Glioma is one of the most common primary malignancies central nervous system, which has aggressive clinical behavior and a poorer prognosis. MicroRNAs (miRs) are class small noncoding RNAs that function as mediators gene expression, can be sponged by circRNA provided with closed circular structure. Dysregulations (circRNAs) miRs have been implicated in development progression glioma. In current study, we investigated role RNA hsa_circ_0076248 mediating oncogenesis glioma sponging miR-181a to...

Microglia are the primary immune cells in central nervous system and undergo significant morphological transcriptional changes after traumatic brain injury (TBI). However, their exact contribution to pathogenesis of TBI is still debated remains be elucidated. In present study, thy-1 GFP mice received a colony-stimulating factor 1 receptor inhibitor (PLX3397) for 21 consecutive days, then were subjected moderate fluid percussion (FPI). Brain samples collected at day 3 days FPI flow cytometry...

Objective To analyze the long noncoding RNA (lncRNA) expression profile of glioblastoma multiforme (GBM) and identify prognosis-related lncRNAs, as well their related protein-coding genes functions. Method The lncRNA profiles were obtained by microarray in six samples each GBM normal brain tissue. lncRNAs expressed significantly different between two groups used to detect associations with patient survival time downloading data from Cancer Genome Atlas (TCGA). total RNA-sequencing 152...

Lung cancer is the most aggressive cancer, resulting in one-quarter of all cancer-related deaths, and its metastatic spread accounts for >70% these especially metastasis to brain. Metastasis-associated mutations are important biomarkers prediction outcome improvement.In this study, we applied whole-exome sequencing (WES) identify potential metastasis-related 12 paired lung brain samples.We identified 1,702 single nucleotide variants (SNVs) 6,131 mutation events among 1,220 genes....

Objectives The objective was to explore further the surgical treatment of posttraumatic skull base defects with cerebrospinal fluid (CSF) leak and identify most common factors affecting defect CSF retrospectively. Materials Methods This study included 144 patients head trauma having who had been surgically treated at Sun Yat-Sen Memorial Hospital University from 1998 June 2016. There were 113 (78.5%) males 31 (21.5%) females, age ranging 1 78 years mean 26.58 ± 14.95 years. We explored...

Glioma is the most common and fatal primary cranial tumor. The epidermal growth factor receptor (EGFR) plays an important role in occurrence treatment of glioma, which might function through a circular ribonucleic acid (circRNA)-related mechanism. Hsa_circ_0080229 (circ_0080229) has been identified as circRNA arising from EGFR gene gliomas; however, little known about its molecular mechanism to date.To address this question, series experiments were conducted confirm effect circ_0080229...

A series of simple logic gates based on a water-soluble porphyrin molecule, 5,10,15,20-tetrakis-(4-sulfonatophenyl)porphyrin (TPPS 4 ) is designed. Logic operations, including OR, NOR, INHIBIT and AND, have been built by two inputs acid/base or metal ions (Al 3+ and/or Sn 4+ outputs UV-vis absorption fluorescent spectra. An OFF–ON switch triggered Al ion in vitro developed TPPS .

Primary central nervous system lymphoma (PCNSL), a highly malignant and infrequent tumor, is rarely found within the fourth ventricle. Here we report case of isolated ventricle: 61-year-old male presented with headache, mental disorder, abnormal gait urinary incontinence. Based on clinical symptoms neuroimage, He was initially diagnosed as choroid plexus papilloma. However, post-surgery pathology corrected diagnosis diffuse large B-cell lymphoma. To best our knowledge, only nine cases are...

Objective To explore endoscopic transnasal combined transeranial resection of anterior-middle skull base communicative tumors. Method 13 patients with fronto-naso-orbital tumors were treated extend subfrontal approach and reconstruction. Results Tumors totally removed in 11 cases subtotally 2 which malignant In all cases, there 4 neurinoma,3 nasopharyngeal fibroangioma,2 meningeoma, 1 hypophysoma, inverted papilloma, squamous cell carcinoma enthesioneuroblastoma. No serious operative...

Objective To study the therapeutic effect of pedicled subgaleal and pericranial flap in repair anterior skull base defects. Method A coronal operative incision hairline scalp was made to cut galea aponeurotica, a sharp dissection carried out along with deep surface aponeurotica. The size designed based on defect type area, loose connective tissue together pericranium as one layer stripped from make for 41 patients defects, which 15 caused by trauma 26 tumor surgery. Results area all cases...

To develop and validate a preoperative index-based nomogram for the prediction of hypokalemia in patients with pituitary adenoma (PA).This retrospective cohort study included 205 PAs between January 2013 April 2020 Sun Yat-sen Memorial Hospital, Guangzhou, China. The were randomly classified into either training set (N = 143 patients) validation 62 at ratio 7:3. Variables, which identified by using LASSO regression model construction nomogram, logistic analysis was used to calculate odds...

Objective To investigate the experience of early diagnosis and surgical treatment brain metastases to improve therapy effect. Methods Retrospective analysis was performed on clinical data 80 patients with metastases, received in our hospital from January 2003 December 2013. The diagnosis, survival these were analyzed. Results Asymptomatic regularly head computerized tomography (CT) or enhanced magnetic resonance imaging (MRI) found 12 (15%). Two weeks after surgery, 32 (40.0%)...

Objective To study the safety and efficacy of bioabsorbable fixation system for repositioning cranial bone flaps after posterior fossa craniotomy in children.Methods From July 2010 to March 2012,15 patients with tumor underwent surgery this institute.Bioabsorbable was used reposition flaps.After surgery,the healing surgical incisions recovery conditions were observed retrospectively analyzed.Results After operation,no pain,infection,redness swelling incision observed.CT or MRI scan showed...

Objective To study the anatomical classification and surgical management of communicating tumors invading anterior or middle skull base. Methods According to location growth direction tumors, base in 29 patients were classified into 4 types, namely fronto-naso-orbital 16 cases, middle-lateral cranial 8 central-medial cases petrous bone-jugular foramen tumor 1 case. Based on this classification, extended transbasal approach (13 cases), supraorbital-pterional (9 fronto-temporal (3...

Background: Lung cancer is the most aggressive which representing one-quarter of all cancer-related deaths, and metastatic spread accounts for >70% these especially brain metastasis. Metastasis associated mutations are important biomarkers metastasis prediction outcome improvement. Methods: In this study, we applied whole-exome sequencing to identify potential related mutation in 12 paired lung samples. Findings: We identified 1,702 SNVs 6,131 events 1,220 genes. Furthermore, several...