A5058400415- Chronic Obstructive Pulmonary Disease (COPD) Research
- Long-Term Effects of COVID-19
- Asthma and respiratory diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- COVID-19 Clinical Research Studies
- Pediatric health and respiratory diseases
- Neurological Disorders and Treatments
- Ultrasound in Clinical Applications
- Pneumothorax, Barotrauma, Emphysema
- Human Health and Disease
- Pleural and Pulmonary Diseases
- Vasculitis and related conditions
- Respiratory viral infections research
- High Altitude and Hypoxia
- Respiratory Support and Mechanisms
- Autopsy Techniques and Outcomes
- Cardiac Health and Mental Health
- Cystic Fibrosis Research Advances
- Ultrasound and Hyperthermia Applications
- IgG4-Related and Inflammatory Diseases
- Fibromyalgia and Chronic Fatigue Syndrome Research
- COVID-19 and healthcare impacts
- COVID-19 diagnosis using AI
- Chronic Disease Management Strategies
- Trauma and Emergency Care Studies
Kharkiv National Medical University
2023-2024
Kharkiv Medical Academy of Postgraduate Education
2015-2023
City Clinical Hospital No. 2
2022
Kharkiv Regional Clinical Psychiatric Hospital No 3
2020
Weatherford College
2019
Masitinib is an oral tyrosine kinase inhibitor that selectively targets mast cell activity and platelet-derived growth factor receptor (PDGFR) signaling, both of which are implicated in various mechanisms asthma pathogenesis.Assessment masitinib as add-on to standard maintenance therapy compared with placebo the treatment corticosteroid-dependent severe asthma.We conducted a randomized (2:1), placebo-controlled study (6 mg/kg/d) adults uncontrolled by high dose inhaled corticosteroids...
Background Post-COVID-19 syndrome (PCS) has been increasingly recognized as an emerging problem: 50% of patients report ongoing symptoms 1 year after acute infection, with most typical manifestations (fatigue, dyspnea, psychiatric and neurological symptoms) having potentially debilitating effect. Early identification high-risk candidates for PCS development would facilitate the optimal use resources directed to rehabilitation COVID-19 convalescents. Objective To study in-hospital clinical...
<b>Background:</b> Study AB07015 evaluated oral masitinib (6 mg/kg/d) in severe persistent asthma, uncontrolled by high-dose ICS/LABA and corticosteroids (OCS) (≥7.5 mg/d), irrespective of baseline eosinophil levels. <b>Method:</b> Eligible adult patients (pts) were treated for 36 weeks (with possible blinded extension until at least week-96). Primary endpoint was reduction annualized asthma exacerbation rate (SAER) overall exposure (W0–W96). A key subgroup defined as pts with initial count...
Background. Today's latest infection, COVID-19, remains an urgent problem of the Ukrainian healthcare system, which requires further efforts to develop effective treatment strategies, especially considering potential exacerbation comorbidities. Objective. Develop and approve a multivariate model effectiveness treating mild COVID-19 in patients with comorbidities, using Aminocaproic acid comparison nirmatrelvir/ritonavir symptomatic therapy as examples. Methods. The modeling was based on...
Phenol-containing wastewater is characterized by an extremely diverse mixture of organic substances, the oxidation which should not involve a separate pure culture mesophilic bacteria, but complex microorganisms, joint activity ensures complete biological purification wastewater. Biochemical (microbial) method Putilinа N.T. meets requirements for cleaning from phenol without prior dilution. The use methods directed variability microorganisms in work made it possible to grow highly active,...
Background. A child’s body as a functional system is formed starting from the fetal period. Therefore, analysis of even distant in time situations allows to identify factors that affect functioning present and, possibly, effectiveness chemoprophylaxis children. Materials and methods. To study presence correlation between postembryonic ontogeny tuberculosis children, an was carried out 300 patients aged 0 17 years early period primary infection, who underwent 3-month course with isoniazid....
The aim was to study the clinical features of post-COVID-19 interstitial lung disease (ILD) and determine prospects for use antifibrotic drug nintedanib in patients with moderate severe COVID-19. Material methods. A prospective cohort conducted 266 (≥ 18 years old) COVID-19 who were hospitalized discharged after treatment at Volyn Regional Clinical Hospital between September November 2021. design included telephone contact one year hospital discharge collect complaints history data related...
