A5043644940- Neuroinflammation and Neurodegeneration Mechanisms
- Alzheimer's disease research and treatments
- Neurogenesis and neuroplasticity mechanisms
- Ruminant Nutrition and Digestive Physiology
- Neuroscience and Neuropharmacology Research
- Immune Response and Inflammation
- Antioxidant Activity and Oxidative Stress
- Effects of Environmental Stressors on Livestock
- Nuts composition and effects
- Immune responses and vaccinations
- Genetic and phenotypic traits in livestock
- Advanced Glycation End Products research
- Parkinson's Disease Mechanisms and Treatments
- Retinoids in leukemia and cellular processes
- Meat and Animal Product Quality
- Water Quality Monitoring Technologies
- Metabolomics and Mass Spectrometry Studies
- Amyotrophic Lateral Sclerosis Research
- Pharmacological Effects of Natural Compounds
- Essential Oils and Antimicrobial Activity
- Neuroendocrine Tumor Research Advances
- Phytoestrogen effects and research
- Phytochemicals and Antioxidant Activities
- Animal Nutrition and Physiology
- Biochemical Analysis and Sensing Techniques
Ministry of Agriculture and Rural Affairs
2025
Anhui Agricultural University
2025
Shanxi Datong University
2025
Sun Yat-sen University
2014-2023
The First Affiliated Hospital, Sun Yat-sen University
2023
University of Science and Technology of China
2020
Nanjing University
2020
Beijing University of Agriculture
2011-2016
Xinjiang Medical University
2014-2015
Zero to Three
2014
The plant-specific YABBY transcription factor family plays several activities, including responding to abiotic stress, establishing dorsoventral polarity, and developing lateral organs. Cucumis sativus L. commonly referred as cucumber one of the first vegetable crops with a fully sequenced genome. In this work, we examined application NAA, CPPU, GA4 + 7 inflict parthenocarpy in ZK line. expression pattern genes throughout fruit development performed genomic census (Cucumis L.). Based on...
Glioblastoma (GBM) is the most common type of malignant tumor central nervous system. The prognosis patients with GBM very poor, a survival time ~15 months. highly heterogeneous and aggressive. Surgical removal intracranial tumors does provide good advantage for as there high rate recurrence. understanding this cancer needs to be strengthened, aim present study was identify gene signatures in uncover their potential mechanisms. expression profiles GSE15824 GSE51062 were downloaded from Gene...
Standardized Ginkgo biloba extract, EGb761, has been shown to possess polyvalent properties, such as anti-oxidation, anti-apoptosis and anti-inflammation. Recently, it also proposed have direct protective effects on mitochondria. The of EGb761 make a potential anti-aging drug. Despite that, the 'anti-aging' effect particularly its central nervous system, is still inconclusive. Using two age groups (3-week-old 40-week-old) SAMP8 mice (a senescence-accelerated strain mice), mitochondrial...
The spatial learning abilities of developing mice benefit from extrinsic cues, such as an enriched environment, with concomitant enhancement in cognitive functions. Interestingly, enhancements can be further increased through intrinsic Bacillus Calmette-Guérin (BCG) vaccination. Here, we first report that combined neonatal BCG vaccination and exposure to environment (Enr) induced neurobeneficial effects, including hippocampal long-term potentiation, neurogenesis memory, exposed the Enr...
Oxidative stress (OS) plays an important role in neurodegenerative diseases such as Alzheimer's disease (AD). Lycopene is a pigment with potent antioxidant and anti-tumor effects. However, its potential central nervous system not well-defined. The aim of this study was to investigate the effect lycopene on cell model AD determine underlying mechanisms.M146L double-transfected (human APP gene presenlin-1 gene) Chinese hamster ovary (CHO) line that overexpresses β -amyloid (Aβ) ideal for AD....
