A5101896002- Inflammasome and immune disorders
- Immune Response and Inflammation
- Phagocytosis and Immune Regulation
- Immune Cell Function and Interaction
- Hemodynamic Monitoring and Therapy
- Cell death mechanisms and regulation
- Heme Oxygenase-1 and Carbon Monoxide
- Cancer Immunotherapy and Biomarkers
- Intracerebral and Subarachnoid Hemorrhage Research
- Aortic aneurysm repair treatments
- Pharmacological Effects of Natural Compounds
- Systemic Lupus Erythematosus Research
- Signaling Pathways in Disease
- Poxvirus research and outbreaks
- Atherosclerosis and Cardiovascular Diseases
- Pulmonary Hypertension Research and Treatments
- Parkinson's Disease and Spinal Disorders
- Neurological Disease Mechanisms and Treatments
- Cardiovascular Function and Risk Factors
- Alcohol Consumption and Health Effects
- Chronic Kidney Disease and Diabetes
- Viral gastroenteritis research and epidemiology
- Neural Networks and Applications
- School Health and Nursing Education
- Traditional Chinese Medicine Analysis
China Animal Disease Control Center
2025
Yunnan Center for Disease Control And Prevention
2024
Capital Medical University
2008-2023
National Clinical Research Center for Digestive Diseases
2022
University Medical Center Groningen
2015-2020
University of Groningen
2015-2020
Shanxi Medical University
2015-2020
First Affiliated Hospital of Bengbu Medical College
2019
University of Southern California
2017
Second Affiliated Hospital of Xi'an Jiaotong University
2016
Alcoholic hepatitis (AH) continues to be a disease with high mortality and no efficacious medical treatment. Although severe AH is presented as acute on chronic liver failure, what underlies this transition from alcoholic steatohepatitis (ASH) largely unknown. To address question, unbiased RNA sequencing proteomic analyses were performed livers of the recently developed mouse model, which exhibits shift ASH upon weekly alcohol binge, these results are compared gene expression profiling data...
While current Vision Transformer (ViT) adapter methods have shown promising accuracy, their inference speed is implicitly hindered by inefficient memory access operations, e.g., standard normalization and frequent reshaping. In this work, we propose META, a simple fast ViT that can improve the model's efficiency decrease time consumption reducing operations. Our method features memory-efficient block enables common sharing of layer between self-attention feed-forward network layers, thereby...
Porcine epidemic diarrhea virus (PEDV) is a highly contagious pathogen responsible for devastating enteric disease and lethal watery diarrhea, leading to significant economic losses in the global swine industry. Understanding epidemiology genetic diversity of PEDV over past decade crucial effective prevention treatment porcine diarrhea. In this study, 1851 fecal samples were collected from pigs exhibiting symptoms across 11 cities Yunnan Province between 2013 2022. The prevalence PEDV, along...
Abstract Sepsis is a systemic inflammatory response to infections associated with organ failure that the most frequent cause of death in hospitalized patients. Exaggerated endothelial activation, altered blood flow, vascular leakage, and other disturbances synergistically contribute sepsis-induced failure. The underlying signaling events proinflammatory activation are not well understood, yet they likely consist molecular pathways act an endothelium-specific manner. We found LPS, critical...
Sepsis is a severe systemic inflammatory response to infection. Endothelial activation and dysfunction play critical role in the pathophysiology of sepsis represent an important therapeutic target reduce mortality. Interferon regulatory factor 1 (IRF-1) was recently identified as downstream TNF-α-mediated signal transduction endothelial cells. The aim this study explore importance IRF-1 regulator lipopolysaccharide (LPS)-induced proinflammatory activation. We found that renal upregulated by...
