A5053510214- Helicobacter pylori-related gastroenterology studies
- Advanced biosensing and bioanalysis techniques
- Cerebrovascular and Carotid Artery Diseases
- Acute Ischemic Stroke Management
- Cancer Cells and Metastasis
- Veterinary medicine and infectious diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- Rough Sets and Fuzzy Logic
- Cancer Research and Treatments
- Salivary Gland Disorders and Functions
- Circular RNAs in diseases
- Opinion Dynamics and Social Influence
- Intracranial Aneurysms: Treatment and Complications
- Digestive system and related health
- AI in cancer detection
- Alzheimer's disease research and treatments
- MicroRNA in disease regulation
- RNA Interference and Gene Delivery
- Blockchain Technology Applications and Security
- Cancer-related molecular mechanisms research
- Semantic Web and Ontologies
- vaccines and immunoinformatics approaches
- Galectins and Cancer Biology
- Lipid metabolism and disorders
- Gastric Cancer Management and Outcomes
Renji Hospital
2024-2025
Shanghai Jiao Tong University
2024-2025
State Key Laboratory of Oncogene and Related Genes
2024-2025
Sun Yat-sen Memorial Hospital
2014-2024
Sun Yat-sen University
2014-2024
Shanghai Normal University
2024
South China Sea Institute Of Oceanology
2023-2024
Liupanshui Normal University
2022-2024
Guangdong Provincial People's Hospital
2023-2024
Guangdong Academy of Medical Sciences
2023-2024
The necessity for new sources greener and cleaner energy production to replace the existing ones has been increasingly growing in recent years. Of those sources, hydrogen evolution reaction a large potential. In this work, first time, MoSe2 /Mo core-shell 3D-hierarchical nanostructures are created, which derived from Mo through low-temperature plasma-assisted selenization process with controlled shapes grown by glancing angle deposition system.
Abstract Background Recent evidences have shown that circular RNAs (circRNAs) are frequently dysregulated and play paramount roles in various cancers. circRNAs abundant central nervous system (CNS); however, few studies describe the clinical significance role of gliomas, which is most common aggressive primary malignant tumor CNS. Methods A bioinformatics analysis was performed to profile screen dyregulated during early neural development. Quantitative real-time PCR used detect expression...
Abstract A 3D DNA spatial chip (DSC) based on an icosahedral origami framework is introduced to construct customized circular single‐stranded (c‐ssDNA) for data storage. Within the confined space of DSC, thirty addressable location sequences extending from edges are available designing paths and directing assembly a series information oligonucleotides efficient ligation. This strategy verified by constructing c‐ssDNAs up 15 fragments encode two poems (800 860 nucleotides). Using orthogonal...
Antibiotic resistance to amoxicillin in second-line eradication therapy for Helicobacter pylori infection is much less frequent than metronidazole. We conducted a randomized, controlled study compare the efficacies of standard quadruple rescue and new with replacing metronidazole patients failing first-line treatment. randomly assigned 120 who failed H. using proton pump inhibitor plus clarithromycin undergo 1-week esomeprazole, bismuth subcitrate, tetracycline either (EBTM group, n = 62) or...
Abstract This large-scale survey aimed to evaluate frequencies and patterns of Chinese herbal medicine (CHM) used for Sjögren's syndrome (SS) in Taiwan by analyzing the National Health Insurance Research Database (NHIRD) cases which CHM was as an alternative therapy Western improving patients' discomforts. We analyzed SS principal diagnosis (ICD-9:710.2) with a catastrophic illness certificate (CIC) traditional (TCM) outpatient clinics from three cohorts Longitudinal (LHID) NHIRD between...
Abstract Activation of innate immunity in the brain is a prominent feature Alzheimer’s disease (AD). The present study investigated regulation by wild-type serum injection transgenic AD mouse model. We found that treatment with significantly reduced number neutrophils and microglial reactivity brains APP/PS1 mice. Mimicking this effect, neutrophil depletion via Ly6G neutralizing antibodies resulted improvements functions. Serum proteomic analysis identified vascular endothelial growth...
Abstract Mosaic nanoparticle vaccines with heterotypic antigens exhibit broad‐spectrum antiviral capabilities, but the impact of antigen proportions and distribution patterns on vaccine‐induced immunity remains largely unexplored. Here, we present a DNA nanotechnology‐based strategy for spatially assembling to guide rational design mosaic vaccines. By utilizing two aptamers orthogonal selectivity original SARS‐CoV‐2 spike trimer Omicron receptor‐binding domain (RBD), along soccer‐ball...
Gadolinium enhancement on high-resolution vessel wall imaging (HR-VWI) is an marker of intracranial atherosclerotic stenosis (ICAS) plaque instability. This study aimed to evaluate the relationships between hematological inflammatory indicators and ICAS plaques search for that can predict instability.Consecutive adult patients diagnosed with from April 2018 December 2021 were recruited retrospectively, every patient underwent HR-VWI. Plaque was measured qualitatively quantitatively. The...
The aim of this study was to develop an in vitro human gastric stem and/or progenitor cell model that may be used the mechanism carcinogenesis induced by Helicobacter pylori infection.Human biopsy minced and digested with collagenase dispase cultured a low-calcium medium (serum-free keratinocyte medium; keratinocyte-SFM) supplemented N-acetyl-L-cysteine L-ascorbic acid 2-phosphate. Actively proliferating epithelial colonies sustained growth were isolated characterized for karyotype...
The current study was to investigate the interaction between Helicobacter pylori and human dendritic cells (DCs). Whether impaired DC function can influence outcome of H. infections. Human monocyte-derived DCs (MDDCs) from five gastric cancer patients nine healthy controls were stimulated with pylori. Maturation markers MDDC examined by flow cytometry. IL-10 TNF-α released MDDCs IL-17 produced T measured ELISA. Regulatory signaling pathways ELISA, western blotting, chromatin...
Surface modification could enhance the cell internalization efficiency of nanovehicles for targeted gene or drug delivery. However, influence surface parameters, including recognition manners, valences, and patterns, is often clouded, especially endocytosis DNA nanostructures in customized shapes. Focusing on an icosahedral framework, we systematically programmed three distinct types ligands with diverse valence spatial distribution their outer to study efficiency, endocytic pathways,...
Automatic and accurate segmentation of breast lesion regions from ultrasonography is an essential step for ultrasound-guided diagnosis treatment. However, developing a desirable method very difficult due to strong imaging artifacts e.g., speckle noise, low contrast intensity inhomogeneity, in ultrasound images. To solve this problem, paper proposes novel boundary-guided multiscale network (BGM-Net) boost the performance images based on feature pyramid (FPN). First, we develop enhancement...
Goal Study the mechanism of gastric tumor development. Background We have generated and characterized a novel human cell line, KMU-CS12 (CS12), from an immortal KMU-CSN (CSN; formerly named as GI2CS−) which was derived putative stem cell/progenitor clone, KMU-GI2. The characterization CS12 line includes gene expression by immunocytochemical staining, proliferation differentiation potential, cyotogenetic analysis Giemsa banding spectral karyotype (SKY), tumorigenicity in immune-deficient...
Abstract Emerging technologies such as blockchain have accelerated the digitization of a variety industries, improved operational efficiency enterprises, and promoted in-depth integration digital technology with real economy. Blockchain has characteristics that include distributed storage, peer-to-peer transmission, strong confidentiality, easy traceability. This article introduces into an enterprise’s information management system aim breaking barriers by using ledgers, smart contracts,...