Extracellular aggregation of the β-amyloid (Aβ) peptide into toxic multimers in brain is a prominent event occurring pathogenesis Alzheimer's disease (AD), and large amount Aβ blood derived from platelets. Thus, we speculated that platelets may play an important role process AD. We first investigated changes platelet secretion with age. Then, injected aged amyloid precursor protein APP/PS1 mice young C57 assessed their memory capacity along peripheral expression levels. The content mouse...
Abstract Activation of innate immunity in the brain is a prominent feature Alzheimer’s disease (AD). The present study investigated regulation by wild-type serum injection transgenic AD mouse model. We found that treatment with significantly reduced number neutrophils and microglial reactivity brains APP/PS1 mice. Mimicking this effect, neutrophil depletion via Ly6G neutralizing antibodies resulted improvements functions. Serum proteomic analysis identified vascular endothelial growth...
Prenatal infection is a substantial risk factor for neurodevelopmental disorders such as autism in offspring. We have previously reported that influenza vaccination (VAC) during early pregnancy contributes to neurogenesis and behavioral function Here, we probe the efficacy of VAC pretreatment on autism-like behaviors lipopolysaccharide (LPS)-induced maternal immune activation (MIA) mouse model. show improves abnormal fetal brain cytoarchitecture lamination, an effect associated with...
Niche astrocytes have been reported to promote neuronal differentiation through juxtacrine signaling. However, the effects of on following ischemic stroke are not fully understood. In present study, transplanted and neural stem cells (NSCs) were into striatum transient middle cerebral artery occlusion (MCAO) model rats 48 h surgery. It was observed that co-transplantation NSCs resulted in a higher ratio survival proliferation NSCs, differentiation, MCAO compared with NSC transplantation...
Many traditional Chinese medicine (TCM) decoctions are proven to have multiple functions in animal production. These seldom recognized by the international scientific community because mechanisms of action not clearly elucidated. According TCM theory, Cortex Phellodendri (COP), Rhizoma Atractylodes (RA), Agastache Rugosa (AR), and Gypsum Fibrosum (GF) can be used formulate a medicinal compound that prevents or cures disease caused heat stress. The aim this research was study regulatory...
Polyphenols extracted from plants have multiple functions in animal production. To explore new sources of tannin-rich extracts, which potential benefits for health, this study focused on the effects polyphenolic extracts involucres Castanea mollissima Blume (PICB) heat-stressed broilers. In vitro experiments were first performed using intestinal cryptlike epithelial cell line-6 (IEC-6) cells to evaluate PICB proliferation and antioxidative parameters under normal heat-stress conditions. Then...
The present study evaluated the effect of hypoxia on expression progranulin in HT22 mouse hippocampal cells. To investigate (PGRN) and alterations its following hypoxia, cells were treated with various concentrations sodium hydrosulfite (Na2S2O4; 1‑20 mM) for a fixed time (6 h) or concentration (5 different lengths (2‑10 h). PGRN was analyzed by an immunocytochemistry assay western blot analysis. data revealed that capable expressing PGRN. Double labeling results able to co‑localize neuronal...
The aging brain with mitochondrial dysfunction and a reduced adenosine 5'-triphosphate (ATP) has been implicated in the onset progression of β-Amyloid (Aβ)-induced neuronal toxicity AD.To unravel function ATP underlying mechanisms on AD development, APP/PS1 double transgenic mice wildtype (WT) C57 at 6 10 months age were studied.We demonstrated decreased release hippocampus platelet mice, comparing to relatively early age.Levels Aβ raised both accompanied by decrease α-secretase activity an...
In recent years, Tibetan pig and Bama are popularly used as animal models for medical researches. However, little genomic information is available the two breeds, particularly regarding gene expression pattern at whole-transcriptome level. this study, we characterized pituitary transcriptome profile along their postnatal developmental stages within between breeds in order to illustrate differential dynamics functions of differentially expressed genes. We obtained a total ∼300 million 80-bp...