A5029995402- Helicobacter pylori-related gastroenterology studies
- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- SARS-CoV-2 and COVID-19 Research
- Cervical Cancer and HPV Research
- Vaccine Coverage and Hesitancy
- Galectins and Cancer Biology
- Systemic Lupus Erythematosus Research
- Hepatitis B Virus Studies
- Veterinary medicine and infectious diseases
- COVID-19 Clinical Research Studies
- Neurological Disorders and Treatments
- Reproductive System and Pregnancy
- Pediatric health and respiratory diseases
- Liver physiology and pathology
- Animal Virus Infections Studies
- Gut microbiota and health
- Medical and Biological Sciences
- Liver Disease and Transplantation
- Nutrition, Genetics, and Disease
- Eosinophilic Esophagitis
- Microbial Metabolites in Food Biotechnology
- Gastroesophageal reflux and treatments
- Endometriosis Research and Treatment
- Gastric Cancer Management and Outcomes
Gomel State Medical University
2016-2025
Belarusian State Medical University
2017
9th City Clinical Hospital
2017
Relevance . The development and production of own vaccine contributes to the growth professional competencies scientific community, improvement modernization country's industrial production. Aims To evaluate immunogenicity parameters whole-virion against SARS-CoV-2 in a phase I, II clinical trial (up day 180). Materials & Methods study included I/II trial. In Phase sequential allocation subjects (1:1) by open-label method into two groups with single administration at dose 1 2 was...
Objective . To evaluate dynamic changes in the gastric microbiota against background of Helicobacter pylori eradication therapy a patient with gastritis using method high-throughput sequencing based on analysis variable regions 16s rRNA gene. Materials and methods The (male, 57 years old) chronic associated (H. pylori) moderately severe active antrum body stomach without atrophy metaplasia. There is no primary resistance H. to clarithromycin according polymerase chain reaction results. Next...
Objective . To assess the efficacy of immunogenicity Soberana Plus (FINLAY-FR-1A) vaccine in adults previously vaccinated against COVID-19. Materials and methods A total 98 participants participated study. The was studied by measuring IgG concentration to SARS-CoV-2 enzyme-linked immunosorbent assay (ELISA) at 4 study sites: day 0, 42 days, 90 days 180 after administration. Results Participants were divided into groups based on their primary immunization: 1) Sputnik V (Gam-COVID-Vac) /...
The change in the mechanical properties of red blood cell membrane was analyzed patients with ongoing or past COVID-19 infection compared to control during observation period from 2021 2023. Significant differences friction force (p<0.001) and roughness (p<0.0032) were found acute/past coronavirus control. It noted that maximum changes are observed highest incidence COVID-19. (Fl) (Rq) can be used assess severity infection, future, other diseases.
The urobiome is being actively studied, diagnostics are improved and new markers of inflammatory diseases the urinary tract searched for, despite fact that most microorganisms unidentified their functions remain not fully understood. aim study was to composition microbiota (urobiota) in patients with liver cirrhosis, depending on presence infection. Material methods. A prospective cohort single-center conducted 48 cirrhosis (30 men, 18 women), who, addition standard studies, underwent...
Objective. To determine the composition of microbiota ascitic fluid in patients with liver cirrhosis and compare it intestinal urobiota. Materials methods . A cross-sectional single-center study was conducted for 5 hospitalized decompensated ascites who, along standard research methods, underwent metagenomic sequencing fluid, urine feces. High-throughput performed using a MiSeq genetic analyzer (Illumina, USA) protocol based on analysis variable regions 16s rRNA gene. The assignment...
Objective. To establish the composition of microbiome and select target taxa upper respiratory tract biomaterial in order to apply results model diagnosis Congenital pneumonia (ICD – 10 P23), based on a microbiome-associated approach providing medical care premature newborns. Materials methods . The study group consisted 154 sampling was carried out first 5-15 minutes life with sterile probe swab. microbiota newborns determined by new generation sequencing method. Statistical data processing...
The aim of this study was to assess the gastric histopathology and serum gastrin-17 pepsinogens profiles in patients with duodenal ulcer before after Helicobacter pylori eradication a population very high prevalence H. pylori. At same time we assessed role density on these variables.Eighty Caucasian pylori-associated treatment 1 year randomized were studied. Among unsuccessful two groups distinguished according data obtained treatment: group negative rapid urease test decreased bacterial...
Relevance. According to the World Health Organization (WHO), it is not yet possible effectively stop spread of new strains coronavirus [1]. At same time, most experts and analysts in field medicine publicly admit that at moment vaccination powerful weapon fight against COVID-19 [2–6]. While vaccination, like entire health care system, has now become an element politics economics, creation proprietary vaccine each country national security [7]. Aims. To evaluate safety inactivated booster...
