los Angeles
2000-2024
Doheny Eye Institute
2024
Asahi General Hospital
2024
Oregon Health & Science University
2024
UCLA Health
2005-2023
Boston College
2003-2007
University of Washington
2005
Institute for Systems Biology
2005
This mixed-methods study examined urban adolescents’ perceptions of gender and racial/ethnic barriers to STEM (science, technology, engineering, mathematics) success, their meaning-making coping regarding these experiences. The sample includes surveys from 1024 high school-aged students interviews 53 students. Logistic analysis showed that higher science aspirations significantly predicted perceived support for girls women in science. Analysis themes microaggressions, responses gender-...
Drawing on developmental contextual theory, the authors examined relationship of perceived barriers and support with school engagement vocational attitudes among 9th-grade urban high students in 2 studies. Study 1 (N = 174) showed that both from family kin were associated youths' commitment to aspirations for success their future careers. 181) replicated extended 1, demonstrating barriers, general perceptions support, kinship behavioral attitudinal indexes engagement, as well career success,...
A previous genome-wide association study conducted in a population of European ancestry identified rs4963128, KIAA1542 single-nucleotide polymorphism (SNP) 23 kb telomeric to IRF7 (the gene for interferon regulatory factor 7 [IRF-7]), be strongly associated with systemic lupus erythematosus (SLE). This was undertaken investigate whether genetic within is risk the development SLE.We genotyped one SNP (rs4963128) and (rs1131665 [Q412R]) an Asian (1,302 cases, 1,479 controls), assess their SLE....
Systemic lupus erythematosus (SLE) is an autoimmune disease with a complex genetic basis that includes susceptibility gene(s) within the chromosome 1q41–1q42 region. Toll-like receptor 5 (TLR5), innate immune for bacterial flagellin, maps to 1q41 and contains common stop codon polymorphism abrogates signaling (allele C1174T) associated increased risk of infection. By using transmission disequilibrium testing in cohort containing 199 affected patients their 75 unaffected siblings 326 parents,...
ABSTRACT BACKGROUND School‐based comprehensive sex education programs can reduce early adolescents' risky sexual behavior. The purpose of this study was to assess the effectiveness a 3‐year program in delaying vaginal for middle school students and whether family component intervention contributes its effectiveness. METHODS This longitudinal evaluation followed cohort 6th graders (N = 2453) through end 8th grade. design used random assignment 24 schools into treatment comparison conditions....
Parents' conversations with teens about sex and relationships can play a critical role in improving teenage reproductive health by reducing teens' risky sexual behavior. However, little is known how teen-parent communication changes from early to middle adolescence parents tailor their address changing development experiences during these periods. In this longitudinal qualitative study, U.S. (
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by various autoantibodies that recognize autoantigens displayed on the surface of cells undergoing apoptosis. The genetic contribution to SLE susceptibility has been widely recognized. We previously reported evidence for linkage human chromosome 1q41–q42 region and have now narrowed it from 15 5 cM in extended sample using multipoint analysis. Candidate genes within this include (a) PARP, poly(ADP-ribose) polymerase,...
This mixed-method study used a grounded theory approach to explore the meanings underlying importance that adolescents attach their racial-ethnic identities. The sample consisted of 923 9th- 12th-grade students from Black, Latino, Asian, and multiracial backgrounds. Thematic findings identified broad range explanations for adolescents' centrality, ranging pride cultural connection ambivalence colorblind attitudes. While groups differed in reported levels few group differences were...
Abstract The combined presence of anti-phospholipid (PL) Ab, including lupus anticoagulants (LAC) and/or anticardiolipin Ab (aCL), and thrombosis is recognized as the antiphospholipid syndrome (APS). LAC are detected an inhibitory effect on PL-restricted in vitro blood coagulation tests, comprised mainly against β2 glycoprotein I prothrombin (PT). Recently, anti-PT (aPT) were found to be associated with by some investigators, although this not confirmed others. Considering that aPT...
