A5075896176- Urinary Tract Infections Management
- Asthma and respiratory diseases
- Cardiovascular Disease and Adiposity
- Eicosanoids and Hypertension Pharmacology
- Nephrotoxicity and Medicinal Plants
- Diabetes Treatment and Management
- Nitric Oxide and Endothelin Effects
- Antioxidant Activity and Oxidative Stress
- Hormonal Regulation and Hypertension
- Cardiac Fibrosis and Remodeling
- Acute Myocardial Infarction Research
- Blood Pressure and Hypertension Studies
- Peripheral Artery Disease Management
- Angiogenesis and VEGF in Cancer
- GDF15 and Related Biomarkers
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Computational Drug Discovery Methods
- Pharmaceutical studies and practices
- Potassium and Related Disorders
- Tissue Engineering and Regenerative Medicine
- Peripheral Neuropathies and Disorders
- Inflammatory Bowel Disease
- Fatty Acid Research and Health
- Atherosclerosis and Cardiovascular Diseases
- Chemotherapy-induced cardiotoxicity and mitigation
Kharkiv Medical Academy of Postgraduate Education
2019-2022
Masitinib is an oral tyrosine kinase inhibitor that selectively targets mast cell activity and platelet-derived growth factor receptor (PDGFR) signaling, both of which are implicated in various mechanisms asthma pathogenesis.Assessment masitinib as add-on to standard maintenance therapy compared with placebo the treatment corticosteroid-dependent severe asthma.We conducted a randomized (2:1), placebo-controlled study (6 mg/kg/d) adults uncontrolled by high dose inhaled corticosteroids...
Accumulating evidence indicates that cytokines play an important role in the pathogenesis of chronic heart failure. The review considers participation proinflammatory (factors-necroses-tumors-α, interleukin 1β and 6) pathophysiological processes congestive failure, as well influence on cardiac contractility, hypertrophy remodeling left ventricle heart, apoptotic, fibrotic processes.
<b>Background:</b> Study AB07015 evaluated oral masitinib (6 mg/kg/d) in severe persistent asthma, uncontrolled by high-dose ICS/LABA and corticosteroids (OCS) (≥7.5 mg/d), irrespective of baseline eosinophil levels. <b>Method:</b> Eligible adult patients (pts) were treated for 36 weeks (with possible blinded extension until at least week-96). Primary endpoint was reduction annualized asthma exacerbation rate (SAER) overall exposure (W0–W96). A key subgroup defined as pts with initial count...
The present study aimed to investigate the immunohistochemical characteristics of bladder (UB) rats with infravesical obstruction (IVO) after intraperitoneal administration biologically active compositions (BACs) (conditioned media (CM) native and cryopreserved cultures mantle gliocytes (MG) obtained from spinal ganglia (SG). Methods. IVO was reproduced by surgical ligation. BACs were intraperitoneally injected for 10 days. relative area expression S100 protein actin, as markers nerve smooth...
Abstract Funding Acknowledgements Type of funding sources: None. Background Arrhythmia is among the most common and severe myocardial infarction complications. Myeloperoxidase as an important immune factor can be linked to atrial fibrillation (AF) development. Previous studies indicated myeloperoxidase (MPO) a significant mortality predictor in ST-segment elevation (STEMI). The MPO role prognosis for adverse clinical outcomes, fibrillations STEMI patients remains not fully understood....
Resistance to common groups of antibiotics has been increasing in the treatment urinary tract infections worldwide. In United States, CDC estimated that more thаn 2 million and 23,000 deaths are due antibiotic resistance each year. Europe, an еstimated 25,000 attributable antibiotic-rеsistant infections. By 2050, it is will cause 10 every year.At EU/EEA level, than half (58.2%) E. coli isolates reported EARS-Net for 2017 were resistant at least one antimicrobial under regular surveillance,...
Resistance to common groups of antibiotics has been increasing in the treatment urinary tract infections worldwide. CDC estimated that more thаn 2 million and 23,000 deaths are due antibiotic resistance each year. By 2050, it is will cause 10 every CKD assоciated with significant majоr infectiоus complicatiоns, which оccur at rаtes 3 4 times generаl population. Infection an importаnt mоrbidity mоrtality amоng patients kidney failurе sеcond lеading causе death following CVD.
Abstract Background Chronic kidney disease (CKD) is assоciated with significant majоr infectiоus complicatiоns, which оccur at rаtes 3 to 4 times the generаl population. Urinary tract infection (UTI) one of major nosocomial infections, reaching 150 million episodes per year and accounting for $6 billion. Pyelonephritis leading cause hospitalization among all UTIs. Recent years, steady increase in rate uropathogen resistance commonly prescribed antibiotics associated plasmid-mediated genes...
Abstract. The research aimed to study the morphological characteristics of kidneys after intraperitoneal administration biologically active compositions (BACs) in rats with infravesical obstruction (IVO).
 Methods. IVO was reproduced by surgical ligation. BACs were injected intraperitoneally for 10 days. morphometric parameters determined examining their structure (the areas renal corpuscle, glomerulus, cavity glomerular capsule, outer and inner diameters tubules, tubular index,...
В руководстве Европейского общества кардиологов по сердечной недостаточности 2016 года был введен термин «сердечная недостаточность с промежуточной фракцией выброса» для обозначения пациентов недостаточностью и незначительно сниженной выброса 40–49 %. Сегодня установлено, что около 20 % попадают в эту категорию. Доказано, ишемическая болезнь сердца является одним из ведущих факторов формирования прогрессирования диастолического нарушения левого желудочка. Более чем у 90 ишемической болезнью...
IDF has estimated that approximately 463 million adults (20-79 years) were living with diabetes; by 2045 this will rise to 700 million. Diabetes caused 4.2 deaths. is one of the leading causes chronic kidney disease (CKD). DM induces a wide range damage can be classified as follows: diabetic nephropathy (DN), (DKD) and non-diabetic renal (NDRD). The spectrum NDRD includes diseases such IgA nephropathy, membranous urinary tract infections etc., are requiring specific treatments.