A5088269891- Vitamin D Research Studies
- Bone health and treatments
- Hemoglobinopathies and Related Disorders
- Multiple Myeloma Research and Treatments
- Phytochemicals and Antioxidant Activities
- Iron Metabolism and Disorders
- Pregnancy and Medication Impact
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Peptidase Inhibition and Analysis
- Vitamin K Research Studies
- Phytochemistry and Biological Activities
- Adenosine and Purinergic Signaling
- Psoriasis: Treatment and Pathogenesis
- Salivary Gland Disorders and Functions
- Pediatric health and respiratory diseases
- Fermentation and Sensory Analysis
- Human Health and Disease
- Therapeutic Uses of Natural Elements
- HIV-related health complications and treatments
- Alcohol Consumption and Health Effects
- Gout, Hyperuricemia, Uric Acid
- Medicinal plant effects and applications
- IL-33, ST2, and ILC Pathways
- Chemotherapy-induced cardiotoxicity and mitigation
- Hormonal and reproductive studies
Medical University of Varna
2015-2024
University Hospital St. Marina
2016-2020
Abstract The water phase antioxidant activity of extracts from 23 Bulgarian medicinal plants was studied in relation to their polyphenol content comparison with mate, black tea, honeybush and rooibos foreign species. Antioxidant measured by the ABTS (2,2′‐azinobis(3‐ethylbenzothiazoline‐6‐sulfonic acid)) cation radical decolorization assay, total assayed according Folin‐Ciocalteu method. Five plant exhibited higher than that which is 21.7% all herbs included this study. These were Alchemilla...
Endothelial dysfunction is one of the major factors in pathogenesis metabolic syndrome (MetS), and its molecular mechanisms are not completely understood. The present study aimed to examine connection between nuclear factor2-related factor2 (Nrf2), factor kappa-light-chain-enhancer activated B cells (NF-κB), heme oxygenase 1 (HO-1), plasma asymmetric dimethylarginine (ADMA) malondialdehyde (MDA) people with MetS. Participants were as follows: MetS (n = 30) without (Control) 14). Expression...
The present pilot study aimed to determine vitamin D status in Bulgarian patients with chronic HCV infection respect the severity of liver disease and response interferon-ribavirin therapy.The encompassed 296 patients: 161 males (54.4%) aged 42.08 ± 14.87 years, 135 females (45.6%) 45.72 14.34 86.5% them infected genotype 1. Total 25-hydroxyvitamin-D (25OHD) was determined by liquid chromatography/tandem-mass spectrometric detection.The median 25OHD level studied cohort 50.40 nmol/L (range:...
Dickkopf-1 (DKK-1) and sclerostin are essential Wnt/β-catenin pathway inhibitors, playing an important role in multiple myeloma bone disease (MBD). We aimed to examine the serum DKK-1 variations newly diagnosed (NDMM) patients at diagnosis course of therapy, including autologous stem cell transplantation (ASCT). This study included 41 NDMM-patients 33 controls. MBD was assessed by whole-body low-dose computed tomography. were assayed commercial ELISA kits. At diagnosis, revealed...
BACKGROUND Inflammatory bowel disease (IBD) is a multifactorial immunologically mediated disorder characterized by repeated cycles of exacerbations and remissions. Diagnosis monitoring ulcerative colitis (UC) Crohn's (CD) as common types IBD require the usage unpleasant invasive methods such colonoscopy cross-sectional imaging. Development non-invasive biomarker panel including different inflammatory parameters for evaluation various aspects gut inflammation course priority task. In addition...
Background: It is considered that obesity and metabolic syndrome are accompanied with vitamin D deficiency. We aimed to examine the interrelations between status biomarkers for in Bulgarian pre-pubertal children.Methods: The study enrolled 51 children (29 boys, 22 girls) examined serum 25-xydroxyvitamin D, routine parameters syndrome. Obesity was evaluated by body mass index waist circumference.Results: More than half (57.1%) of studied were deficient, prevalent girls boys (65.0% vs. 51.7%...
Circulating uncarboxylated matrix Gla protein (ucMGP) is possibly related to coronary arterial calcification (CAC) in cardiovascular disease (CVD) patients.We aimed evaluate the relationships between circulating ucMGP, CVD pathology and CAC its interplay with risk factors.ucMGP was measured 99 CVD-patients. score determined by multislice computed tomography. (ucOC) carboxylated osteocalcin (cOC) were assayed ELISA kits. Vitamin-K status evaluated ucOC/cOC ratio.A tendency for decreased ucMGP...
