A5102817092- Peroxisome Proliferator-Activated Receptors
- Cholesterol and Lipid Metabolism
- Cancer, Lipids, and Metabolism
- Lipoproteins and Cardiovascular Health
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Drug Transport and Resistance Mechanisms
- Adipokines, Inflammation, and Metabolic Diseases
- Enzyme Production and Characterization
- RNA and protein synthesis mechanisms
- Lipid metabolism and disorders
- Molecular Biology Techniques and Applications
- Adipose Tissue and Metabolism
- RNA Research and Splicing
- Bacteriophages and microbial interactions
- Bacterial Genetics and Biotechnology
- RNA modifications and cancer
- Phytase and its Applications
- Atherosclerosis and Cardiovascular Diseases
- Estrogen and related hormone effects
- Enzyme Catalysis and Immobilization
- Metabolism, Diabetes, and Cancer
- Hormonal Regulation and Hypertension
- Diet and metabolism studies
- Alzheimer's disease research and treatments
- Diabetes Treatment and Management
Northeastern University
2023
Drexel University
2013-2018
Creative Commons
2018
Bristol-Myers Squibb (United States)
2016
Piramal (India)
2008-2015
Esperion Therapeutics (United States)
2010-2012
Washington University in St. Louis
1994-2003
Wadia Institute of Himalayan Geology
1992
Institute of Minerals and Materials Technology
1991
North East Institute of Science and Technology
1986-1991
The antiatherogenic property of estrogens is mediated via at least two mechanisms: first by affecting plasma lipoprotein profiles, and second the components vessel wall. Raising apolipoprotein E (apoE) in mice protects them against diet-induced atherosclerosis (Shimano, H., Yamada, N., Katsuki, M., Gotoda, T., Harada, K., Murase, Fukuzawa, C., Takaku, F., Yazaka, Y. (1992) Proc. Natl. Acad. Sci. U. S. A. 89, 1750-1754). It possible that estrogen may be part increasing apoE levels. Therefore,...
Bacillus stearothermophilus grew better on complex and semisynthetic medium than synthetic supplemented with amino acids. Amylase production the containing beef extract or corn steep liquor was higher peptone (0.4%). The medium, however, did not provide a good yield of extracellular amylase. Among carbohydrates which favored amylase are, in order starch > dextrin glycogen cellobiose maltohexaose-maltopeptaose maltotetraose maltotriose. monosaccharides repressed enzyme production, whereas...
Rats and mice are frequently used in studies of the regulation lipoprotein metabolism. Although species closely related, they differ dramatically responses their lipoproteins to estrogen administration. In rats, estrogens produce profound decreases levels all plasma this is attributed largely estrogen‐induced increases hepatic low‐density receptor (LDL‐receptor) activity. Estrogens affect mouse a much lesser extent. Therefore, one our aims was compare LDL‐receptor gene expression rats at...
Summary Cells overexpressing the RNA‐processing enzymes RNase III, E and P were fractionated into membrane cytoplasm. The associated with fraction. was further separated to inner outer three found in By assaying for these enzymatic activities we showed that even a normal wild‐type strain of Escherichia coli fractionate primarily membrane. RNA part is cytosolic fraction cells this RNA, while overexpressed protein sediments fraction; suggests anchors catalytic moiety enzyme larger entity....
To induce dietary atherosclerosis in mice, high-fat/high-cholesterol (HF) diets are frequently supplemented with cholic acid (CA). This diet produces low plasma levels of high-density lipoprotein (HDL) and high low-density (LDL). However, HF without any added CA, which more closely resemble human diets, increase both HDL LDL, suggesting that CA may be responsible for the lowering HDL. Our aim was to examine potential mechanism Nontransgenic (NTg) C57BL mice apoA-I-transgenic (apoAI-Tg)...
An 1,3-oxybenzylglycine based compound 2 (BMS-687453) was discovered to be a potent and selective peroxisome proliferator activated receptor (PPAR) alpha agonist, with an EC(50) of 10 nM for human PPARalpha approximately 410-fold selectivity vs PPARgamma in PPAR-GAL4 transactivation assays. Similar potencies were also observed the full length co-transfection Compound has negligible cross-reactivity against panel nuclear hormone receptors including PPARdelta. demonstrated excellent...
A large body of evidence suggests that atherosclerosis is an inflammatory disease, in which cytokines and growth factors play a major role disease progression. The methanolic extracts Sphaeranthus indicus as well its active ingredient, 7-hydroxy frullanoide (7-HF), are shown to suppress LPS-induced cytokine production from mononuclear cells, inhibit the expression VCAM1, ICAM1 E-selectin by TNF-α- stimulated HUVECs concentration-dependent manner. We tested hypothesis inhibition adhesion...
Our in vivo studies mice have shown that LDL- receptor gene expression is regulated differently both liver and intestine by dietary cholesterol saturated fat. While serves to regulate at transcriptional levels, fatty acids do not. To study the mechanism of regulation LDL-receptor fat cellular level, where any secondary effects long-term feeding are minimized, we used cultured hepa- toma colon carcinoma cells, He G2 Caco2. LDL-re- ceptor activity was determined 1y51-labeled LDL binding...
The first generation peroxisome proliferator-activated receptor (PPAR) α agonist gemfibrozil reduces the risk of major cardiovascular events; therefore, more potent PPARα agonists for treatment diseases have been actively sought. We describe two novel, oxybenzylglycine PPARα-selective agonists, BMS-687453 [<i>N</i>-[[3-[[2-(4-chlorophenyl)-5-methyl-4-oxazolyl]methoxy]phenyl]methyl]-<i>N</i>-(methoxycarbonyl)-glycine] and BMS-711939...