A5022335551- Cold Atom Physics and Bose-Einstein Condensates
- Quantum, superfluid, helium dynamics
- Physics of Superconductivity and Magnetism
- Cell Adhesion Molecules Research
- Cancer Genomics and Diagnostics
- Atomic and Subatomic Physics Research
- Advanced Condensed Matter Physics
- Cervical Cancer and HPV Research
- Cancer Cells and Metastasis
- Quantum Information and Cryptography
- Magnetic properties of thin films
- Renal cell carcinoma treatment
- Atrial Fibrillation Management and Outcomes
- Protease and Inhibitor Mechanisms
- Renal and related cancers
- Cancer-related molecular mechanisms research
- Gyrotron and Vacuum Electronics Research
- Lung Cancer Treatments and Mutations
- Ovarian cancer diagnosis and treatment
- Head and Neck Cancer Studies
- Salivary Gland Tumors Diagnosis and Treatment
- Proteoglycans and glycosaminoglycans research
- Quantum and electron transport phenomena
- AI in cancer detection
- Cardiac Arrhythmias and Treatments
Guangxi University
2020
Oklahoma State University
2010-2019
University of Oklahoma Health Sciences Center
2008-2018
Central Texas Veterans Health Care System
2018
OU Health
2017
University of Oklahoma
2009-2016
OU Health Stephenson Cancer Center
2016
Oklahoma State University Oklahoma City
2016
General Hospital of Jinan Military Command
2015-2016
Oklahoma City University
2009-2015
Background— The mechanism(s) for acute changes in electrophysiological properties of the atria during rapid pacing induced atrial fibrillation (AF) is not completely understood. We sought to evaluate contribution intrinsic cardiac autonomic nervous system electrical remodeling and AF by 6-hour pacing. Methods Results— Continuous (1200 bpm, 2� threshold [TH]) was performed at left appendage. Group 1 (n=7) underwent immediately followed ganglionated plexi (GP) ablation; group 2 GP ablation...
Renal clear cell carcinoma (RCC) is the most common type of kidney cancer and 8th overall in US. RCC survival rates drop precipitously with regional distant spread recent studies have demonstrated that presents an epithelial-mesenchymal transition (EMT) phenotype linked to increased recurrence decreased survival. EMT a key characteristic tumor stem cells (TSCs) along chemo-resistance radio-resistance, which are also phenotypic RCC. Targeting these factors increasing patients....
We experimentally study spin dynamics in a sodium antiferromagnetic spinor condensate as result of spin-dependent interactions $c$ and microwave dressing field characterized by the net quadratic Zeeman effect ${q}_{\mathrm{net}}$. In contrast to magnetic fields, fields enable us access both negative positive values find an experimental signature determine sign ${q}_{\mathrm{net}}$ observe harmonic population oscillations at every except near each separatrix phase space where oscillation...
RET fusions have been found in lung adenocarcinoma, of which KIF5B-RET is the most prevalent. We established inducible transgenic mice and KIF5B-RET-dependent cell lines for preclinical modeling KIF5B-RET-associated adenocarcinoma. Doxycycline-induced CCSP-rtTA/tetO-KIF5B-RET developed invasive adenocarcinoma with desmoplastic reaction. Tumors regressed upon suppression expression. By culturing BaF3 (B/KR) cells increasing concentrations cabozantinib or vandetanib, we identified...
Renal cell carcinoma (RCC) is a common and devastating disease characterized by hypoxic microenvironment, epithelial‐mesenchymal transition potent resistance to therapy evidencing the presence of cancer stem cells (CSCs). Various CSC markers have been studied in RCC, but overall there limited data on their role most relatively nonspecific. Doublecortin‐like kinase 1 (DCLK1) validated marker gastrointestinal tract evidence for an equivalent other cancers accumulating. We used bioinformatics,...
Doublecortin-like kinase 1 (DCLK1) is a putative pancreatic stem cell marker and upregulated in cancer, colorectal many other solid tumors. It marks tumor cells mouse models of intestinal neoplasia. Here we sought to determine whether DCLK1 protein can be detected the bloodstream if its levels archived serum samples could quantitatively assessed cancer patients. specific ELISA, western blotting, immunohistochemical analyses were used expression staining intensity tissues ductal...
We evaluated the detection rates of PAX8 and WT1 immunostaining in 68 (45 as cell blocks, 23 smears) serous effusion specimens that had a cytologic diagnosis metastatic carcinoma ovarian origin. Of cases, 58 (85%) were positive for PAX8, 56 (82%) WT1, 64 (94%) immunoreactive with either or both markers. Detection 85% (44/52) 92% (48/52), respectively, 100% (5/5) 20% (1/5), clear carcinoma. using blocks smears 91% 78%, 82% 83%, WT1. concluded comparable overall confirming origin malignant...
