A5028316670- Metabolomics and Mass Spectrometry Studies
- Gut microbiota and health
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Alzheimer's disease research and treatments
- Mitochondrial Function and Pathology
- Probiotics and Fermented Foods
- Immune cells in cancer
- Bioinformatics and Genomic Networks
- Neuroinflammation and Neurodegeneration Mechanisms
- Diet and metabolism studies
- Metabolism and Genetic Disorders
- Infant Nutrition and Health
- Ultrasound and Hyperthermia Applications
- Asthma and respiratory diseases
- Pharmacological Effects of Natural Compounds
- Ferroptosis and cancer prognosis
- Spinal Cord Injury Research
- Gastrointestinal motility and disorders
- Effects of Radiation Exposure
- Barrier Structure and Function Studies
- Folate and B Vitamins Research
- Traditional Chinese Medicine Studies
- Recycled Aggregate Concrete Performance
- Nerve Injury and Rehabilitation
- RNA modifications and cancer
Wuhan University of Science and Technology
2025
Helmholtz Zentrum München
2021-2025
Suzhou Traditional Chinese Medicine Hospital
2024
General Hospital of Shenyang Military Region
2024
Center for Environmental Health
2021-2024
Changchun University of Chinese Medicine
2024
The First Affiliated Hospital, Sun Yat-sen University
2023
Sun Yat-sen University
2022-2023
Air Force Medical University
2023
State Key Laboratory of Food Science and Technology
2020-2022
The human gut microbiome is a complex ecosystem that closely related to the aging process. However, there currently no reliable method make full use of metagenomics data determine age host. In this study, we considered influence geographical factors on microbiome, and total 2604 filtered from were used construct an prediction model. Then, developed ensemble model with multiple heterogeneous algorithms combined species pathway profiles for multi-view learning. By integrating adjusting host...
Impaired glucose uptake in the brain is an early presymptomatic manifestation of Alzheimer's disease (AD), with symptom-free periods varying duration that likely reflect individual differences metabolic resilience. We propose a systemic "bioenergetic capacity", ability to maintain energy homeostasis under pathological conditions. Using fasting serum acylcarnitine profiles from AD Neuroimaging Initiative as blood-based readout for this capacity, we identified subgroups distinct clinical and...
Tetrastigma hemsleyanum, a precious edible and medicinal plant in China, has attracted extensive research attention recent years due to its high traditional value for the treatment of various diseases. In vitro digestion colonic fermentation models were established evaluate stability hemsleyanum leaves (THL) phenolics by HPLC-QqQ-MS/MS method. The total phenolic flavonoid contents degraded during fermentation. 3-caffeoylquinic acid, 5-caffeoylquinic orientin (iso)vitexin metabolized...
Abstract Activation of innate immunity in the brain is a prominent feature Alzheimer’s disease (AD). The present study investigated regulation by wild-type serum injection transgenic AD mouse model. We found that treatment with significantly reduced number neutrophils and microglial reactivity brains APP/PS1 mice. Mimicking this effect, neutrophil depletion via Ly6G neutralizing antibodies resulted improvements functions. Serum proteomic analysis identified vascular endothelial growth...
This study employed Mendelian Randomization (MR) to investigate the causal relationships among immune cells, COPD, and potential metabolic mediators. Utilizing summary data from genome-wide association studies, we analyzed 731 cell phenotypes, 1,400 plasma metabolites, COPD. Bidirectional MR analysis was conducted explore links between cells complemented by two-step mediation multivariable identify mediating metabolites. Causal were identified 41 phenotypes with 6 exhibiting reverse...
(1) Background: Constipation is a common condition that affects the health and quality of life patients. Recent studies have suggested gut microbiome associated with constipation, but these were mainly focused on single research cohort. Thus, we aimed to construct classification model based fecal bacterial identify potential microbes' biomarkers. (2) Methods: We collected 3056 amplicon sequence data from five cohorts. The subjected series analyses, including alpha- beta-diversity...
ABSTRACT INTRODUCTION Embedding single-omics disease associations into the wider context of multi-level molecular changes in Alzheimer’s (AD) remains one central challenge AD research. METHODS Results from numerous AD-specific omics studies AMP-AD, NIAGADS, and other initiatives were integrated a comprehensive network resource complemented with large-scale population-based to provide global view on AD. RESULTS We present Atlas, an online ( www.adatlas.org ) integrating over 20 large...
