The urobiome is being actively studied, diagnostics are improved and new markers of inflammatory diseases the urinary tract searched for, despite fact that most microorganisms unidentified their functions remain not fully understood. aim study was to composition microbiota (urobiota) in patients with liver cirrhosis, depending on presence infection. Material methods. A prospective cohort single-center conducted 48 cirrhosis (30 men, 18 women), who, addition standard studies, underwent...

Objective. To demonstrate a clinical case of atypical ankylosing spondylitis. Materials and methods . Retrospective analysis the medical history patient hospitalized in Rheumatology Department Gomel City Clinical Hospital No. 1. Results. Ankylosing spondylitis is one most difficult to diagnose causes specific pain lower back. The social significance disease lies high level disability young people, decrease quality patients’ life. There are no diagnostic markers at an early stage disease....

Objective. To determine the composition of microbiota ascitic fluid in patients with liver cirrhosis and compare it intestinal urobiota. Materials methods . A cross-sectional single-center study was conducted for 5 hospitalized decompensated ascites who, along standard research methods, underwent metagenomic sequencing fluid, urine feces. High-throughput performed using a MiSeq genetic analyzer (Illumina, USA) protocol based on analysis variable regions 16s rRNA gene. The assignment...

Urinary tract infections (UTIs) are of considerable practical interest due to their high prevalence, presence complications in the form generalized infection with development sepsis, relapsing course, negative effects on mother and fetus pregnant women associated intensive use antibacterial drugs leading Clostridioides diffcile-associated colitis antibiotic resistance. The approaches treatment urinary undergoing changes. If earlier it was believed that urine is sterile detection bacteriuria...

The gut microbiome is a variable system that not only adapts to signals and information coming from humans, but also affects its host due complex of interactions living microorganisms, phages, viruses, plasmids, mobile genetic elements, molecules synthesized by including their structural elements (nucleic acids, proteins, lipids, polysaccharides), metabolites (signaling molecules, toxins, organic inorganic molecules) the human body. Modification or modulation correcting diet, intensity...

Objective. To analyze the structure and frequency of kidney pathology in liver cirrhosis according to sectional analysis study relationship between acute renal injury urinary tract infection.Materials methods. The design is mixed: descriptive analytical, which included conducting a retrospective case–control based on results protocols pathoanatomical autopsies basis state healthcare institution “Gomel Regional Clinical Pathoanatomical Bureau” for period January 2022 – July 2023 clinical,...

Purpose. To compare the gut microbiota in patients with an anamnesis of liver cirrhosis less than and more 10 years. Materials methods. A one-stage study metagenomic fecal sequencing 40 hospitalized were conducted, which 35 a history years 5 — High-throughput was performed using MiSeq genetic analyzer (Illumina, USA) protocol based on analysis 16s rRNA gene variable regions. The registered Clinicaltrials.gov (NCT05335213). Data Kraken2 algorithm. difference proportional composition...

Background. There exists a bilateral relationship between the gut microorganisms and liver, so-called "gut microbiota-liver" axis. With progression of liver diseases decrease in function, there is change qualitative quantitative composition microbiota. Objective. To analyze microbiota profile level bilirubin, albumin, prothrombin patients with cirrhosis. Material methods. A prospective cohort single-center study 79 hospitalized cirrhosis was conducted, which included collection...

Toxoplasmosis is an infectious disease, the causative agent of which Toxoplasma gondii - simplest, intracellular parasite, infects up to a third world’s population. Clinical manifestations toxoplasmosis in immunocompetent patients are characterized by lymphadenopathy syndrome, high level specific antibodies and favorable outcome. At same time, enlargement lymph nodes requires multidimensional differential diagnosis exclude other diseases. The article presents clinical case woman with...

Objective. To determine the possibilities of cytological method urine cellular sediment examination for diagnosis and differential renal urinary tract pathology in liver cirrhosis. Materials methods. A standard observational study 50 inpatients with cirrhosis was performed. Cytological preparations were prepared by liquid cytology cytocentrifugation methods after fixation Results. hospitalized patients revealed dysmorphic (leached) erythrocytes 31% cases, statistically significantly more...

Ascites is a common complication of liver cirrhosis associated with poor prognosis. The treatment ascites requires dietary sodium restriction and the judicious use diuretics. Management refractory in treatments repeat largevolumeparacentesis (LVP) or insertion transjugular intrahepatic portosystemic shunt (TIPS), assessment for transplantation. Potential new options include various vasoconstrictors, vasopressin V 2 receptor antagonists, peritoneo-vesical shunt.

AbstractPrimary hemochromatosis refers to a congenital autosomal recessive disease associated with mutation of the homeostatic iron regulator (HFE gene), whose pathogenetic mechanism is increased absorption in intestines, which leads excessive accumulation organs and tissues, mainly liver, pancreas, heart, pituitary gland, testicles. The consequence development fibrosis insufficiency these organs. Genotyping HFE gene mutations main method verification. presence C282Y/C282Y genotype...

The analysis of the late publications is evidence tendency to rising rectal cancer incidence in whole world. According data World Health Organization every year more than 500 thousand cases this disease are registered In structure oncologic rate takes second-third place both men and women goes second among oncopathology death reasons majority economically developed countries. adenomatous polypi known develop neoplasms. chain «adenoma - cancer» has been proved by numerous researches though...

Autoimmune liver disease is a heterogeneous group of diseases in which the body’s immune cells and antibodies are directed against its own components tissue. The main from this are: autoimmune hepatitis (AIH), primary biliary cholangitis (PBC), sclerosing cholangitis. Most often there classical monovariants disease, but some cases, manifestations two forms observed at once. term “overlap syndrome” used to describe such conditions. article presents clinical case combination PBC AIH, one most...

Psoriasis is a chronic non-infectious autoimmune disease, dermatosis, affecting mainly the skin. Usually psoriasis manifested by formation of red, excessively dry, raised spots above surface skin — so-called papules, which merge with each other, forming plaques. These papules their nature are sites inflammation and excessive proliferation lymphocytes, macrophages keratinocytes skin, as well angiogenesis.Psoriatic arthritis (arthopathic psoriasis) inflammatory disease joints, spine entheses,...

Цель. Провести сравнительный анализ способов стандартизации преаналитического лабораторного этапа цитологического исследования клеточного осадка мочи с расчетом экономической эффективности применяемых методов. Материалы и методы. Цитологические препараты были приготовлены использованием методов жидкостной цитологии (ЖЦ), цитоцентрифугирования (ЦЦ) простого центрифугирования (традиционного (ТЦ)). Было проанализировано 1930 образцов пациентов установленным диагнозом уротелиальной карциномы...