A5018677202- Adipose Tissue and Metabolism
- Muscle metabolism and nutrition
- Cardiovascular and exercise physiology
- Cancer, Hypoxia, and Metabolism
- Diabetes Management and Research
- Vitamin K Research Studies
- Vitamin C and Antioxidants Research
- Electrolyte and hormonal disorders
- Muscle Physiology and Disorders
- Metabolism, Diabetes, and Cancer
- Sirtuins and Resveratrol in Medicine
- Diabetes, Cardiovascular Risks, and Lipoproteins
University of Copenhagen
2014-2022
Danish Diabetes Academy
2017
Odense University Hospital
2017
High‐intensity interval training ( HIT ) is known to increase mitochondrial content in a similar way as endurance [60–90% of maximal oxygen uptake VO 2peak )]. Whether increases the mitochondria's ability oxidize lipids currently debated. We investigated effect on fat oxidation skeletal muscle and adipose tissue. Mitochondrial oxidative phosphorylation OXPHOS capacity, substrate sensitivity K m app ), were measured tissue healthy overweight subjects before after 6 weeks (three times per week...
Aging decreases skeletal muscle mass and strength, but aerobic resistance exercise training maintains function. NAD+ is a coenzyme for ATP production required substrate enzymes regulating cellular homeostasis. In muscle, mainly generated by the salvage pathway in which nicotinamide phosphoribosyltransferase (NAMPT) rate-limiting. NAMPT with age human increases levels young men. However, whether distinct modes of increase both old people unknown. We assessed effects 12 weeks on abundance...
Abstract Aim Metabolic health may deteriorate with age as a result of altered body composition and decreased physical activity. Endurance exercise is known to counter these changes delaying or even preventing onset metabolic diseases. High‐intensity interval training ( HIIT ) time efficient alternative regular endurance exercise, the aim this study was investigate benefit in older subjects. Methods Twenty‐two sedentary male (n = 11) female subjects aged 63 ± 1 years performed three...
Introduction: High intensity interval training (HIIT) has shown to be as effective moderate endurance improve metabolic health. However, the current knowledge on effect of HIIT in older individuals is limited and it uncertain whether adaptations are sex specific. The aim was investigate effects mitochondrial respiratory capacity content females males. Methods: Twenty-two sedentary males (n = 11) completed 6 weeks supervised 3 days per week. consisted 5 × 1 min cycling (124 ± 3% max power...
Significance Aerobic exercise elicits an integrated metabolic response that involves multiple tissues and confers beneficial effects to health. Here we found this integrative energy-sensing pathways in muscle fat circulating factors lead the upregulation of type III endoribonuclease DICER adipose tissue consequent increase microRNAs. Upon upregulation, microRNA-203-3p inhibit glucose utilization by cells favor oxidative metabolism. In turn, supports exercised with adequate substrate...
Extreme endurance exercise provides a valuable research model for understanding the adaptive metabolic response of older and younger individuals to intense physical activity. Here, we compare wide range physiologic parameters in two cohorts seven trained men, age 30 ± 5 years or 65 6 years, before after participants travelled ≈3000 km by bicycle over 15 days.Over 15-day intervention, lost 2-3 kg fat mass with no significant change body weight. V̇O2 max did not cyclists, but decreased (p =...
Ceramide and diacylglycerol are linked to insulin resistance in rodents, but humans the data inconsistent. Insulin is frequently observed with aging, role of ceramide not clarified. Training improves metabolic health and, therefore, we aimed elucidate influence age high-intensity interval training (HIIT) on content muscle. Fourteen young (33 ± 1) 22 older (63 overweight obese subjects performed 6 weeks HIIT three times a week. Maximal oxygen uptake body composition were measured muscle...
Ceramide and diacylglycerol (DAG) may be involved in the early phase of insulin resistance but data are inconsistent man. We evaluated if an increase sensitivity after endurance training was accompanied by changes these lipids skeletal muscle. Nineteen first-degree type 2 diabetes Offsprings (Offsprings) (age:<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mn fontstyle="italic">33.1</mml:mn><mml:mo>±</mml:mo><mml:mn fontstyle="italic">1.4</mml:mn></mml:math> yrs;...
Reduced insulin sensitivity is observed with aging and often explained by decreased physical activity. The mechanisms involved are not clarified, but bioactive lipids may play a role. We aimed to evaluate the influence of age cardiorespiratory fitness on ceramide diacylglycerol content in muscle key proteins lipid metabolism signaling. Healthy males were stratified into trained untrained groups including 27 young (23.2 ± 0.3 years) 33 aged (65.2 0.6 years). Maximal oxygen uptake body...