A5037733915- Cystic Fibrosis Research Advances
- Cellular transport and secretion
- Neonatal Respiratory Health Research
- Immune Cell Function and Interaction
- Tracheal and airway disorders
- Extracellular vesicles in disease
- Evolution and Genetic Dynamics
- Studies on Chitinases and Chitosanases
- Viral gastroenteritis research and epidemiology
- Click Chemistry and Applications
- Animal Genetics and Reproduction
- Child Nutrition and Water Access
- dental development and anomalies
- Bacterial biofilms and quorum sensing
- Plant Virus Research Studies
- Bladder and Urothelial Cancer Treatments
- HIV Research and Treatment
- MicroRNA in disease regulation
- Autism Spectrum Disorder Research
- Immunodeficiency and Autoimmune Disorders
- Bacteriophages and microbial interactions
- Bone and Dental Protein Studies
- Oral microbiology and periodontitis research
- Tissue Engineering and Regenerative Medicine
- Reproductive System and Pregnancy
University of Coimbra
2024
National Institute of Health Dr. Ricardo Jorge
2015-2023
University of Lisbon
2013-2023
Escola Superior de Saúde Egas Moniz
2023
It has been argued that bacterial cells may use their temperate viruses as biological weapons. For instance, a few among population of lysogenic could release the virus and kill susceptible non-lysogenic competitors, while clone mates would be immune. Because replicate inside victims upon infection, this process amplify number in arena. Sometimes, however, spare recipient from death by establishing themselves dormant state cells. This phenomenon is called lysogenization and, for some such λ...
The peripheral protein quality control (PPQC) checkpoint removes improperly folded proteins from the plasma membrane through a mechanism involving E3 ubiquitin ligase CHIP (carboxyl terminus of Hsc70 interacting protein). PPQC limits efficacy some cystic fibrosis (CF) drugs, such as VX-809, that improve trafficking to misfolded mutants CF transmembrane conductance regulator (CFTR), including F508del-CFTR, which retains partial functionality. We investigated in lung epithelial cells with...
Background: Upper tract urothelial carcinoma (UTUC) is a rare malignancy, accounting for 5-10% of cancers, and traditionally managed with radical nephroureterectomy (RNU). Although RNU offers effective oncological control, it associated significant morbidity, including chronic kidney disease cardiovascular complications. Recent advancements in endoscopic technology have enabled minimally invasive approaches, particularly low-risk tumors, emphasizing preservation reducing treatment-related...
Cystic fibrosis (CF), the most common inherited disease in Caucasians, is caused by mutations CFTR chloride channel, frequent of which Phe508del. Phe508del causes not only intracellular retention and premature degradation mutant protein, but also defective channel gating decreased half-life when experimentally rescued to plasma membrane (PM). Despite recent successes functional rescue several with small-molecule drugs, folding-corrector/gating-potentiator drug combinations approved for...
In cystic fibrosis the most common disease-causing mutation is F508del, which causes not only intracellular retention and degradation of CFTR, but also defective channel gating decreased membrane stability small amount that reaches plasma (PM). Thus, pharmacological correction mutant CFTR requires targeting multiple cellular defects in order to achieve clinical benefit. Although molecule compounds have been identified commercialized can correct its folding or gating, an efficient F508del at...
Information regarding microbiological hazards in edible macroalgae and halophytes is scarce, standard methods for detecting norovirus vegetables have not yet been validated these types of food products. Accordingly, the suitability NF EN ISO 15216-2 method was evaluated using 57 samples collected along Western coast mainland Portugal. The presence Salmonella 46 also tested to confirm potential hazard. viral extraction process 72% samples, with results showing that suitable green red...
Recent developments in CFTR modulator drugs have had a significant transformational effect on the treatment of individuals with Cystic Fibrosis (CF) who carry most frequent F508del-CFTR mutation at least one allele. However, clinical effects these revolutionary remain limited by their inability to fully restore plasma membrane (PM) stability rescued mutant channels. Here, we shed new light molecular mechanisms behind reduced half-life PM airway cells. We describe that YES1 protein kinase is...
Cystic fibrosis (CF), the most common inherited disease in Caucasians, is caused by mutations CFTR, frequent of which F508del. F508del causes ER retention and degradation mutant CFTR protein, but also defective channel gating decreased half-life at plasma membrane. Despite recent successes with small-molecule modulator drugs, folding-corrector/gating-potentiator drug combinations approved for CF individuals carrying F508del-CFTR have sometimes produced severe side effects. Previously, we...
Incisor Molar Hypomineralisation (IMH) is a qualitative alteration affecting one or more first permanent molars (FMPs) with the possible involvement of incisors, and associated several dental complications. The aim this study was to assess impact IMH on quality life (QoL) children/adolescents. A total 56 children attending Egas MonizDental Clinic (EMDC) were enrolled, 27 females 29 males, most common age 11 years. Most them had mild moderate degree IMH. children's not significant.