A5001070802- Diabetes, Cardiovascular Risks, and Lipoproteins
- Advanced Glycation End Products research
- Adipokines, Inflammation, and Metabolic Diseases
- Sodium Intake and Health
- Diet and metabolism studies
- Blood Pressure and Hypertension Studies
- Cholesterol and Lipid Metabolism
- Colorectal Cancer Surgical Treatments
- COVID-19 and healthcare impacts
- Women's cancer prevention and management
- Cancer, Lipids, and Metabolism
- Tryptophan and brain disorders
- Alzheimer's disease research and treatments
- Antiplatelet Therapy and Cardiovascular Diseases
- Sexual Differentiation and Disorders
- Liver Disease Diagnosis and Treatment
- Lung Cancer Diagnosis and Treatment
- Atrial Fibrillation Management and Outcomes
- Global Cancer Incidence and Screening
- Alcohol Consumption and Health Effects
- Cancer Immunotherapy and Biomarkers
- Hepatocellular Carcinoma Treatment and Prognosis
- Hormonal and reproductive studies
- Acute Myocardial Infarction Research
- Atherosclerosis and Cardiovascular Diseases
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2017-2023
Instituto Nacional do Câncer
2023
University of Washington
2021-2022
IPO Porto
2021
Hospital Israelita Albert Einstein
2021
Universidade de São Paulo
2015-2017
Regular exercise prevents and regresses atherosclerosis by improving lipid metabolism antioxidant defenses. Exercise ameliorates the reverse cholesterol transport (RCT), an antiatherogenic system that drives from arterial macrophages to liver for excretion into bile feces. In this study we analyzed role of aerobic on in vivo RCT expression genes proteins involved flux inflammation peritoneal macrophages, aortic arch wild type mice. Twelve-week-old male mice were divided sedentary trained...
Objective: Expression of the extrahepatic acute-phase protein Saa3 (serum amyloid A3) increases in response to acute and chronic inflammatory stimuli is elevated adipose tissue macrophages obese mice. A recent report suggested that proatherogenic male ApoE −/− Because our previous observation female but not Saa3-deficient mice are protected from obesity, inflammation, hyperlipidemia, we sought determine whether differentially modulates atherosclerosis both sexes. Approach Results: To promote...
This study investigated the influence of sodium restriction and antihypertensive drugs on atherogenesis utilizing hypertensive (H) low-density lipoprotein-receptor knockout mice treated or not with losartan (Los) hydralazine (Hyd) fed low-sodium (LS) normal-sodium (NS) chow. Despite reducing blood pressure (BP) H-LS mice, LS diet caused arterial lipid infiltration due to increased plasma total cholesterol (TC) triglycerides (TG). Los Hyd reduced BP effectively prevented injury, likely by TG...
Background: Advanced glycation endproducts elicit inflammation. However, their role in adipocyte macrophage infiltration and the development of insulin resistance, especially absence deleterious biochemical pathways that coexist diabetes mellitus, remains unknown. We investigated effect chronic administration advanced glycated albumin (AGE-albumin) healthy rats, associated or not with N-acetylcysteine (NAC) treatment, on sensitivity, adipose tissue transcriptome polarization. Methods: Male...
Antisense oligonucleotides (ASOs) against Ldl receptor (Ldlr-ASO) represent a promising strategy to promote hypercholesterolemic atherosclerosis in animal models without the need for complex breeding strategies. Here, we sought characterize and contrast mice given Ldlr-ASO with those bearing genetic Ldlr deficiency. To atherosclerosis, male female C57Bl6/J were either weekly injections of (5 mg/kg once per week) or genetically deficient (Ldlr
Abstract Background Trimetazidine (TMZ) has shown anti-ischemic and anti-anginal effects by shifting the production of ATP from free fatty acid to glucose oxidation. Few clinical studies have looked at effectiveness tolerability a new presentation TMZ (80mg once daily) in real-world practice. Purpose The V-GOOD study was conducted routine practice evaluate effect adding 80mg OD treat patients with angina or equivalents despite treatment background therapies. Methods This multicenter,...
Abstract Breast cancer (BC) is the main cause of cancer-related death for women worldwide. While incidence disease still higher in high income countries, lower and middle countries have a proportionally mortality burden account almost half deaths due to globally. In Brazil, BC most common women, with rates that equate those US. has also been increasing steadily are diagnosed late stage greatly lowering their chances survival. Data suggests Black Brown suffer from excess even when extent...