A5068354332- Muscle metabolism and nutrition
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Exercise and Physiological Responses
- Cardiovascular Effects of Exercise
- Adipose Tissue and Metabolism
- SARS-CoV-2 and COVID-19 Research
- Vitamin C and Antioxidants Research
- COVID-19 Clinical Research Studies
- Apelin-related biomedical research
- Renal Diseases and Glomerulopathies
- Genetics and Physical Performance
- Genetic Syndromes and Imprinting
- Complement system in diseases
- Kruppel-like factors research
- Cancer, Hypoxia, and Metabolism
- Metabolism, Diabetes, and Cancer
- Muscle and Compartmental Disorders
Universidade Federal de São Paulo
2019-2025
Exertional rhabdomyolysis (ER) is one of the severe complications attributable to prolonged and repeated muscle exercises most commonly seen in military personnel elite athletes. In personnel, ER usually results from long strenuous nature training may sometimes result outcomes, such as acute kidney injury (AKI) cardiac arrhythmias. Besides, tissue injuries impair physical function, decreasing strength flexibility delaying soreness inflammation. The existing literature has studied genetic...
Paroxysmal nocturnal hemoglobinuria (PNH) is a rare clonal hematopoietic stem cell disease characterized by acquired abnormalities in the phosphatidylinositol glycan class A (PIG-A) gene. This study analyzed PIG-A gene using polymerase chain reaction (PCR) followed Sanger sequencing of 31 Brazilian patients with PNH, including 23 classical PNH and 8 subclinical (aplastic anemia clone). diverse spectrum variants was identified, encompassing insertions, deletions, single-base substitutions....
Significance Aerobic exercise elicits an integrated metabolic response that involves multiple tissues and confers beneficial effects to health. Here we found this integrative energy-sensing pathways in muscle fat circulating factors lead the upregulation of type III endoribonuclease DICER adipose tissue consequent increase microRNAs. Upon upregulation, microRNA-203-3p inhibit glucose utilization by cells favor oxidative metabolism. In turn, supports exercised with adequate substrate...
The kinin B1 receptor (B1R) plays a role in inflammatory and metabolic processes. B1R deletion (B1−/−) protects mice from diet-induced obesity improves insulin leptin sensitivity. In contrast, genetic reconstitution of exclusively adipose tissue reverses the lean phenotype B1−/− mice. To study cell-nonautonomous nature these effects, we transplanted epididymal white (eWAT) wild-type donors (B1+/+) into (B1+/+→B1−/−) compared them with autologous controls (B1+/+→B1+/+ or B1−/−→B1−/−). We then...
Renin-angiotensin system (RAS) and kallikrein-kinin (KKS) have a different site of interaction modulate vascular tone inflammatory response as well on exercise adaptation, which is modulated by exercise-induced cytokines. The aim the study was to evaluate role ACE I/D BDKRB2 +9/-9 polymorphism cytokine response. Seventy-four male marathon finishers, aged 30 55 years, participated in this study. Plasma levels cytokines were determined 24 h before, immediately after, 72 after São Paulo...
Abstract Objective and design: Several proteases have drawn attention as potential targets to control the SARS-CoV-2 infection (COVID-19), thus circulating enzymatic activity RAS regulation in severe hospitalized patients still remain be determined. Material or subjects: 164 with COVID-19-like symptoms were grouped according severity of (COVID-19 negative, mild, moderate severe). Methods: Patients subjected biochemical analyzes activities ACE2, ACE, DPPIV, PREP CAT L, evaluated serum...
Abstract Exertional rhabdomyolysis (ERM), a condition often associated with strenuous exercise, common practice in the military activities, can be defined as process of injury and rupture muscle cell membranes, leakage its components into blood stream. Creatine kinase (CK) has been extensively used for ERM diagnosis, albeit several studies reported discrepancy between CK levels clinical signs or symptoms. In this study, we analyzed biochemical profile blood, urinary proteome ten marine...