A5085243153- Genetic factors in colorectal cancer
- Cancer Immunotherapy and Biomarkers
- Cancer-related gene regulation
- Cancer Cells and Metastasis
- Methane Hydrates and Related Phenomena
- Pancreatic and Hepatic Oncology Research
- Lung Cancer Treatments and Mutations
- Cancer Genomics and Diagnostics
- Colorectal Cancer Treatments and Studies
- Sports, Gender, and Society
- Gastric Cancer Management and Outcomes
- Sport Psychology and Performance
- Metal Extraction and Bioleaching
- Ferroptosis and cancer prognosis
- CO2 Sequestration and Geologic Interactions
- Hydrocarbon exploration and reservoir analysis
- Physical Education and Pedagogy
- Immune Cell Function and Interaction
- Sport and Mega-Event Impacts
- Extraction and Separation Processes
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Lung Cancer Research Studies
- Immune cells in cancer
- Traditional Chinese Medicine Studies
- Renal cell carcinoma treatment
Capital Medical University
2015-2025
Beijing Chao-Yang Hospital
2015-2024
Beijing Sport University
2021-2024
Central South University
2019-2024
State Key Laboratory of Hydrology-Water Resources and Hydraulic Engineering
2021-2024
Southern University of Science and Technology
2022-2024
Chang'an University
2024
Jilin Academy of Agricultural Sciences
2023-2024
Renmin Hospital of Wuhan University
2024
Anhui University of Traditional Chinese Medicine
2023-2024
Background: This study evaluated the CGRP receptor antagonist MK-3207 for acute treatment of migraine. Methods: Multicenter, double-blind, randomized, placebo-controlled, parallel-group, two-stage adaptive with two interim efficacy analyses to facilitate optimal dose selection. Migraine patients were initially randomized 2.5, 5, 10, 20, 50 and 100 mg or placebo treat a moderate/severe One more doses be discontinued based on first analysis lower higher could added second analysis. The primary...
More than 80% of intestinal neoplasia is associated with the adenomatous polyposis coli (APC) mutation. Doublecortin-like kinase 1 (Dclk1), a protein, overexpressed in colorectal cancer and specifically marks tumor stem cells (TSCs) that self-renew increased progeny Apc Min/+ mice. However, role Dclk1 expression its contribution to regulating pro-survival signaling for progression mutant poorly understood.We analyzed DCLK1 gene datasets 329 specimens from TCGA Colon Adenocarcinoma Cancer...
Aim The aim of this article is to evaluate the safety and efficacy perimenstrual telcagepant, a CGRP receptor antagonist, for headache prophylaxis. Methods We conducted randomized, double-blind, placebo-controlled, six-month trial in women with migraine ≥3 months who experienced headaches. Women were randomized telcagepant 140 mg or placebo (2:1 ratio) seven consecutive days perimenstrually. Safety was assessed by adverse events laboratory tests. primary endpoint mean monthly subset...
Cancer-associated fibroblasts (CAFs) contribute notably to colorectal cancer (CRC) tumorigenesis, stiffness, angiogenesis, immunosuppression and metastasis, could serve as a promising therapeutic target. Our purpose was construct CAF-related prognostic signature for CRC.We performed bioinformatics analysis on single-cell transcriptome data derived from Gene Expression Omnibus (GEO) identified 208 differentially expressed cell markers cluster. Bulk gene expression of CRC obtained The Cancer...
Lung adenocarcinoma is the most common form of lung cancer, accounting for 60% non-small cell cancer (NSCLC) cases in Asian patients. Importantly, nearly half these patients have epithelial growth factor receptor (EGFR) mutations. Though EGFR-tyrosine kinase inhibitors (EGFR-TKIs) are recommended as first-line therapy NSCLC patients, development resistance reduces their efficiency and limits application. As complicated heterogeneous mechanism acquired among individuals, anti-angiogenesis...
Renal cell carcinoma (RCC) is a common and devastating disease characterized by hypoxic microenvironment, epithelial‐mesenchymal transition potent resistance to therapy evidencing the presence of cancer stem cells (CSCs). Various CSC markers have been studied in RCC, but overall there limited data on their role most relatively nonspecific. Doublecortin‐like kinase 1 (DCLK1) validated marker gastrointestinal tract evidence for an equivalent other cancers accumulating. We used bioinformatics,...
Purpose: Collagen type I alpha 2 chain (COL1A2) has been shown to participate in the development of various human malignancies.However, role COL1A2 colorectal cancer (CRC) remains unknown.This study investigated expression pattern primary CRC tissues as well correlation with clinicopathological features and prognosis CRC.The function cell proliferation, migration, invasion possible mechanisms were also examined.Methods: Real-time PCR immunohistochemical analysis performed determine adjacent...
Long non-coding RNAs (lncRNAs) play a key role in the development and metastasis of cancer. However, biological clinical significance lncRNA DNAJC3-AS1 colon cancer is still unknown. In this study, effects on cell proliferation, migration, invasion were evaluated by MTT assay, wound-healing transwell respectively. The relationship between DNAJC3-AS1, miR-214-3p LIVIN was predicted online software confirmed dual-luciferase reporter assay. We found that down-regulation inhibited proliferation...
Carbon storage is an essential approach to mitigating global warming and realizing the negative emissions of greenhouse gases. A practical strategy immobilize CO2 in marine sediments form hydrates. Clay, as one most significant components sediments, has a critical impact on hydrate formation. In this study, montmorillonite was selected clay mineral medium, effects water content, pressure, content were investigated. As increased, transformed from adsorption formation, resulting increase final...
Although oxaliplatin is an effective chemotherapeutic drug commonly used for colorectal cancer (CRC) treatment, resistance usually occurs during the long-term use of it. It urgent to create strategies reduce CRC cells oxaliplatin. Oxaliplatin-resistant (OR-SW480 and OR-HT29) were acquired through exposure was found that OR-SW480 OR-HT29 exhibited obvious lower sensitivity a higher metabolism rate glucose compared their parental SW480 HT29 cells, respectively. However, combination with...
Triple-negative breast cancer (TNBC) exhibits the poorest outcomes among subtypes due to high heterogeneity and a lasting scarcity of effectual treatments. Targeted therapies based on molecular TNBC are critical step toward tailoring treatments improve clinical outcomes. Gastrointestinal stem cell (CSC) marker DCLK1 was reported be highly expressed in cell-rich subtype TNBC. Here, we firstly explored impacts tumor cells as well their immune microenvironment potential therapeutic strategies...
Danshen was able to reduce the risk of patients with coronary heart disease (CHD), but mechanism is still widely unknown. Biochemical indices (lipid profile, markers renal and liver function, homocysteine (Hcy)) are closely associated CHD risk. We aimed investigate whether medicine reduces by improving these biochemical indices. The received 10 pills (27 mg/pill) in Dashen group, while control placebo pills, three times daily. duration follow-up months. serum were measured, including lipid...
There is a lack of research on the social construction gender and sexuality in elite women's boxing psychological implications. Building that theorizes as intersecting identities, this study explored women boxers' (n = 10) identities relation to inclusion marginalization Canadian National Boxing Team. Constructionist thematic analysis identified central theme, "boxing empowering constraining," encompassing multiple meanings gendered related physicality sexualities. These were tied exclusion....