A5115721816- Liver Disease Diagnosis and Treatment
- Estrogen and related hormone effects
- RNA modifications and cancer
- Cancer Genomics and Diagnostics
- Lung Cancer Treatments and Mutations
- Adipose Tissue and Metabolism
- Cancer, Lipids, and Metabolism
- Cancer-related molecular mechanisms research
- Hepatocellular Carcinoma Treatment and Prognosis
- Neurosurgical Procedures and Complications
- DNA and Nucleic Acid Chemistry
- Lipid metabolism and biosynthesis
- Pluripotent Stem Cells Research
- Chromatography in Natural Products
- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
- Ubiquitin and proteasome pathways
- Head and Neck Surgical Oncology
- Inflammatory mediators and NSAID effects
- Circular RNAs in diseases
- Cancer therapeutics and mechanisms
- Mitochondrial Function and Pathology
- Pancreatic and Hepatic Oncology Research
- Cancer, Hypoxia, and Metabolism
- Liver physiology and pathology
Case Western Reserve University
2025
University of Pittsburgh
2024
Jiangxi University of Traditional Chinese Medicine
2024
Sun Yat-sen Memorial Hospital
2015-2021
Sun Yat-sen University
2015-2021
China Medical University
2018-2019
Purpose: Collagen type I alpha 2 chain (COL1A2) has been shown to participate in the development of various human malignancies.However, role COL1A2 colorectal cancer (CRC) remains unknown.This study investigated expression pattern primary CRC tissues as well correlation with clinicopathological features and prognosis CRC.The function cell proliferation, migration, invasion possible mechanisms were also examined.Methods: Real-time PCR immunohistochemical analysis performed determine adjacent...
Targeting the estrogen receptor (ER or ERα) through competitive antagonists, downregulators, synthesis inhibition remains primary therapeutic strategy for luminal breast cancer. We have identified a novel mechanism of ER by targeting critical interface between its DNA-binding domain (DBD) and ligand-binding (LBD). demonstrate that mitoxantrone (MTO), topoisomerase II inhibitor, binds at this previously unexplored DBD-LBD interface. Using comprehensive computational, biophysical, biochemical,...
Background: Soothing the liver (called Shu Gan Jie Yu in Chinese, SGJY) is a significant therapeutic method for breast cancer TCM. In this study, 3 liver-soothing herbs, including Cyperus rotundus L., Citrus medica L. var. sarcodactylis Swingle and Rosa rugosa Thunb. were selected combined to form SGJY herbal combinatory. The Aim of Study: To investigate inhibiting effect on vivo vitro, explore potential mechanisms. Materials Methods: combination was extracted using water. A rat model...
Background and Aims: TM6SF2 rs58542926 (E167K) is related to an increased prevalence of metabolic dysfunction–associated steatotic liver disease. Conflicting mouse study results highlight the need for a human model understand this mutation’s impact. This aims create characterize reliable in vitro mimic effects TM6SF2-E167K mutation future studies. Approach Results: We used gene editing on human-induced pluripotent stem cells from healthy individual with mutation. After hepatocyte-directed...
Lung cancer is the most aggressive cancer, resulting in one-quarter of all cancer-related deaths, and its metastatic spread accounts for >70% these especially metastasis to brain. Metastasis-associated mutations are important biomarkers prediction outcome improvement.In this study, we applied whole-exome sequencing (WES) identify potential metastasis-related 12 paired lung brain samples.We identified 1,702 single nucleotide variants (SNVs) 6,131 mutation events among 1,220 genes....
Objectives The objective was to explore further the surgical treatment of posttraumatic skull base defects with cerebrospinal fluid (CSF) leak and identify most common factors affecting defect CSF retrospectively. Materials Methods This study included 144 patients head trauma having who had been surgically treated at Sun Yat-Sen Memorial Hospital University from 1998 June 2016. There were 113 (78.5%) males 31 (21.5%) females, age ranging 1 78 years mean 26.58 ± 14.95 years. We explored...
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related deaths, and commonly associated with hepatic fibrosis or cirrhosis. This study aims to establish rat model mimicking the progression from liver cirrhosis subsequently HCC using thioacetamide (TAA). We utilized male Lewis rats, treating them intra-peritoneal injections TAA. These rats received bi-weekly either 200 mg/kg TAA saline (as control) over period 34 weeks. The development hepatocarcinogenesis was monitored through...
Currently, Type 1 diabetes (T1D) can be treated through implantation of allogenic islets, which replenish the beta cell population, however this method requires an extensive post-implantation immunosuppressant regimen. Personalized cellular therapy address autologous induced pluripotent stem cells (iPSCs). Cellular therapy, however, encapsulation device for implantation, and so to achieve uniformly with in a clinical setting, bioprinting is required. Bioprinting dependent on having bioink...
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related deaths, and commonly associated with hepatic fibrosis or cirrhosis. This study aims to establish rat model mimicking the progression from liver cirrhosis subsequently HCC using thioacetamide (TAA). We utilized male Lewis rats, treating them intra-peritoneal injections TAA. These rats received bi-weekly either 200 mg/kg TAA saline (as control) over period 34 weeks. The development hepatocarcinogenesis was monitored through...
TM6SF2 rs58542926 (E167K) is associated with an increase in the prevalence of Metabolic Disfunction-Associated Steatotic Liver Disease (MASLD). Despite all investigation related to role this variant lipid metabolism, conflicting results mouse studies underscore importance creating a human model for understanding mechanism. Therefore, aim study generate reliable vitro that mimic effects E167K mutation and can be used future mechanism studies.
Background: Lung cancer is the most aggressive which representing one-quarter of all cancer-related deaths, and metastatic spread accounts for >70% these especially brain metastasis. Metastasis associated mutations are important biomarkers metastasis prediction outcome improvement. Methods: In this study, we applied whole-exome sequencing to identify potential related mutation in 12 paired lung samples. Findings: We identified 1,702 SNVs 6,131 events 1,220 genes. Furthermore, several...