A5009198463- Dialysis and Renal Disease Management
- Systemic Lupus Erythematosus Research
- Complement system in diseases
- Electrolyte and hormonal disorders
- Renal Diseases and Glomerulopathies
- Nephrotoxicity and Medicinal Plants
- Renal Transplantation Outcomes and Treatments
- Acute Kidney Injury Research
- Trace Elements in Health
- Vasculitis and related conditions
- Hepatitis C virus research
- Pancreatitis Pathology and Treatment
- Multiple Myeloma Research and Treatments
- Organ and Tissue Transplantation Research
- Lipoproteins and Cardiovascular Health
- Blood groups and transfusion
- Transplantation: Methods and Outcomes
- Vitamin D Research Studies
- Drug Transport and Resistance Mechanisms
- IgG4-Related and Inflammatory Diseases
- Atherosclerosis and Cardiovascular Diseases
- Peripheral Neuropathies and Disorders
- Neurological and metabolic disorders
- Global Maternal and Child Health
- Heart Failure Treatment and Management
Medical University of Varna
2006-2018
University Hospital St. Marina
2014-2016
University of Thessaly
2004
RWTH Aachen University
1997-2002
Introduction Systemic lupus erythematosus (SLE) is a systemic autoimmune disease that can affect substantially any organ in the body. One of its most severe manifestations nephritis. Hereditary C1q deficiency strongly related to SLE but there are very few and inconsistent studies exploring single nucleotide polymorphisms (SNPs) gene cluster relation pathogenesis SLE. In present study we evaluated possible association variants complement with susceptibility nephritis Bulgarian population,...
In patients on chronic hemodialysis hypotensive episodes are frequently encountered during the course of treatment and prevalence atherosclerosis is increased. Endothelin-1 (ET-1), an endothelium-derived peptide with vasoconstrictive mitogenic effects smooth muscles, involved in vascular tone regulation pathogenesis atherosclerosis. The aim present study was to investigate plasma ET-1 explore probable influence pre-existing hypertension. Forty-seven (21 females, mean age 62 ± 12 years) were...
SUMMARY Purpose: To determine and compare the vitamin D status of different groups CKD patients on hemodialysis, peritoneal dialysis, or no renal replacement therapy to evaluate effect therapy. Patients Methods: This pilot study enrolled 40 consecutive (21 men, 19 women) divided into three groups: 15 in 1,2,3,4 stage disease without (RRT); 10CKD hemodialysis (HD) dialysis (PD), ten which were Vitamin was determined by serum 25xydroxyvitamin (25OHD).
Balkan nephropathy (BN) is an endemic disease, which leads to end‐stage renal failure and artificial replacement therapy. Pathologically it characterized by progressive interstitial nephritis in a large population of villages situated the proximity bend Danube up distance 100 km from river several parts Bulgaria, Romania, former Yugoslavia. The urinary proteins 19 patients with BN region Vratza, Bulgaria were examined using ultrathin layer sodium dodecyl sulfate (SDS) pore‐graduated...
Bacterial contamination of dialysis fluid has long been recognized as a problem in hemodialyis. Cytokines released consequence contaminated are believed to be responsible for many acute and chronic side effects patients undergoing renal replacement therapy. For several years now, attempts have made eliminate pyrogenic substances ensure sterile endotoxin-free fluid. A recent filter known DIASAFE®, containing membrane based on Polysulfone® (Fresenius), was tested period 1,000 hours (approx. 14...
Introduction : Lupus nephritis (LN) is a serious complication of the systemic lupus erythematosus (SLE). Anti-C1q antibodies correlate with occurrence and high clinical activity LN, especially proliferative LN. The first reported anti-C1q recognized autoepitopes within collagen-like region (CLR) C1q. Recently we have found autoantibodies against globular C1q domain (gC1q antibodies) in LN patients. aim present study was to evaluate potential pathological consequences presence anti-gC1q...
Wilson`s disease (hepatolenticular degeneration) is an autosomal recessive dis or der of copper transport. It characterized by the accumulation in liver and subsequently other organs, mainly central nervous system kidneys because a deficiency copper-binding protein ceruloplasmin. The gene for has been mapped to chromosome 13 at q14 region. approximate homozygote prevalence 1 30,000 (13,16). Scripta Scientifica Medica 2007; 39(2):143-145
Introduction: Inflammatory myofibroblastic tumour (IMT) is a rare condition which includes proliferation of myofibroblasts accompanied with inflammatory infiltrates. It known to have wide age range and affect both males females. Although its most common site the lungs, IMT also has extrapulmonary locations often include bladder rarely kidneys. Its biological nature varies from completely benign malignant fatal outcome. Material Methods: We report case 61-year-old woman, admitted hospital...
Calciphylaxis is a rare, often fatal, systemic disorder characterized by deposition (precipitation) of calcium hosphate salts (calcification) in the medial layer arteries and soft tissues. Calcification media followed fibrous hyperplasia intima with obliteration lumen tissue ischemia, necrosis, gangrene. The first description calciphylaxis was published 1962. occurs patients end stage renal disease. Almost all reported were on dialysis. Scripta Scientifica Medica 2007;39(1):49-51
Hyperuricemia is a condition characterized by elevated levels of serum uric acid (SUA) in the blood. It chronic metabolic disorder due to purine metabolism disorders that may be primary or induced other pathogenetic disorders. an important risk factor for development cardiovascular (CHD) and kidney disease (CKD). The meta-analysis two studies with adjusted assessments indicates hyperuricemia independently associated increased peripheral neuropathy patients type 2 diabetes. decrease SUA...
Malignant p lasmacytoma (MP) ( m ultiple yeloma) is a clonal B cell disease affecting slow-release plasmatic cells accompanied by monoclonal paraprotein production followed lytic bone lesions. Nearly 50% of the newly diagnosed patients have reduced glomerular filtration rate and about 9% require dialysis treatment due to severe renal impairment. The aim this study direct nephrologists ` attention seek ing diagnosing with unclear fast progression CKD highly sensitive methods proving...
Hyper cholesterolemia and the resulting atherosclerosis has been a major problem for past few decades. Adequate control of serum cholesterol levels is generally achieved by dietary modifications and/or drug regimens. However some patients, particularly those with familial hyper cholesterolemia, fail to respond. Additional treatment methods may be necessary reduce LDL safer in these individuals who are at high risk atherosclerotic disease complications. Reduction lipoproteins Lp(a), oxidation...
Nowadays the number of patients with chronic renal failure and syndrome end-stage disease permanently increases. New dietary regimens are necessary to improve status severe kidney diseases. Nutrition plays an essential role in contemporary approach management failure. Low-protein diet delays progression The meta-analysis effect protein restriction on course diabetic non-diabetic diseases outlines importance adequate correction uremic absence side effects this nutritional regimen. development...