Epidemiological studies reveal associations between obesity/metabolic syndrome and mood disorders. We assessed behavioural changes in rats fed diets enriched fat fructose different proportions correlated the observed alterations with biochemical induced by diets. Three groups of were used as follows: control (C) animals regular rat chow, high-fat diet (HF) high-fructose (HFHF). HF HFHF also given a 10% solution drinking water. Behavioural parameters determined. Anxiety was measured...

Metabolic syndrome (MS) is a disorder comprising central obesity, dyslipidemia, raised blood pressure, insulin resistance.The aim of the present study was to develop cheap, easy and reproducible rat model MS. 36 male Wistar rats were divided in 3 groups: control group (C) receiving regular chow diet, high-fat (HF) lard enriched high-fructose (HFHF) fructose chow. HF HFHF groups had also 10% their drinking water. The duration 8 weeks. Body weights measured weekly. At end tolerance test (ITT)...

Abstract Background: The metabolic syndrome is a socially important disorder of energy utilization and storage, recognized as factor predisposing to the development depression, anxiety cognitive impairment in humans. Aim: In present study we examined effects vitamin K2 on behavior rats with looked for relationships blood sugar. Materials methods: Male Wistar were divided four groups: control group regular rat chow, (MS) fed high-fat high-fructose diet, treated MS K2. Vitamin was given by...

Statins are cholesterol-lowering drugs widely used for cardiovascular prevention. Although safe when alone, in combination with other the likelihood of adverse drug reactions increases significantly. The exposure Bulgarian population to coprescriptions leading potential statin-drug interactions is currently unknown.The aim this study was investigate incidence involving statins and compare outpatients inpatients interactions.A cardiology clinic teaching University hospital Varna,...

The main biologically active constituents of Aronia melanocarpa fruit juice (AMFJ) are polyphenolics, amongst them flavonoids, mainly anthocyanins. aim the present study was to investigate effects AMFJ (5 and 10 mL/kg) on anxiety using social interaction test, locomotor activity in open field test working memory object recognition rats. showed an anxiolytic-like effect which demonstrated by a dose-dependent increase time contacts between partners. both doses were comparable diazepam (1...

Abstract The present cross‐sectional clinical study aimed to examine the connection between statin exposure, coronary artery calcification (CAC), and vitamin K‐dependent proteins (VKDPs) in patients with cardiovascular (CV) conditions. Two groups of were studied: established CV disease (CVD) healthy at moderate risk for CVD (a control group). also split into users non‐users. following VKDPs measured plasma: uncarboxylated Matrix Gla‐protein (ucMGP), undercarboxylated (ucOC), carboxylated...

Introduction: Overweight and obesity are disorders of energy metabolism, associated with oxidative stress chronic low-grade inflammation. Aronia melanocarpa fruits rich in polyphenolic compounds antioxidant properties. The fruit juice exhibits lipid-lowering, antihyperglycemic, hepatoprotective activities experimental settings. Aim: study aimed to examine the effects on stress, homeostasis, liver function overweight healthy-weight volunteers. Materials Methods: included 11 individuals....

Recent advances have shed light on the relationship between smooth muscle cell (SMC) phenotypic modulation, resolution of inflammation and atherosclerotic plaque stability. The thick fibrous cap covering lipid core plaques is composed bundles SMC collagen fibers few macrophages lymphocytes, all which make resistant to rupture. thin contains many less fibers, may weaken cap, leaving vulnerable In present Dance Round, we, at a pharmacotherapeutic level, address possibility how control over...

Hepatic injury is a feature of the metabolic syndrome (MS) [1].Fruits Aronia melanocarpa are distinguished by their high polyphenol content.Aronia fruit juice (AMFJ) has been studied for its potential hepatoprotective effects in animal models liver damage [2].The goal this study was to elucidate AMFJ on an experimental model high-fat, high-fructose (HFHF) diet-induced MS.Fifty rats were allocated five groups (control, MS, MS+AMFJ2.5,MS+AMFJ5 and MS+AMFJ10).In course 10-weeks, control group...

Abstract This study evaluated the effects of Aronia melanocarpa fruit juice (AMFJ) on liver in a model high-fat, high-fructose (HFHF) diet-induced metabolic syndrome (MS). Fifty rats were allocated to five groups – Control, MS, MS+AMFJ 2.5 , 5 and 10 . The control group was fed standard diet, while other provided HFHF diet. During MS induction, daily oral treatment performed. Control received 10.0 mL kg −1 distilled water, three AMFJ at doses 2.5, 5.0, respectively. After weeks, samples...

Abstract Introduction Metabolic syndrome (MS) is often associated with anxiety and depression. Chaenomeles japonica (Thunb.) Lindl, also known as maulei or Japanese quince, a medicinal plant long history of use forits health-promoting properties. Aim The aim this study was to investigate the effects quince fruit juice (JQFJ) administration on locomotor activity, depressive behavior in rats diet-induced MS. Materials methods Forty adult male Wistar were divided into 4 groups: MS, MS+JQFJ2.5,...

PURPOSE: This study evaluated the effects of polyphenol-rich Aronia melanocarpa fruit juice (AMFJ) on behavior rats with metabolic syndrome (MS) induced by high-fat high-fructose diet. METHODS: Fifty were allocated into 5 groups (10 per group): control, MS, MS + AMFJ2.5, AMFJ5 and AMFJ10. During induction in course 10 weeks, last three treated AMFJ at doses 2,5 ml/kg, ml/kg ml kg, respectively. The open field test was used to examine locomotion, social interaction evaluate anxiety,...

Atherosclerosis and its complications, erosion rupture of the plaque fibrous cap, lead to myocardial infarction stroke, main causes mortality worldwide. In this setting, arterial smooth muscle cells (SMC) innermost media undergo phenotypic changes, a switch towards secretory phenotype engaged in matrix proteins production. nature, is protective action that forms new layer, cap covering thrombogenic lipid core. The risk inversely correlated with presence state SMC collagen fibrils within cap....

There is an exciting research expansion on the novel roles of vitamin K in last decades. Subclinical deficiency believed to be widely spread, possibly contributing age-related diseases. The present review focused effects skeleton and blood vessels, where it could potentially useful prevention treatment osteoporosis vascular calcification, both having a significant health impact society. types (K1 K2), nature sources are reviewed as well mechanisms action underlying their effects....

Isoteoline is a compound of aporphine structure derived from the alkaloid glaucine. Previous studies with isoteoline have shown antagonistic activity at 5-HT(2C) serotonergic receptors. We investigated whether interacts 5-HT(1B) An isolation-induced social behavioural deficit test in mice was used as model stimulation these The behaviour isolated this experimental procedure reported to be sensitive 5-HT(1B)-receptor stimulation, since agonists receptors are capable reversing it. In our...

Vitamin K (VK) is a co-factor in the post-translational gamma glutamic carboxylation of Gla-proteins. VK-dependent coagulation factors are carboxylated liver by VK1. Osteocalcin and Matrix-Gla protein (MGP) extrahepatic tissues VK2. A model VK deficiency would be suitable for studying Gla-proteins provided that severe bleeding prevented.The aim this work was to adapt an established protocol vascular calcification warfarin-induced inactivation MGP as inhibitor, attempt create broader state...