A5031570120- Lymphoma Diagnosis and Treatment
- RNA modifications and cancer
- Cancer Immunotherapy and Biomarkers
- Perfectionism, Procrastination, Anxiety Studies
- Job Satisfaction and Organizational Behavior
- Radiomics and Machine Learning in Medical Imaging
- Advanced Radiotherapy Techniques
- Cancer Genomics and Diagnostics
- Lung Cancer Treatments and Mutations
- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Mentoring and Academic Development
Nanjing University of Information Science and Technology
2025
Sun Yat-sen University
2020-2023
State Key Laboratory of Oncology in South China
2022-2023
Guangdong Pharmaceutical University
2023
The potential value of epigenetic DNA methylation in early cancer screening has been demonstrated. Therefore, this study, we performed QMS-PCR and quantitative reverse transcription PCR on the genes RASSF1A, H4C6, SEPT9, GSTP1, PAX1, SHOX2, SOX2, which are common epithelial cancers. We found hypermethylation H4C6 SEPT9. mRNA expressions SEPT9 tumor group were significantly different from those inflammatory healthy (P < .05). Receiver operating characteristic (ROC) analysis showed that area...
Background: An increasing number of clinical trials are being conducted exploring the efficacy neoadjuvant immune checkpoint inhibitors. Surrogate endpoints for overall survival (OS) urgently needed.Methods: Phase II or III immunotherapy that reported data on OS and surrogate were identified from January 1, 2000, to November 25, 2022. Individual patient data, trial-level requested corresponding authors extracted eligible trials. At individual level, associations between radiological...
Background: Lung cancer is the most aggressive which representing one-quarter of all cancer-related deaths, and metastatic spread accounts for >70% these especially brain metastasis. Metastasis associated mutations are important biomarkers metastasis prediction outcome improvement. Methods: In this study, we applied whole-exome sequencing to identify potential related mutation in 12 paired lung samples. Findings: We identified 1,702 SNVs 6,131 events 1,220 genes. Furthermore, several...
Background: An increasing number of clinical trials are being conducted exploring the efficacy neoadjuvant immune checkpoint inhibitors. Surrogate endpoints for overall survival (OS) urgently needed.Methods: Phase II or III immunotherapy that reported data on OS and surrogate were identified from January 1, 2000, to November 20, 2021. Individual patient requested corresponding authors extracted eligible trials. At individual level, associations between radiological pathological response...