A5043799018- Systemic Lupus Erythematosus Research
- Neonatal Respiratory Health Research
- Monoclonal and Polyclonal Antibodies Research
- Congenital Diaphragmatic Hernia Studies
- Complement system in diseases
- T-cell and B-cell Immunology
- Inhalation and Respiratory Drug Delivery
- Renal Diseases and Glomerulopathies
- Infant Nutrition and Health
- Blood groups and transfusion
- Lipid Membrane Structure and Behavior
- Aerosol Filtration and Electrostatic Precipitation
- Gastroesophageal reflux and treatments
- Biochemical and Structural Characterization
- Tracheal and airway disorders
- Toxin Mechanisms and Immunotoxins
- Antimicrobial Peptides and Activities
- Diabetes and associated disorders
- Diet, Metabolism, and Disease
- Neuroscience of respiration and sleep
- Venomous Animal Envenomation and Studies
- Antimicrobial agents and applications
Sofia University "St. Kliment Ohridski"
2010-2021
Faculty (United Kingdom)
2015
Many complement structures and a number of additional factors, i.e. autoantibodies, receptors, hormones cytokines, are implicated in the complex pathogenesis systemic lupus erythematosus. Genetic defects as well functional deficiency due to antibodies against its components lead different pathological conditions, usually clinically presented. Among them hypocomplementemic urticarial vasculitis, types glomerulonephritis dense deposit disease, IgA nephropathy, atypical haemolytic uremic...
We analyzed the structural features of C1q that underlie its autoantigenicity by means a model system using an amphiphilic polyzwitterion (PZ).
We addressed the issue of C1q autoantigenicity by studying structural features autoepitopes recognized polyclonal anti-C1q antibodies present in Lupus Nephritis (LN) sera. used six fractions as antigens and selected anti-idiotypic scFv from phage library “Griffin.1”. The monoclonal A1 was most potent inhibitor recognition its fragments ghA, ghB ghC, comprising globular domain gC1q, lupus autoantibodies. It sequenced silico folded molecular dynamics into a 3D structure. generated model...
Purpose: Alveolar surfactant (AS) components, including the specific proteins (SPs) SP-A, SP-B, SP-C, and SP-D, provides stability during dynamic process of inhalation/exhalation. In prematurely born children different respiratory pathologies due to components deficiency, like Neonatal Respiratory Distress Syndrome, can be observed. Administration corticosteroids pregnant women at risk preterm birth is an established intervention in clinical practice. this study, we analyzed gastric...
Introduction : Lupus nephritis (LN) is a serious complication of the systemic lupus erythematosus (SLE). Anti-C1q antibodies correlate with occurrence and high clinical activity LN, especially proliferative LN. The first reported anti-C1q recognized autoepitopes within collagen-like region (CLR) C1q. Recently we have found autoantibodies against globular C1q domain (gC1q antibodies) in LN patients. aim present study was to evaluate potential pathological consequences presence anti-gC1q...
SPECIFIC SURFACTANT PROTEINS AS CLINICAL MARKERS FOR LUNG MATURITY IN RISK NEWBORNS
One of the main causes for higher mortality among risk newborn children (including preterm infants) is neonatal respiratory distress syndrome (NRDS), which develops as a result primary deficiency or secondary inactivation alveolar surfactant (AS). Therefore, fast and early diagnostics newborns lung maturity crucial their prompt therapy.Gastric aspirates (GA) were collected from 77 infants divided into three groups: control 38 healthy full-term infants; 16 prematurely with NRDS, 23 born after...