A5074929020- Hormonal and reproductive studies
- Estrogen and related hormone effects
- Stress Responses and Cortisol
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Pharmacology and Obesity Treatment
- Adipose Tissue and Metabolism
- Muscle metabolism and nutrition
- Lipoproteins and Cardiovascular Health
- Hypothalamic control of reproductive hormones
- Regulation of Appetite and Obesity
- Hormonal Regulation and Hypertension
- Adipokines, Inflammation, and Metabolic Diseases
- Retinoids in leukemia and cellular processes
- Clusterin in disease pathology
- Tryptophan and brain disorders
- Diabetes Management and Research
- Pharmacological Effects and Assays
- Neuroendocrine regulation and behavior
- Diabetes Treatment and Management
- Menopause: Health Impacts and Treatments
- Antioxidant Activity and Oxidative Stress
- Prostate Cancer Treatment and Research
- Cholesterol and Lipid Metabolism
- Alzheimer's disease research and treatments
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
University of Washington
2016-2025
Seattle University
2012-2020
Center for Human Reproduction
2018
Theodore Roosevelt High School
2011
Yale University
2006
Comprehensive Clinical Research
2001
Restraint stress has been shown to elicit numerous effects on hippocampal function and neuronal morphology, as well induce dendritic remodeling in the prefrontal cortex (PFC). However, of acute restraint PFC cognitive have not investigated, despite substantial evidence that malfunctions many stress-related disorders.The present study examined both male rats cycling female either proestrus (high estrogen) or estrus (low phase cycle. Animals were restrained for 60 120 minutes then tested...
Abstract Background Retinol binding protein 4 (RBP4) is the plasma carrier of retinol that complexes with transthyretin (TTR). RBP4 a potential biomarker cardiometabolic disease. However, quantitation has relied on immunoassays and western blots without concurrent measurement TTR. A liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for simultaneous absolute serum TTR needed to advance understanding as biomarkers. Methods Surrogate peptides reproducible, linear LC-MS/MS...
In men with prostate cancer, androgen deprivation reduces insulin sensitivity; however, the relative roles played by testosterone and estradiol are unknown. To investigate respective effects of these hormones on sensitivity in men, we employed a model experimental hypogonadism or without hormone replacement.Placebo-controlled, randomized trial.Twenty-two healthy male volunteers, 18-55 years old.Following screening, subjects received gonadotrophin-releasing antagonist acyline plus one...
Testosterone prescriptions have risen steadily and sharply in the USA despite a lack of clear understanding relationship between androgens cardiovascular disease. In men with increasing age, testosterone levels decline disease risk goes up. Ties hypogonadism are suggested by observational data, yet therapy replacement has not been shown to mitigate that risk. To contrary, recent literature raised concern for increased certain groups receiving therapy. this article, we review current an...
THE HEMOGLOBIN A1C (HBA1C) ASSAY WAS FIRST USED more than 30 years ago as a marker of diabetes control. Despite its availability for 2 decades, HbA1c testing did not assume central role in care until the publication major clinical trials. The Diabetes Control and Complications Trial (DCCT) UK Prospective Study (UKPDS) demonstrated that level strongly predicts risk microvascular complications associated with type 1 diabetes, respectively. Largely consequent to these findings, has become...
The effects of androgens on cardiovascular disease (CVD) risk in men remain unclear. To better characterize the relationship between and HDL, we investigated testosterone replacement HDL protein composition serum HDL-mediated cholesterol efflux hypogonadal men. Twenty-three older (ages 51-83, baseline < 280 ng/dl) were administered therapy (1% transdermal gel) with or without 5α-reductase inhibitor dutasteride. At after three months treatment, determined fasting lipid concentrations,...
Objective This study aimed to determine whether a relationship was evident between gliosis in the mediobasal hypothalamus (MBH) and plasma testosterone concentrations men. Methods A total of 41 adult men (aged 18‐50 years) from 23 twin pairs underwent fasting morning blood draw brain magnetic resonance imaging. T2 relaxation time used quantify MBH control areas putamen amygdala. Plasma 17β‐estradiol were measured by liquid chromatography‐tandem mass spectrometry. Body composition including...
Concern exists that T replacement therapy (TRT) might increase the risk of prostate disease. There are limited data regarding impact TRT on androgen concentrations.Determine dose-dependent effects exogenous administration intraprostatic concentrations.Twelve-week, double-blinded, randomized, placebo-controlled trial.Academic medical center.Sixty-two healthy eugonadal men, aged 25-55 years.Subjects were randomly assigned to receive injections acyline, a GnRH antagonist (used achieve...
T deprivation increases risk of insulin resistance in men, but whether this is independent changes body composition unknown. Further, the metabolic roles and its metabolite estradiol have not been clearly defined men.This study sought to establish effects selective sex steroid withdrawal on sensitivity healthy was a double-blinded, placebo-controlled, randomized trial at an academic medical center 56 19-55 years age.Subjects received GnRH antagonist acyline plus one following: placebo gel...
Objective: Expression of the extrahepatic acute-phase protein Saa3 (serum amyloid A3) increases in response to acute and chronic inflammatory stimuli is elevated adipose tissue macrophages obese mice. A recent report suggested that proatherogenic male ApoE −/− Because our previous observation female but not Saa3-deficient mice are protected from obesity, inflammation, hyperlipidemia, we sought determine whether differentially modulates atherosclerosis both sexes. Approach Results: To promote...
The recognition of altered immune system function in many chronic disease states has proven to be a pivotal advance biomedical research over the past decade. For metabolic and mood disorders, this activity been characterized as inflammation, with attendant assumption that response is aberrant. However, accumulating evidence challenges suggests may mounting adaptive responses stressors. Further, inordinate complexity renders simplistic, binary model incapable capturing critical mechanistic...
Androgen deficiency in men increases body fat, but the mechanisms by which testosterone suppresses fat deposition have not been elucidated fully. Adipose tissue macrophages express androgen receptor (AR) and regulate adipose remodeling. Thus, signaling could alter paracrine function of these cells thereby contribute to metabolic effects androgens men. A phenotyping study was performed determine whether loss AR hematopoietic results greater accumulation male mice. C57BL/6J mice (ages 12-14...