Objective: To investigate the consequences of histone deacetylase inhibition by inhibitor valproic acid and IκB kinase/nuclear factor-κB signaling blockade kinase BAY11-7082 on (microvascular) endothelial cell behavior in vitro as well mice subjected to hemorrhagic shock/resuscitation vivo. Design: Prospective, randomized laboratory investigation using an established mouse model shock. Setting: Research at university teaching hospital. Subjects: Endothelial cells C57BL/6 male mice....
ABSTRACT Hemorrhagic shock (HS) is associated with low blood pressure due to excessive loss of circulating and causes both macrocirculatory microcirculatory dysfunction. Fluid resuscitation after HS used in the clinic restore tissue perfusion. The persistent damage caused by and/or can result multiple organ damage, kidney being one involved organs. microvasculature consists different segments that possess a remarkable heterogeneity functional properties. aim this study was investigate...
Sepsis is a life-threatening condition often leading to multiple organ failure for which currently no pharmacological treatment available. Endothelial cells (EC) are among the first respond pathogens and inflammatory mediators in sepsis might be sentinel target prevent occurrence of failure. Lipopolysaccharide (LPS) Gram-negative bacterial component that induces endothelial expression adhesion molecules, cytokines, chemokines. This regulated by network kinases, result vivo enables leukocytes...
Atherosclerosis is widely recognized as a complex inflammatory disease involving pathogenic immune response of T cells and antigen-presenting (APCs) such dendritic (DCs) macrophages. Accumulating evidence has revealed that mature DCs play critical roles in the differentiation effector into CD4+ cells, which effectively participate onset acute coronary syndrome (ACS). IFN regulatory factor (IRF)-1 been shown to be involved various processes. The role IRF-1 pathogenesis ACS not investigated.We...
Abstract Background Lumpy skin disease (LSD) is caused by the lumpy virus (LSDV) and has emerged as a significant threat to cattle water buffalo industries in China. Investigating epidemiological characteristics of LSDV will be beneficial control prevention this disease. In study, Taqman-Probe-Based real-time PCR (qPCR) assay was developed for detecting nucleotides, 2495 tissue or blood samples were collected from Yunnan province tested using established qPCR assay. The GPCR p32 genes...
Right ventricular function plays an important role in the hemodynamic derangement during off-pump coronary artery bypass (OPCAB) surgery. Pressure-volume loops have been shown to provide load-independent information of cardiac function. Therefore, aim this study was investigate feasibility construction right pressure-volume with pressure and volume data measured by a volumetric pulmonary catheter (PAC) evaluate systolic diastolic end-systolic elastance (E(ES)) end-diastolic stiffness (E(ED))...
Objective To evaluate the feasibility of using stroke volume variation(SVV)as left ventricular preload to draw cardiac function curve. Methods Twenty-seven patients both sexes, aged 18-64 yr, with body mass index 18-30 kg/m2, American Society Anesthesiologists physical status Ⅱ(New York Heart Association Ⅱ), abnormal function, scheduled for elective off-pany coronary artery byp grafting, were enrolled in this study.Twenty-five patients, Ⅰ(New Ⅰ), normal non-cardiac surgery, also...
Numerous studies and clinical trials have shown that immune checkpoint inhibitors can effectively prevent tumor growth metastasis in esophageal squamous cell carcinoma (ESCC) patients. In this study, we aimed to evaluate the anti-tumor effects of PD-1 prevention treatment patients with early stages ESCC as well high-grade intraepithelial neoplasia (HGIN). We first established an model using C57BL/6J mice treated chemical carcinogen 4- NQO observed lesions at different time points. Second,...
Objective To investigate the value of 18F-fluorodeoxyglucose (FDG) PET/CT imaging and cardiac MRI (CMR) in diagnosis radiation-induced heart disease (RIHD) Beagle models. Methods Twenty-four normal male dogs (1-year old) were randomly divided into control group irradiated groups (3-month, 6-month 12-month after radiation). The left anterior myocardium was locally with a single dose 20 Gy X-ray. Cardiac 18F-FDG CMR performed on all dogs, mean standardized uptake (SUVmean) area lesions...