A5001569331- Vitamin K Research Studies
- Vitamin D Research Studies
- Phytochemicals and Antioxidant Activities
- Vitamin C and Antioxidants Research
- Antioxidant Activity and Oxidative Stress
- Natural Antidiabetic Agents Studies
- Bone health and treatments
- Prostate Cancer Treatment and Research
- Aquaculture Nutrition and Growth
- Phytochemistry and Biological Activities
- Innovative Teaching Methods
- Lipoproteins and Cardiovascular Health
- Genomics, phytochemicals, and oxidative stress
- Parathyroid Disorders and Treatments
- Pregnancy and Medication Impact
- Pharmacological Effects and Toxicity Studies
- Biochemical effects in animals
- Hormonal and reproductive studies
- Multiple Myeloma Research and Treatments
- Pancreatitis Pathology and Treatment
- Helicobacter pylori-related gastroenterology studies
- Drug-Induced Hepatotoxicity and Protection
- Diabetes Treatment and Management
- Health and Medical Research Impacts
- Herbal Medicine Research Studies
Medical University of Varna
2016-2025
Medical University of Sofia
2018
Abstract The water phase antioxidant activity of extracts from 23 Bulgarian medicinal plants was studied in relation to their polyphenol content comparison with mate, black tea, honeybush and rooibos foreign species. Antioxidant measured by the ABTS (2,2′‐azinobis(3‐ethylbenzothiazoline‐6‐sulfonic acid)) cation radical decolorization assay, total assayed according Folin‐Ciocalteu method. Five plant exhibited higher than that which is 21.7% all herbs included this study. These were Alchemilla...
Epidemiological studies reveal associations between obesity/metabolic syndrome and mood disorders. We assessed behavioural changes in rats fed diets enriched fat fructose different proportions correlated the observed alterations with biochemical induced by diets. Three groups of were used as follows: control (C) animals regular rat chow, high-fat diet (HF) high-fructose (HFHF). HF HFHF also given a 10% solution drinking water. Behavioural parameters determined. Anxiety was measured...
Metabolic syndrome (MS) is a disorder comprising central obesity, dyslipidemia, raised blood pressure, insulin resistance.The aim of the present study was to develop cheap, easy and reproducible rat model MS. 36 male Wistar rats were divided in 3 groups: control group (C) receiving regular chow diet, high-fat (HF) lard enriched high-fructose (HFHF) fructose chow. HF HFHF groups had also 10% their drinking water. The duration 8 weeks. Body weights measured weekly. At end tolerance test (ITT)...
One mechanism to regulate pathological vascular calcification (VC) is its active inhibition. Loss or inactivation of endogenic inhibitors a major inductor VC. Such are proteins rich in gamma-glutamyl residues (Gla-proteins), whose function strongly depends on vitamin K. The current narrative review focused discussing the role extrahepatic K-dependent Gla-proteins (osteocalcin, OC; matrix Gla-protein, MGP; Gla-rich protein, GRP) cardio-vascular pathology. possess several functionally forms...
Aronia melanocarpa L. (black chokeberry), belonging to the Rosaceae family, contains high amounts of polyphenolics and therefore exhibits one highest antioxidant anti-inflammatory activities among berry fruits. Chokeberries are used in food industry for juice, nectar, wine production as colorants. We aimed compare phytochemical composition three chokeberry juices commercially available local market sources beneficial phytochemicals. Using GC-MS LC-MS/MS, we performed identification...
Sambucus ebulus L. (SE) fruits are used for their immunostimulation, hematopoietic and antiviral potential. Recently, we focused on analyzing the mechanism underlying SE fruit aqueous extract's (FAE) immunomodulation anti-inflammatory activities, with attention to its endoplasmic reticulum (ER) stress-reducing J774A.1 macrophages were treated FAE alone or in conditions of lipopolysaccharides (LPS) stimulation. Using GC-MS LC-MS/MS, phytochemical composition was analyzed. To measure...
Sambucus ebulus (SE) fruits are used for immune stimulation and amelioration of gastrointestinal inflammatory conditions. Currently, there is no scientific evidence their effects on various aspects the response mechanisms in humans. The purpose this study was to evaluate immunomodulatory potential SE fruit infusion intake healthy Anthocyanin content determined with UPLC-ESI-MS/MS. Fifty-three volunteers enrolled a 4-week intervention. Blood count, serum total protein, Interleukin 1 beta...
The present pilot study aimed to determine vitamin D status in Bulgarian patients with chronic HCV infection respect the severity of liver disease and response interferon-ribavirin therapy.The encompassed 296 patients: 161 males (54.4%) aged 42.08 ± 14.87 years, 135 females (45.6%) 45.72 14.34 86.5% them infected genotype 1. Total 25-hydroxyvitamin-D (25OHD) was determined by liquid chromatography/tandem-mass spectrometric detection.The median 25OHD level studied cohort 50.40 nmol/L (range:...
Retinol, alpha-tocopherol and fatty acid content in Bulgarian Black Sea fish species.The aim of the present study was to measure evaluate total lipids, profile, retinol edible tissue four commercially important species from sea: Sprat (Sprattus sprattus), Round Goby (Neogobius rattan), Horse Mackerel (Trahurus medditeraneus ponticus) Shad (Alosa pontica).Fat soluble vitamins were analyzed simultaneously using an HPLC system.The highest established (142.3 6 4.4 mg/100g) alphatocopherol found...
The antiproliferative effect of the active form vitamin D on cancer cells and its ability to induce cell differentiation suppression tumor-induced angiogenesis in last decade has provoked enormous research for elucidation role prevention different types slowing down malignancy progression. aim present pilot study was determine circulating 25-hydroxy (25OHD) levels Bulgarian prostate (PCa) patients investigate their relationship with various determinants associated severity progression...
Abstract The present cross‐sectional clinical study aimed to examine the connection between statin exposure, coronary artery calcification (CAC), and vitamin K‐dependent proteins (VKDPs) in patients with cardiovascular (CV) conditions. Two groups of were studied: established CV disease (CVD) healthy at moderate risk for CVD (a control group). also split into users non‐users. following VKDPs measured plasma: uncarboxylated Matrix Gla‐protein (ucMGP), undercarboxylated (ucOC), carboxylated...
Dickkopf-1 (DKK-1) and sclerostin are essential Wnt/β-catenin pathway inhibitors, playing an important role in multiple myeloma bone disease (MBD). We aimed to examine the serum DKK-1 variations newly diagnosed (NDMM) patients at diagnosis course of therapy, including autologous stem cell transplantation (ASCT). This study included 41 NDMM-patients 33 controls. MBD was assessed by whole-body low-dose computed tomography. were assayed commercial ELISA kits. At diagnosis, revealed...
1 There is an increasing body of evidence supporting the hypothesis that antioxidants are able to reduce gastric mucosal damage induced by stressors different origin. The aim present study was investigate influence dl-alpha-tocopherol acetate (TA) on indomethacin-induced injury in rats and a possible role for anti-oxidative mechanism response. 2 TA (25, 50 100 mg kg(-1)) applied intraperitoneally as pretreatment h before subcutaneous administration indomethacin (30 kg(-1)). 3 reduced area...
BACKGROUND Inflammatory bowel disease (IBD) is a multifactorial immunologically mediated disorder characterized by repeated cycles of exacerbations and remissions. Diagnosis monitoring ulcerative colitis (UC) Crohn's (CD) as common types IBD require the usage unpleasant invasive methods such colonoscopy cross-sectional imaging. Development non-invasive biomarker panel including different inflammatory parameters for evaluation various aspects gut inflammation course priority task. In addition...