Spinal cord injury (SCI) results in severe motor and sensory dysfunction with no effective therapy. debris (sp) from injured spinal evokes secondary SCI continuously. We other researchers have previously clarified that it is mainly bone marrow derived macrophages (BMDMs) infiltrating the lesion epicenter to clear sp, rather than local microglia. Unfortunately, pro-inflammatory phenotype of these BMDMs predominant which impairs wound healing. Hydralazine, as a potent vasodilator scavenger...
Abstract Impaired glucose uptake in the brain is one of earliest presymptomatic manifestations Alzheimer’s disease (AD). The absence symptoms for extended periods time suggests that compensatory metabolic mechanisms can provide resilience. Here, we introduce concept a systemic ‘bioenergetic capacity’ as innate ability to maintain energy homeostasis under pathological conditions, potentially serving such mechanism. We argue fasting blood acylcarnitine profiles an approximate peripheral...
Objective Dietary factors and nutritional status may be among the risk for Chronic Obstructive Pulmonary Disease (COPD). There exists a certain correlation between trace elements COPD. Through Mendelian Randomization (MR) analysis, we investigated causal relationships elements, inflammatory proteins, Methods We employed MR, multivariable MR (MVMR), two-step (TSMR) approaches to assess links 15 COPD, with 91 proteins serving as mediators further elucidate tripartite relationships. Results...
To employ bioinformatics and machine learning to predict the characteristics of immune cells genes associated with inflammatory response ferroptosis in chronic obstructive pulmonary disease (COPD) patients aid development targeted traditional Chinese medicine (TCM). Mendelian randomization analysis elucidates causal relationships among cells, genes, COPD, offering novel insights for early diagnosis, prevention, treatment COPD. This approach also provides a fresh perspective on use treating
Objective Lung cancer, the most prevalent malignancy, is typically diagnosed at an advanced stage. Smoking a pivotal risk factor for NSCLC, yet impact of various smoking statuses on NSCLC remains unclear. Thus, this study aims to explore whether different can causally influence through effects predictive targets, offering novel perspective treatment. Methods Employing dual-sample MR, MVMR, and TSMR approaches, we assessed causal relationships between 13 distinct using predicted potential...
The gut microbiota and its metabolites exert a significant influence on COPD, yet the underlying mechanisms remain elusive. We aim to holistically evaluate role of in COPD through network pharmacology Mendelian randomization approaches.
ABSTRACT Increasing evidence suggests the involvement of metabolic alterations in neurological disorders, including Alzheimer’s disease (AD), and highlights significance peripheral metabolome, influenced by genetic factors modifiable environmental exposures, for brain health. In this study, we examined 1,387 metabolites plasma samples from 1,082 dementia-free middle-aged participants population-based Rotterdam Study. We assessed relation with general cognition (G-factor) magnetic resonance...
Abstract Background Brain glucose hypometabolism is among the earliest pathogenic changes in Alzheimer’s disease (AD). This metabolic dysfunction points to personal bioenergetic capacity, defined as ability maintain energy homeostasis under all circumstances including deregulated uptake, a potential source of resilience disease. Fasting blood acylcarnitine profiles are central readout for this capacity absence dietary and capture activity efficiency glucose‐independent routes mitochondrial...
Abstract Background Increasing evidence suggests a role of metabolism in neurological disorders including Alzheimer’s disease (AD). The human metabolome is determined by genes and modifiable factors such as gut microbiota, diet, medication, other lifestyle choices. We hypothesized that metabolites related to endophenotypes brain health maybe derived or influenced these factors. Identifying the determinants associated with AD‐related may help discover new targets for drugs prevention. Method...
Abstract Activation of innate immunity in the brain is a prominent feature Alzheimer's disease (AD). The present study investigated regulation by young serum transgenic AD mouse model. We found that significantly reduced number neutrophils and microglial reactivity brains APP/PS1 mice. Neutrophil depletion via Ly6G neutralizing antibodies mimicked benefits on functions. Serum proteomic analysis revealed significant enrichment factors VEGF-A CXCL1, which are crucial for neutrophil migration...