A5000512651- Urinary Tract Infections Management
- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Nephrotoxicity and Medicinal Plants
- Healthcare Systems and Public Health
- Antibiotic Resistance in Bacteria
- Heart Rate Variability and Autonomic Control
- Diabetes Treatment and Management
- Cardiac pacing and defibrillation studies
- Blood Pressure and Hypertension Studies
- Galectins and Cancer Biology
- Cardiac electrophysiology and arrhythmias
- Pancreatic function and diabetes
- Biomarkers in Disease Mechanisms
- Human Health and Disease
- Diet, Metabolism, and Disease
- Chronic Kidney Disease and Diabetes
- Acute Myocardial Infarction Research
- Cardiovascular Disease and Adiposity
- Potassium and Related Disorders
- Metabolism and Genetic Disorders
- Gout, Hyperuricemia, Uric Acid
- Cardiovascular Health and Disease Prevention
Kharkiv National Medical University
2023-2024
V. N. Karazin Kharkiv National University
2018-2023
Kharkiv Medical Academy of Postgraduate Education
2012-2021
The University of Texas Southwestern Medical Center
2021
Abstract Background Recent cardiovascular outcome trials have shown that sodium–glucose co-transporter 2 (SGLT2) inhibitors slow the progression of chronic kidney disease (CKD) in patients with type diabetes at high risk. Whether these benefits extend to CKD without or is unknown. The Dapagliflozin and Prevention Adverse Outcomes (DAPA-CKD) trial (NCT03036150) will assess effect SGLT2 inhibitor dapagliflozin on renal events a broad range diabetes. Methods DAPA-CKD randomized, double-blind,...
The Dapagliflozin and Prevention of Adverse outcomes in Chronic Kidney Disease (DAPA-CKD; NCT03036150) trial was designed to assess the effect sodium-glucose co-transporter 2 (SGLT2) inhibitor dapagliflozin on kidney cardiovascular events participants with CKD without type diabetes (T2D). This analysis reports baseline characteristics those recruited, comparing them enrolled other trials.In DAPA-CKD, 4304 a urinary albumin:creatinine ratio (UACR) ≥200 mg/g estimated glomerular filtration...
Background : Increased multidrug resistance of extended-spectrum beta-lactamases (ESBLs) compromises the efficacy treatment urinary tract infections. Objective The objective this study is to determine prevalence ESBL-producing uropathogens from hospitalized patients with chronic pyelonephritis and identify presence genes involved in resistance. Methods A cross-sectional 105 pyelonephritis, treated Kharkiv City Clinical Emergency Hospital, Ukraine was carried. Bacterial isolates were...
Background. The prevalence of chronic heart failure in the world is increasing; however, it stabilizing developed countries. One reasons for this stabilization an improvement acute coronary syndrome treatment and revascularization. Revascularization patients with syndromes without signs left ventricular dysfunction less effective. promising methods assessing detection electrical mechanical dyssynchrony myocardium (DM). However, has not been sufficiently studied artery (CA) disease. purpose...
Background. A promising method for early detection of myocardial dysfunction is the evaluation mechanical dyssynchrony left ventricular myocardium, prognostic value which in diagnosis 3-vessel lesions was shown only a single study and requires further confirmation. Purpose – to assess relationship between number affected coronary arteries presence its significance predicting patients with heart disease. Materials Methods. 134 who underwent angiography revascularization were included study....
Introduction. Defining a treatment strategy for patients with stable coronary heart disease will require the development of personalized criteria, among which assessment myocardial dyssynchrony is considered promising. The aim study was to evaluate effect revascularization arteries on indicators mechanical in disease. Materials and methods. included 121 disease, who were assessed before 2 weeks after revascularization. main group 48 dyssynchrony, comparison 73 without dyssynchrony. Complete...
Chronic kidney disease (CKD) affects up to 10 % of adults worldwide. Since February 24, 2022, at least 12 million people that is equivalent 27 the Ukrainian population 44.1 have fled their homes. However, according registry analysis across eight European countries, among 14,436 migrants who visited health clinics, only 1.5 had CKD. Such low prevalence may mean healthy tend leave affected zones while sicker and older individuals stay behind. Compared available data on impact natural...
Abstract Funding Acknowledgements Type of funding sources: None. Introduction. Recent randomized controlled trials have shown that in heart failure (HF) patients with reduced left ventricle ejection fraction (HFrEF) atrial fibrillation (AF) ablation reduces hospitalization and mortality due to HF compared medical therapy (MT). However, only few studies examined outcomes catheter (CA) for AF preserved (HFpEF). Purpose. To compare the effect on chronic fraction. Methods. Our prospective study...
The aim of the study is to determine bacterial susceptibility-resistance levels uropathogens depending on expression different types plasmid-mediated resistance genes.
 Methods. A cross-sectional of105 patients with chronic pyelonephritis was carried. Screening for presence genes performed by polymerase chain reaction. antimicrobial susceptibility isolates determined Kirby Bauer disk diffusion method Mueller–Hinton agar-containing plates. size zone around each interpreted as sensitive,...
Использование в клинической практике тропонинов привело к прорыву диагностике инфаркта миокарда (ИМ), однако до настоящего времени остается причиной и большого количества ошибочных диагнозов из-за неправильной оценки получаемых результатов тропониновых тестов. Сердечный тропонин (cTn) представляет собой комплекс, состоящий из трех субъединиц. Поскольку сердечные тропонины I (cTnI) T (cTnT) являются компонентами сократительного аппарата миокардиальных клеток экспрессируются почти...
The aim: To study the predictive power of demographic, hemodynamic and electrocardiographic factors for atrial fibrillation recurrence after radiofrequency ablation (RFA) in patients with chronic heart failure. Materials methods: Study included 120 patients, aged 59,80±10,08 years old failure preserved left ventricular ejection fraction who were undergo RFA due to (AF). A standard 12-lead electrocardiogram (ECG) was registered. Before procedure echocardiographic parameters obtained. After 12...
CERTAIN CRITERIA OF RENAL AFFECTION IN CASE COPD. Ospanova T., Semydotska Zh., Veremeyenko O., Avdeyeva O. Kharkiv national medical university, Kharkiv, Ukraine Abstract . Chronic pulmonary problems belong to the group of leading diseases in modern society. Often severity course and prognosis chronic pathology lungs are determined by extrapulmonary manifestations disease. Nephrological aspects lung poorly studied. In this clinical research, we have examined 27 patients with COPD II-nd III-rd...
Аннотация.В статье приведены данные исследования по изучению нарушений обмена ксантинов у больных хронической сердечной недостаточностью (ХСН) в зависимости от наличия или отсутствия них сопутствующей болезни почек (ХБП) на разных стадиях заболевания.Отмечено значимое повышение активности ксантиноксидазы с болезнью почек, что доказывает изменение метаболизма данной категории пациентов сторону оксидазного пути образования мочевой кислоты.Продемонстрировано негативное влияние клиническое...
Objective: Treatment-related reductions in microalbuminuria (MAU) are associated with a reduced incidence of cardiovascular events and reduction progression to end-stage renal disease hypertensive patients, but if MAU correlates regression left ventricular hypertrophy (LVH) is still insufficiently studied. Our goal was assess changes the level its relationship LVH during antihypertensive treatment. Design method: 443 patients were treated losartan 50–100 mg plus hydrochlorothiazide 12.5–25...
In the present review considers mechanisms of resistance induced by plasmids and associated with development genes