A5025934452- Plant Genetic and Mutation Studies
- Inflammatory Bowel Disease
- DNA Repair Mechanisms
- Chromosomal and Genetic Variations
- Gastric Cancer Management and Outcomes
- Wheat and Barley Genetics and Pathology
- Digestive system and related health
- Photosynthetic Processes and Mechanisms
- Helicobacter pylori-related gastroenterology studies
- Liver Disease Diagnosis and Treatment
- Plant tissue culture and regeneration
- Microscopic Colitis
- Fungal and yeast genetics research
- Infant Nutrition and Health
- Colorectal Cancer Screening and Detection
- Liver Disease and Transplantation
- Hepatitis C virus research
- Pharmacological Effects of Natural Compounds
- Genetic Mapping and Diversity in Plants and Animals
- Plant Disease Resistance and Genetics
- COVID-19 Clinical Research Studies
- Bioenergy crop production and management
- Steroid Chemistry and Biochemistry
- Autoimmune and Inflammatory Disorders
- Mycobacterium research and diagnosis
Gomel State Medical University
2006-2024
St Petersburg University
2002-2021
Vavilov Institute of General Genetics
2006-2019
Gomel Engineering Institute
2017
North-Eastern Federal University
2015
Russian Academy of Sciences
2010
Relevance . The development and production of own vaccine contributes to the growth professional competencies scientific community, improvement modernization country's industrial production. Aims To evaluate immunogenicity parameters whole-virion against SARS-CoV-2 in a phase I, II clinical trial (up day 180). Materials & Methods study included I/II trial. In Phase sequential allocation subjects (1:1) by open-label method into two groups with single administration at dose 1 2 was...
Summary Background High concentration mesalazine formulations are more convenient than conventional low for the treatment of ulcerative colitis ( UC ). Aim To compare efficacy and safety 1600 mg 400 tablet formulations. Methods Patients with mild‐to‐moderate active (Mayo Clinic Score >5; N=817) were randomised to 3.2 g oral mesalazine, administered as two tablets once, or four twice daily. We hypothesised that was non‐inferior (within a 10% margin) induction clinical endoscopic remission...
ABSTRACT The nuclear dispositions of subtelomeric and pericentromeric domains in pollen mother cells (PMCs) were tracked during meiosis wildtype two asynaptic mutants rye (Secale cereale L.) by means fluorescence situ hybridization (FISH). Homozygotes for sy1 sy9 non-allelic mutations form axial elements leptotene male meiosis, but fail to synaptonemal complexes. Consequently, recombination is severely impaired, high univalency observed at metaphase I. Simultaneous FISH with pSc200 tandem...
During prophase I a meiosis-specific proteinaceous tripartite structure, the synaptonemal complex (SC), forms scaffold to connect homologous chromosomes along their lengths. This process, called synapsis, is required in most organisms promote recombination between homologs facilitating genetic variability and correct chromosome segregations during anaphase I. Recent studies various ranging from yeast mammals identified several proteins involved SC formation. However, process of disassembly...
Abstract Assembly of two orthologous proteins associated with meiotic chromosome axes in Arabidopsis thaliana (Asy1 and Zyp1) was studied immunologically at prophase meiosis wild-type rye (Secale cereale) its synaptic mutant sy10, using antibodies derived from A. thaliana. The temporal spatial expression the were similar rye, but one notable difference. Unlike thaliana, which foci transverse filament protein Zyp1 appear to linearize commensurately synapsis, linear tracts Asy1 form...
Relevance. According to the World Health Organization (WHO), it is not yet possible effectively stop spread of new strains coronavirus [1]. At same time, most experts and analysts in field medicine publicly admit that at moment vaccination powerful weapon fight against COVID-19 [2–6]. While vaccination, like entire health care system, has now become an element politics economics, creation proprietary vaccine each country national security [7]. Aims. To evaluate safety inactivated booster...
Spontaneous meiotic mutations of winter rye <i>Secale cereale</i> L. (2n = 14) were revealed in inbred F<sub>2</sub> progenies, which obtained by self-pollination F<sub>1</sub> hybrids resulting from crosses individual plants cultivar Vyatka or weedy with self-fertile lines. The cause partial complete sterility, and are maintained heterozygote condition. Six types distinguished as the result cytological analysis meiosis genetic analysis. (1) Plants...
We describe how we are furthering our understanding of meiosis in rye (<i>Secale cereale</i> L.) using a combination cytogenetic and molecular biological approaches. Fluorescent situ hybridisation, electron microscopy synaptonemal complexes, sequencing meiosis-specific genes, the immunolocalisation recombinogenic proteins being combined to build up phenotypic “identikits” wild type, asynaptic mutants <i>sy1</i> <i>sy9</i>, desynaptic mutant...
Much of our understanding the genetic control meiosis has come from recent studies model organisms, which have given us valuable insights into processes such as recombination and synapsis chromosomes. The challenge now is to determine what extent these models are representative other groups generalisations can be made how works. Through a comparative proteomic approach with Arabidopsis thaliana, this study describes spatial temporal expression key structural recombinogenic proteins cereal...
The article provides information about the history and methods of development Peterhof rye genetic collection, founded by V.S. Fedorov, Associate Professor Leningrad University. Isolation self-compatible mutants, their crosses with self-incompatible plants, subsequent self-pollination hybrids allowed to reveal allele diversity in heterogeneous heterozygous varieties. In course collection assembly study inheritance qualitative quantitative morphological traits, control self-compatibility,...
Alcohol is a toxic substance that associated with spectrum of liver damage, including simple steatosis or fatty- degeneration liver, alcoholic hepatitis, fibrosis, and cirrhosis. Alcoholic disease (ALD) the general term used for this alcohol-related damage. Excessive harmful alcohol use among top five risk factors death disability worldwide, causing 2.5 million deaths 69.4 annual disability-adjusted life years. The diagnosis ABP can usually be made on basis anamnesis, clinical laboratory...
<h3>Introduction</h3> High concentration 5-ASA formulations have potential to improve patient adherence and increase therapeutic efficacy in ulcerative colitis (UC). We conducted a multicenter, double-blind, randomised placebo controlled trial assess the safety of an 800 mg Octasa<sup>®</sup> tablet for induction remission. <h3>Methods</h3> The was at 26 centres Belarus, India, Turkey Ukraine from November 2009 May 2011. Eligible patients had active UC with minimum disease extent 15 cm anal...
Objective . To evaluate the prevalence of PNPLA3 gene variants in patients with liver cirrhosis (CKD) outcome alcoholic disease (ALD), and influence mutation on course case Belarusian population. Materials methods A total 260 subjects Caucasian origin were included study divided into three groups: group I - ALD CKD features (n=91), II without (n=51), III healthy volunteers (n=118). Results The GG genotype was prevalent persons compared to (χ2=10.64; p=0.001 χ2=4.87; p=0.03, respectively)....