A5049855356- Nitric Oxide and Endothelin Effects
- Receptor Mechanisms and Signaling
- Ultrasound and Hyperthermia Applications
- Cholesterol and Lipid Metabolism
- Cancer, Hypoxia, and Metabolism
- Eicosanoids and Hypertension Pharmacology
- Diet and metabolism studies
- Fatty Acid Research and Health
- Gallbladder and Bile Duct Disorders
- Gastroesophageal reflux and treatments
- Gastrointestinal motility and disorders
- Drug Transport and Resistance Mechanisms
- Advanced MRI Techniques and Applications
- Ultrasound Imaging and Elastography
- Pneumonia and Respiratory Infections
- Pancreatitis Pathology and Treatment
- Pancreatic and Hepatic Oncology Research
- Spectroscopy Techniques in Biomedical and Chemical Research
- Epigenetics and DNA Methylation
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Dermatological and Skeletal Disorders
- Lipid metabolism and disorders
- Advanced Radiotherapy Techniques
- Photoacoustic and Ultrasonic Imaging
- Inflammatory mediators and NSAID effects
Atrium Medical Cente
2025
Swedish Medical Center
2024
Drexel University
2020-2022
Aerpio Pharmaceuticals (United States)
2018-2020
University of Pennsylvania
2020
Boston Scientific (United States)
2020
Medica (United States)
2015
Development Fund
2015
University of Minnesota Medical Center
2011-2015
Southampton General Hospital
1983-2005
Because so much medical and media attention has been drawn to the alleged benefits of dehydroepiandrosterone (DHEA) its sulfate ester (DHEAS), it is important evaluate effects replacement therapy objectively using double blind, cross-over, randomized research methodology. In this 9-month study, healthy older men (n = 39) received dose DHEA. Lean body mass, blood hematology, chemistry endocrine values, as well urological psychological data were measured. Data showed some mild temporary, but...
PURPOSE: The purpose of this study was to measure the daily prevalence adhesive product use and related skin injuries in adult patients a non–intensive care unit setting. DESIGN: Prospective, descriptive study. SUBJECTS AND SETTING: sample consisted cared for on 2 inpatient units university-based acute facility Midwestern United States. One 30-bed medical/surgical second 35-bed cardiac/telemetry unit. Their median age 58 years; average proportion males females 56% 42%, respectively. METHODS:...
Abstract Background Methicillin resistant Staphylococcus aureus (MRSA) colonization often precedes invasive infection; decolonization may prevent morbidity and mortality. MRSA surveillance protocols vary widely; at Brenner Children's Hospital (BCH), infants in the neonatal intensive care unit (NICU) undergo repeat testing after decolonization, allowing assessment of colonization/recolonization events their relationship to infection. Methods PCR combined nasal/umbilical swabs from BCH NICU...
A study was performed to determine the effect of bile acid perfusion on motility in sigmoid colon patients with irritable syndrome compared normal subjects. Deoxycholic (15 mM) statistically significantly increased subjects (control 25.0 +/- 6.4%, 71.4 7.2%, P < 0.05) but neither chenodeoxycholic nor cholic had any apparent effect. In syndrome, however, deoxycholic at 5 mM concentration 29.8 4.2%, during 57.4 6.5%, as well 15 19.4 5.7+, 57.8 9.6%, rectosigmoid motility. Patients a high...
Abstract Bile acids are thought to be involved in both the aetiology and development of colorectal cancer. In this study existence specific bile acid receptor proteins has been postulated. A assay which labelling with 14C-deoxycholic was performed as well autoradiography using 3H-deoxycholic acid. an initial resected cancer adjacent histologically normal mucosa from 39 patients were studied, samples gastric mucosa, cancers benign tumours. Specific receptors deoxycholic detected 12 (30·8 per...
The first generation peroxisome proliferator-activated receptor (PPAR) α agonist gemfibrozil reduces the risk of major cardiovascular events; therefore, more potent PPARα agonists for treatment diseases have been actively sought. We describe two novel, oxybenzylglycine PPARα-selective agonists, BMS-687453 [<i>N</i>-[[3-[[2-(4-chlorophenyl)-5-methyl-4-oxazolyl]methoxy]phenyl]methyl]-<i>N</i>-(methoxycarbonyl)-glycine] and BMS-711939...