SUMMARY Purpose: To determine and compare the vitamin D status of different groups CKD patients on hemodialysis, peritoneal dialysis, or no renal replacement therapy to evaluate effect therapy. Patients Methods: This pilot study enrolled 40 consecutive (21 men, 19 women) divided into three groups: 15 in 1,2,3,4 stage disease without (RRT); 10CKD hemodialysis (HD) dialysis (PD), ten which were Vitamin was determined by serum 25xydroxyvitamin (25OHD).
Introduction : Vitamin D may act as immune modulator in psoriasis and be related with disease characteristics. Our study aimed to evaluate the vitamin status patients admitted for diagnostics or exacerbation of psoriasis. Material methods 92 (50 male, 42 female, mean age 55 years) were included analysis. Disease severity was assessed by Psoriasis Area Severity Index (PASI). Type classified according at presentation early (up 40 late (above years). Serum levels 25-hydroxyvitamin D, 25(OH)D,...
Saliva is a noninvasive and accessible biofluid that permits early detection of oral systemic diseases. Changes in saliva reflect the alterations blood thus making suitable diagnostic tool. The use has many advantages, including simple non-invasive sampling easy, low-cost storage. Today salivary diagnostics promising tool for processes clinical monitoring. used to detect illicit drugs, alcohol, measure hormone levels, diagnosis wide range diseases such as cardiovascular, infectious, renal,...
The hallmark of multiple myeloma is related bone disease. Interactions between plasma cells (MPCs), stromal cells, and the marrow (BM) microenvironment play a critical role in pathogenesis MBD. Bone remodeling severely dysregulated with prevalence osteoclast activity. We aimed to assess circulating levels sRANKL, periostin, osteopontin as activators NDMM patients at diagnosis course treatment, correlations clinical laboratory data, evaluate their potential additional biomarkers for...
Vitamin D plays a crucual role during pregnancy. Its active form calcitriol is of utmost importance for placental physiology, the synthesis estradiol, progesterone, human chorionic gonadotropin, embryogenesis, and normal progression Taking in mind beneficial on pregnancy, it could be supposed that its inadequacy may lead to deleterious consequences mother fetus. Several studies reveal correlation between low vitamin levels pregnancy development unfavorable as well fetus: risk preterm birth,...
There is an exciting research expansion on the novel roles of vitamin K in last decades. Subclinical deficiency believed to be widely spread, possibly contributing age-related diseases. The present review focused effects skeleton and blood vessels, where it could potentially useful prevention treatment osteoporosis vascular calcification, both having a significant health impact society. types (K1 K2), nature sources are reviewed as well mechanisms action underlying their effects....
Introduction : Psoriasis is a chronic immune-mediated inflammatory disease. Human cathelicidin (hCAP18/LL37) has been elucidated recently as modulator of inflammation in the affected skin. Vitamin D may induce expression this antimicrobial peptide. Our trial aimed to study circulating level hCAP18/LL-37 and explore its relationship with severity psoriasis. Material Methods 79 patients moderate severe psoriasis (PASI >10) were included retrospective analysis. Stored serum samples used for...
Abstract To analyze the effects of conventional polychemotherapy acute myeloblastic leukemia (AML) patients on prooxidants/antioxidants balance in plasma total antioxidant status (TAS) and a single — uric acid (UA) were measured. Lipid peroxidation was assessed by malonedialdehyde (MDA) content. Total serum iron monitored as potential source nontransferrin-bound with role initiation oxidative burst. A group phase AML (group A) complete remission B) studied. strong correlation between UA...
Purpose: To assess the role of asymptomatic hyperuricemia for presence and severity coronary arterial calcium (CAC) in adults with different cardiovascular (CV) pathology its association conventional CV risk factors. Material/Methods: Adults (n=81) both genders were divided into controls: moderate- to high without known CVD; AF-group: CVD-patients paroxysmal or persistent atrial fibrillation sinus rhythm, HF–group: heart failure subjects preserved ejection fraction. A structured interview...
Introduction: The pathogenesis of psoriasis is complex. Genetic factors have a basic role, followed by immunological disturbances, which been found to provoke chronic inflammatory process affecting the skin and joints. study aimed establish analyze relationship between manifestations vitamin D status in patients with psoriasis. Patients methods: We investigated 113 moderate or severe psoriasis, divided two groups for analysis: presence without psoriatic arthritis (n=73) (n=40). Clinical data...