A5101764209- Peroxisome Proliferator-Activated Receptors
- Adipokines, Inflammation, and Metabolic Diseases
- Immune cells in cancer
- Cell Adhesion Molecules Research
- Cholesterol and Lipid Metabolism
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Atherosclerosis and Cardiovascular Diseases
- Atrial Fibrillation Management and Outcomes
- Lipid metabolism and disorders
- Viral Infections and Immunology Research
- Phagocytosis and Immune Regulation
- Diabetes Treatment and Management
- Cytokine Signaling Pathways and Interactions
- Cytomegalovirus and herpesvirus research
- HER2/EGFR in Cancer Research
- Intracranial Aneurysms: Treatment and Complications
- Liver Disease Diagnosis and Treatment
- Immune Response and Inflammation
- Lipoproteins and Cardiovascular Health
- Curcumin's Biomedical Applications
- Pancreatitis Pathology and Treatment
- Viral gastroenteritis research and epidemiology
- Advanced Glycation End Products research
- Ovarian function and disorders
- Plant Reproductive Biology
University of Washington
2011-2024
VA Greater Los Angeles Healthcare System
2024
UCLA Health
2024
First Hospital of Xi'an
2023
Xian Central Hospital
2023
Second Hospital of Anhui Medical University
2023
Anhui Medical University
2023
Xi'an Jiaotong University
2022
Diabetes Foundation
2021
Seattle University
2018
Significance Tumor-associated macrophages (TAMs) are cells of our innate immune system that have been associated with poor prognosis in many types cancers. When polarized toward the anti-inflammatory state, TAMs promote evasion and angiogenesis, thereby driving tumor growth. Using a peptide library selection strategy, we identified sequence, called M2pep, preferentially binds to murine macrophages. We then used M2pep carry proapoptotic by i.v. delivery demonstrated selective reduction...
Abstract Osteopontin (OPN) is highly expressed by macrophages and plays a key role in the pathology of several chronic inflammatory diseases including atherosclerosis foreign body reaction. However, molecular mechanism behind OPN regulation macrophage functions not well understood. secreted molecule interacts with integrins via two domains: RGD sequence binding to α v ‐containing integrins, SLAYGLR 4 β 1 , 7 9 integrins. Here we determined survival, chemotaxis, activation state. For survival...
Rationale: Apoptotic cell phagocytosis (efferocytosis) is mediated by specific receptors and essential for resolution of inflammation. In chronic inflammation, apoptotic clearance dysfunctional soluble levels several are elevated. Reports have identified proteolytic cleavage as a mechanism capable releasing receptors, but the functional implications their proteolysis unclear. Objective: To test hypothesis that ADAM17-mediated limits efferocytosis in vivo. Methods Results: vivo comparison...
Inflammatory activation of myeloid cells is accompanied by increased glycolysis, which required for the surge in cytokine production. Although vitro studies suggest that macrophage glucose metabolism sufficient induction, proinflammatory effects cell flux vivo and impact on atherosclerosis, a major complication diabetes, are unknown. We therefore tested hypothesis uptake stimulates production atherosclerosis. Overexpression transporter GLUT1 caused glycolysis through pentose phosphate...
Systemic inflammatory stimuli cause anorexia and weight loss by disrupting the physiological regulation of energy balance. Mice lacking MyD88, an intracellular mediator signal transduction activated Toll-like receptor 4 or IL-1beta receptors, are resistant to induced bacterial endotoxin lipopolysaccharide (LPS), despite a significant circulating cytokine response. Thus, we hypothesized that induction peripheral response is insufficient LPS-induced when MyD88 signaling in central nervous...
Precise channel estimation is fundamental to ensuring the reliability, response time, and data accuracy in load management systems, particularly complex power system environments where communication issues arise from multipath fading propagation interference. This paper presents an innovative method specifically designed for systems. The proposed employs a Channel Generative Adversarial Network (Channel GAN) architecture, combining Super-Resolution (SRGAN) Denoising (DnGAN) techniques....
Triggering receptor expressed on myeloid cells 2 (TREM2), a transmembrane, lipid-sensing protein by Kupffer cells, is thought to play role in metabolic dysfunction-associated steatotic liver disease (MASLD) and steatohepatitis (MASH). Plasma levels of the TREM2 cleavage product, soluble (sTREM2), are strongly associated with MASLD severity. We investigated MASH pathogenesis whether sTREM2 acts both as biomarker mediator MASH. Adult C57BL/6J mice were assigned normal, high-fat (HF), or...
Macrophages are prominent cells in acute and chronic inflammatory diseases. Recent studies highlight a role for macrophage proliferation post-monocyte recruitment under conditions. Using an peritonitis model, we identify significant defect mice lacking the leukocyte transmembrane protease ADAM17. The is associated with decreased levels of colony-stimulating factor 1 (CSF-1) peritoneum rescued by intraperitoneal injection CSF-1. Cell surface CSF-1 (csCSF-1) one substrates We demonstrate that...
Objective: Expression of the extrahepatic acute-phase protein Saa3 (serum amyloid A3) increases in response to acute and chronic inflammatory stimuli is elevated adipose tissue macrophages obese mice. A recent report suggested that proatherogenic male ApoE −/− Because our previous observation female but not Saa3-deficient mice are protected from obesity, inflammation, hyperlipidemia, we sought determine whether differentially modulates atherosclerosis both sexes. Approach Results: To promote...
Pathogenetic mechanisms of the progression NAFL to advanced NASH coupled with potential noninvasive biomarkers and novel therapeutic targets are active areas investigation. The recent finding that increased plasma levels a protein shed by myeloid cells -soluble Triggering Receptor Expressed on Myeloid 2 (sTREM2) -may be biomarker for has received much interest. We aimed test sTREM2 as human investigate role in pathogenesis NASH.
A new, large kindred with hypobetalipoproteinemia and a previously undescribed truncated form of apolipoprotein B (apoB) has been identified. The asymptomatic, Caucasian male proband (CK, aged 37 years) total plasma cholesterol, triglyceride, low density lipoprotein-(LDL) high lipoprotein- (HDL) apoB concentrations 108, 131, 32, 50, 16 mg/dl, respectively. Plasma samples 11 family members spanning three generations, which had less than 5th percentile LDL-cholesterol, contained bands detected...
Nonresolving inflammation is one of the consistent features tumor microenvironment in intestine and plays a critical role initiation development colon cancer. Here we reported inhibitory effects GEN-27, new derivative genistein, on inflammation-related cancer cell proliferation delineated mechanism its action. The results indicated that GEN-27 inhibited human HCT116 cells stimulated by culture supernatants LPS-induced monocytes THP-1 significantly decreased secretion proinflammatory...
Human enterovirus B106 (EV-B106) is a recently identified member of species B. In this study, we report the complete genomic characterization an EV-B106 strain (148/YN/CHN/12) isolated from acute flaccid paralysis patient in Yunnan Province, China. The new had 79.2-81.3% nucleotide and 89.1-94.8% amino acid similarity VP1 region with other two strains Bolivia Pakistan. When compared EV serotypes, it highest (73.3%) EV-B77 prototype CF496-99. However, when aligned all sequences available...
This study analyzed both the influencing factors of malnutrition in patients with gastric cancer and established a multi-dimensional risk model to predict postoperative three months after surgery.The clinical data hospitalized for first time receiving laparoscopic surgery general department our hospital were retrospectively through information system divided into training set validation ratio 7:3. Nutritional status was assessed using Patient Generated Subjective Global Assessment scale...