Abstract Objective To identify chromosome regions likely to harbor genes that predispose the development of systemic lupus erythematosus (SLE) by analyzing a full genome scan in nuclear families ascertained for siblings with SLE. Methods Approximately 400 multiallelic markers spaced an average 10 cM apart were genotyped multiethnic panel 238 individuals from 62 multiplex SLE having 88 affected sibling pairs and 456 total pairs. Findings analyzed 2 model‐free statistical linkage procedures....
Abstract Objective To test the hypothesis that some antiphospholipid antibodies (aPL) in patients with syndrome (APS) recognize a conformational epitope shared by β 2 ‐glycoprotein I (β GPI; major autoantigen for antibodies) and homologous catalytic domains of several serine proteases (such as thrombin, activated protein C [APC], plasmin) involved hemostasis. Methods We generated 4 new IgG monoclonal aPL (2 screened against GPI, 1 C) from APS patients. The (mAb) were analyzed binding to APC,...
Poor bone health is common in systemic lupus erythematosus (SLE) patients. This study was undertaken to evaluate fracture risks among low-income SLE and nephritis patients compared those without SLE.We performed a cohort for whom there were Medicaid claims 2007-2010, age- sex-matched non-SLE comparators. defined by the presence of ≥3 International Classification Diseases, Ninth Revision codes SLE. Patients with additionally had ≥2 renal disease. The primary outcome measure pelvis, wrist,...
To explore extended-family sexuality communication and compare it with parent communication.
Abstract Objective Six recent genome scans of different systemic lupus erythematosus (SLE) multiplex family cohorts showed multiple putative susceptibility loci. In the present study, we examined 4 previously identified loci to replicate findings significant linkage 1q23 and 16q12, support suggestive 14q21‐23 20p12 in a cohort 115 multiethnic nuclear families containing 145 SLE‐affected sibpairs. Methods Model‐free, multipoint analyses (SIBPAL2, SAGE version 4.0) exclusion mapping...
This study examined Chinese American youths' perceptions of their non-Asian peers' views and behaviors toward them. In 4 focus groups, 22 Americans (ages 11 to 15) described specific relational experiences that were analyzed thematically. Three major themes related racial discrimination emerged: (1) descriptions stereotyping experiences; (2) harassment or discriminatory (3) meaning-making explanations why occur. These data can help guide future research on Asian peer relationships gain...
ABSTRACT BACKGROUND Early sexual activity can undermine adolescents' future school success and health outcomes. The purpose of this study was to assess the role a family homework component comprehensive sex education intervention in delaying initiation for early adolescents explore what social contextual factors prevent from completing these activities. METHODS This mixed methods included 6th‐ 7th‐grade survey responses 706 students at 11 middle schools receiving intervention, as well...
Background Treatment decision-making regarding immunosuppressive therapy is challenging for individuals with lupus. We assessed the effectiveness of a decision aid in lupus nephritis. Methods and findings In United States multicenter, open-label, randomized controlled trial (RCT), adult women nephritis, mostly from racial/ethnic minority backgrounds low socioeconomic status (SES), seen in- or outpatient settings, were to an individualized, culturally tailored, computerized versus American...
Abstract Objective To evaluate familiality of 15 clinical and laboratory features in systemic lupus erythematosus (SLE)–affected sibpairs, to estimate correlations with the age at SLE diagnosis affected sibpairs parent–offspring pairs. Methods Concordance rates sibling risk ratios were used as indicators for manifestations SLE. Pearson's paired t ‐tests compare Results Increased (1.9–3.9) thrombocytopenia, discoid rash, neurologic disorder (defined seizure or psychosis), hemolytic anemia...
In this study, we examine whether a nine-lesson sex education intervention, “ Get Real: Comprehensive Sex Education That Works,” implemented in sixth grade, can reduce the number of adolescents who might otherwise become “early starters” sexual activity (defined as heterosexual intercourse) by seventh grade. Participants were 548 boys and 675 girls completed surveys both grade (baseline) (follow-up). The sample was 35% Latino, 32% Black, 24% White, 3% Asian, 6% biracial. Students randomly...