There are few comparative studies on efficiency of broad range COVID19 vaccination strategy. This pilot aims to describe the effect mixed adoption and subsequent total immunity, Conducted in Republic Belarus, this clinical study shows varying immunogenic responses Sputnik V (Gam-COVID-Vac), Russian Federation (RF) Sinopharm (BBIBP-CorV), People's China (PRC) vaccines.To compare immunogenicity reactogenicity (Gam-COVID-Vac) (BBIBP-CorV) vaccines vaccinated individuals.Materials MethodsA 60...
The present paper represents examination results of 210 women with dysplasia and cervical carcinoma. rate various papilloma viruses depending on severity pathology is shown. For the diagnostics, molecular-biological method PCR use multi-primer technology was applied. analyses incidence human high average cancerogenic risk in affected epithelium light degree, squamous cell
Abstract Introduction Lack of comparative studies on efficiency a broad range COVID19 vaccines leads to lower levels adoption and subsequent total immunity in several regions, including Republic Belarus. This clinical study captures transparently demonstrates varying immunogenic responses Sputnik V Sinopharm vaccines. Aim this was compare the immunogenicity reactogenicity (Gam-COVID-Vac), RF (BBIBP-CorV), PRC vaccinated individuals. Materials Methods A 60 adults participated study. The...
The COVID-19 infection pandemic is characterized by high morbidity, unclear prognosis of complications and a decrease in the quality life patients. article presents results prospective single-center cohort study 134 patients who suffered from mild moderate forms. 99 reported presence any disorders at time survey, 35 absence problems. 53,7% respondents were concerned about pain and/or discomfort, 41,8% experienced feeling anxiety depression mobility disorders. median for EQ-VAS with no...
Objective: to study the level of interleukin-6 in blood patients with liver cirrhosis and identify diagnostic significance this parameter. Material methods. We have done research among chronic diseases (cirrhosis, hepatitis, non-alcoholic fatty disease) determined IL-6 plasma healthy people control group. Conclusion. revealed a statistically significant increase compared similar parameter comparison The degree increased was directly proportional severity pathological process. value...
Objective. To assess the possible impact of COVID-19 pandemic on attitudes Belarusian doctors toward vaccination.Materials and methods. A questionnaire survey has been conducted using Google Forms service for different specialties in Republic Belarus.Results. total 1815 from 7 regions Belarus participated survey. considerable part respondents (79,89%, or 1450 people) have a positive attitude to vaccination, 16,42% (298 – neutral, (3,69%, 67 negative towards vaccination. The highest...
Objective. To assess the state of systemic inflammatory response and humoral immune in middle-aged patients came through COVID-19 infection mild moderate severity. Materials methods. A cohort single-center study involving 83 severity (women - 69.9% (58 patients), men 30.1% (25 patients); median age 53 years [49; 56] was conducted over period 2022-2023. All underwent clinical examination, evaluation with determination IgG IgM antibodies to SARS-CoV-2 virus, as well concentration interleukins:...
Objective . To study the microbial diversity of respiratory microbiota in patients with undifferentiated pathological changes lungs. Materials and methods The biopsy material obtained during video-assisted thoracoscopic lung resection was conducted 36 lungs carried out by high-performance sequencing using MiSeq sequencer (Illumina, USA) a protocol based on analysis variable regions 16s rRNA gene. Results density pulmonary samples were studied. In all patient samples, dominant taxa at Phylum...
Liver cirrhosis is one of the top 10 causes death worldwide, and liver disease in five many developing countries. The treatment at various stages necessitates development new organ transplantation techniques. One these options cell therapy, which has lately been used to treat a wide range illnesses.
Background. There exists a bilateral relationship between the gut microorganisms and liver, so-called "gut microbiota-liver" axis. With progression of liver diseases decrease in function, there is change qualitative quantitative composition microbiota. Objective. To analyze microbiota profile level bilirubin, albumin, prothrombin patients with cirrhosis. Material methods. A prospective cohort single-center study 79 hospitalized cirrhosis was conducted, which included collection...
Molecular genetics researches have great value for understanding of an origin illnesses and their mechanisms. Modern genetic technologies given a new impulse in the decision problems treatment hereditary diseases multifactorial nature. One actual modern medicine is finding-out molecular bases predisposition to cardiovascular diseases. The review devoted questions importance carrying out biology studying pathology.
Aims: The paper aims at revealing the difference in change of Systemic Inflammation (SI) parameters blood plasma patients with Passing Infringements Brain Blood Circulation (PIBBC) and stroke during 10-day acute period. Study Design: Prospective cohort study.
Relevance. The first case of COVID-19 was registered in 2019. Several months later, the local outbreak became pandemic. only way to curb spread SARS-CoV-2 infection is mass vaccination that aims form a herd immunity. success depends on people’s acceptance, which might be problematic. review summarizes main barriers against COVID-19, categorizing people based their willingness vaccinate, and pointing out possible areas work overcome listed above. Aim. Analyze problem rejection COVID-19....