It was established that the mortality rate is 1.87% among discharged patients (n=266) one year after suffering moderate and severe COVID-19. In 9.39% (n=25) diagnosis of post-COVID-19 interstitial lung disease (ILD) for first time. 76% (n=19) ILD presented as a separate respiratory pathology in form syndrome COVID-19, 16% (n=4) debut systemic connective tissue due to 8% (n=2) manifestation chronic against background COVID-19 not diagnosed time before pandemic. ILD, radiological pattern (RP)...
In patients (n=31) who died from severe COVID-19 in the acute (average duration of illness 17.31 days, age deceased 66.1±8.8 years) and post-acute period 43.22 67,0±5.9 disease, presence capillary congestion (CC) 77,4%, pulmonary fibrosis (PF) 32,2%, hemorrhages 38,7%, thrombosis small veins 25,8%, organizing pneumonia 41,93%, 16,1% bacterial fungal (Aspergillus) coinfection can be observed histopathologically. Diffuse alveolar damage was noted 90.32%. The probability occurrence CC is...
The epidemic of gunshot wounds and injuries as a result the war with Russia continues to grow. From February 24, 2022 18, 2023, in Pulmonology Department Volyn Regional Clinical Hospital, rate hospitalized military patients chest injury due mine-explosive wounds, shrapnel bullet stub-cut amounted 19.3% all pulmonological diseases soldiers that were received during this year (n=88). Penetrating occurred 41.1% cases, non-penetrating blunt (including behind armor trauma) 23.5% trauma soft...
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War has been declared to mankind, the initiator and enemy of which become a new disease caused by coronavirus (SARS Cov-2 RNA). Victory in this war, that is, survival recovery each patient depends on solution many scientific, technical, organizational clinical problems, particular, more optimal understanding morphological clinical-radiation picture disease. The initial diagnostic hypothesis for COVID-19 is based an influenza-like condition molecular tests such as polymerase chain reaction...
<b>Background:</b> Effect of inhaled glucocorticosteroids (IGCC) on the course disease and quality life in patients with bronchiectasis remission, has not yet been studied. <b>Aim:</b> Investigate efficacy combined drugs (IGCC + long-acting beta2-agonist) life, microbiological functional parameters mixed remission. <b>Methods:</b> A 6-month study 45 was researched. Mixed verified by high resolution CT scan chest. Depending dose corticosteroids were randomized: fluticasone propionate 250 mcg...
Взаимодействие между легким и сердцем – обширная сложная с клинической точки зрения тема, поскольку расстройства одного часто влияют способствуют расстройствам другого. Выявление хронической обструктивной болезни легких (ХОБЛ) у пациентов известной ишемической болезнью сердца (ИБС) наоборот очень важно из-за более низкого качества жизни, высокой госпитализации в итоге смертности таких больных. Настоящий анализ фокусируется на сердечно-сосудистом вкладе симптомы ХОБЛ их связи диагностическим...
Аннотация.Острый респираторный дистресс-синдром и дыхательная недостаточность являются основными угрожающими состояниями у больных COVID-19.Основной причиной является, прежде всего, нарушение перфузии легких.Неинвазивная вентиляция легких может устранить гипоксемию снизить инспираторные усилия.Использование механической вентиляции для предотвращения самоиндуцированного повреждения (P-SILI) рассматривается как вариант оптимизации.Ведущей характеристикой прогрессирования COVID-19 является...
Patients with chronic obstructive pulmonary disease (COPD) are characterized by a variety of comorbid conditions, including both somatic (arterial hypertension, atherosclerosis, coronary heart disease, bronchial asthma, malignant neoplasms, diabetes mellitus, obesity, etc.) and mental (depressive disorders, suicide attempts). Against the background various diseases respiratory system, endocrine, metabolic risks exacerbations COPD increase. The leading unifying mechanism these conditions is...
Background. The study of pathogenesis and the search for factors that lead to mortality from severe COVID-19 disability due post-COVID interstitial lung disease with permanent physiological functional deficits is an urgent unsolved problem today. purpose was investigate histopathology in patients who died acute post-acute period disease, determine significance histological changes parenchyma depending on gender, duration use or non-use respiratory support. Materials methods. included results...