Historically diet and arthritis have been cause/effect associated but the idea is controversial with little evidence that specific components are effective treatment. This controlled, double-blinded, crossover study reports effect of folate cobalamin supplements in 26 humans diagnosed for an average 5.7 years idiopathic osteoarthritis hands who had medicated by prescribed nonsteroidal anti-inflammatory drugs (NSAID).Subjects entered after a 10-day washout period from use all anti-arthritis...
The effect of different concentrations sodium cholate, chenodeoxycholate and deoxycholate on colonic myoelectrical activity was studied in 4 dogs. There no statistically significant difference percentage motility, motility index, basal pressure or mean slow wave frequency with either cholic chenodeoxycholic acid (5--15 mM). Deoxycholic (15 mM), however, caused a marked increase (median control value 4.1, range 0--23; after installation, median 27--0, 20.6--45.0, P less than 0.001). This...
Background Oritavancin is an investigational lipoglycopeptide antibiotic under clinical development for the treatment of gram-positive bacterial infections. The impact hemodialysis on plasma concentrations oritavancin unknown and may be important in making dosage adjustments such patients. present study sought to determine clearance from human blood by various commercially available dialyzers vitro model. Methods Three types each low-flux (Dicea 130, F6, Polyflux 14L) high-flux (Revaclear,...
Bioscientists, physicians and nutritionists are newly interested in the homocysteine-folate-cobalamin triad, part because homocysteine may be important both atherogenesis thrombogenesis. Homocysteine imbalance an early marker for cobalamin disorders is a cofactor remethylation of to methionine.In 139 men 32 women similar mean age 65 years, we measured markers which have been cited as risk atherosclerosis: serum homocysteine, folate, total cobalamin, holotranscobalamin I II, (TCI TCII),...
Continued development around our ETA-selective endothelin (ET) antagonist 1 (CI-1020) has led to the synthesis of analogues with improved aqueous solubility profiles. Poor characteristics displayed by required a complex buffered formulation in order conduct iv studies. To overcome use specific formulations for preclinical studies on additional drug candidates, were desired. Several synthesized substitution patterns that allowed formation either acid or base addition salts. These derivatives...
A 6-month crossover diet plan was employed to study the effects on human serum lipids of adding margarine or butter otherwise self-selected diets that included two eggs daily. Two groups subjects were studied: 51 free-living normocholesterolemic and 20 hypercholesterolemic (greater than 240 mg dl). Four-day records in each interval showed ate about 16% total dietary fat as either margarine. Blood samples taken every 6 weeks variable mean cholesterol (SCHOL), high-density-lipoprotein (HDL-C),...
The effect of bile acid perfusion on colonic motor function in vitro has been studied. It was found that and carbachol had no the frequency or incidence slow wave activity. However, secondary deoxycholic (15 mmol/l) shown to cause a statistically significant increase percentage motility isolated colon (control 24.2 + 5.5%, 64.9 7.3%, p < 0.01). magnitude this similar increased recorded during (2.5 μg/cm3) infusion. Chenodeoxycholic cholic acids did not vitro.
Summary Faecal bile acid excretion and sigmoid myoelectrical activity were measured on three separate occasions over a 12-month period in 21 patients with diverticular disease the results compared those of 17 age-matched normal subjects. Statistically significantly lower faecal concentrations both deoxycholic lithocholic found (96·7 ± 11·3 mg/100 g, 59·6 6·0 g respectively) when subjects (219 32·0 117·6 14·6 respectively P &lt; 0·001). These values persisted throughout study. Patients to...
We have described the pharmacologic profiles of endothelin B receptors in human endothelial cells and vascular nonvascular smooth-muscle cells. First, by amplifying receptor numbers through use phosphoramidon intact cell-binding techniques, we demonstrated presence these umbilical vein (100% receptors), aortic (22% B, 78% A bronchial (55% 45% receptors) using [125I]-endothelin-1 radioligand binding. The typical binding were established competition curve analysis with endothelin-1,...
Hemobilia is an uncommonly recognized entity and postoperative acute acalculous cholecystitis uncommon clinical entity. Hemorrhagic causing pancreatitis has apparently not been reported before. We report the case of a multiple trauma victim who, several weeks after his initial injuries, developed secondary to hemobilia caused by hemorrhagic cholecystitis.