Shear-resistant adhesion and extravasation of disseminated cancer cells at the target organ is a crucial step in hematogenous metastasis. We found that vascular molecule E-selectin preferentially promoted shear-resistant transendothelial migration estrogen receptor (ER)(-)/CD44(+) hormone-independent breast cells, but not ER(+)/CD44(-/low) hormone-dependent cells. Coincidentally, CD44(+) were abundant metastatic lung brain lesions ER(-) cancer, suggesting supports metastasis ER(-)/CD44(+)...
The adhesion molecule L-selectin is cleaved rapidly from the surface of activated leukocytes by tumor necrosis factor-α converting enzyme, a cell metalloprotease, and also undergoes slower constitutive shedding in unactivated cells. structural features that render it susceptible to are poorly understood. We therefore analyzed series mutant chimeric molecules. Although murine at specific location juxtamembrane region 11 amino acids distal membrane, this cleavage has little sequence...
the mechanism underlying spontaneous rapid superior vena cava (SVC) firing that initiates atrial fibrillation (AF) remains poorly understood. We investigated role of SVC-aorta-ganglionated plexus (SVC-Ao-GP) in AF initiated by from SVC.in 42 dogs, a circular catheter was positioned above SVC-atrial junction. Multielectrode catheters were sutured on atria, appendages and pulmonary veins. The effective refractory period (ERP) window vulnerability (WOV) for measured at all sites baseline state,...
We experimentally demonstrate that spin dynamics and the phase diagram of spinor condensates can be conveniently tuned by a two-dimensional optical lattice. Spin population oscillations lattice-tuned separatrix in space are observed every lattice where substantial superfluid fraction exists. In sufficiently deep lattice, we observe transition from longitudinal polar to broken-axisymmetry steady states lattice-confined condensates. The found depend sigmoidally on depth exponentially magnetic...
We present an experimental study on nonequilibrium dynamics of a spinor condensate after it is quenched across superfluid to Mott insulator (MI) phase transition in cubic lattices. Intricate consisting spin-mixing oscillations at multiple frequencies are observed time evolutions the localized deep lattices quantum quench. Similar spin also appear gases MI suddenly moved away from their ground states via quenching magnetic fields. confirm these spectra can be utilized reveal atom number...
We experimentally study two quantum phase transitions in a sodium spinor condensate immersed microwave dressing field. also demonstrate that many previously unexplored regions the diagram of condensates can be investigated by adiabatically tuning field across one transitions. This method overcomes major experimental challenges associated with some widely used methods, and is applicable to other atomic species. Agreements between our data mean-field theory for Bose gases are discussed.
// Janani Panneerselvam 1, 4 , Akhil Srivastava Ranganayaki Muralidharan Qi Wang Wei Zheng 1 Lichao Zhao Alshine Chen 3, Yan D. Anupama Munshi 2, Rajagopal Ramesh 4, 5 Department of Pathology, The University Oklahoma Health Sciences Center, City, 73104, USA 2 Radiation Oncology, 3 Biostatistics and Epidemiology, Stephenson Cancer Graduate Program in Biomedical Sciences, Correspondence to: Ramesh, email: rajagopal-ramesh@ouhsc.edu Keywords: IL-24, lung cancer, HMGA1, miR222-3p, metastasis...
Objectives Preferential use of fine‐needle aspiration (FNA) versus core needle biopsy (CNB) for distinguishing benign from malignant major salivary gland tumors is highly debated. The main disadvantage FNA lower sensitivity, whereas arguments against CNB include a larger bore and greater risk complications. aim this study to evaluate our experience performing ultrasound‐guided (UG) with selective based on preliminary cytopathology, determine whether preoperative diagnostic approach more...
Adequacy assessment for fine-needle aspiration procedures is a standard of care in large medical centers. Although the benefits this approach include higher adequacy rates with fewer passes, it costs cytopathologist time and affects other clinical responsibilities. The objective current study was to evaluate use mobile video streaming (FaceTime) technology help smartphone adapters attached microscopes remote cytologic samples.The consisted 2 phases: Phase 1 retrospective 25 samples by...
We observe evidence of first-order superfluid to Mott-insulator quantum phase transitions in a lattice-confined antiferromagnetic spinor Bose-Einstein condensate. The observed signatures include hysteresis effect and significant heatings across the transitions. nature is found strongly depend on ratio quadratic Zeeman energy spin-dependent interaction. Our observations are qualitatively understood by mean field theory, addition suggest tuning new approach realize
We present a simple and optimal experimental scheme for an all-optical production of sodium spinor Bose-Einstein condensate (BEC). With this scheme, we demonstrate that the number atoms in pure BEC can be greatly boosted by factor 5 over some widely used schemes single-beam or crossed-beam optical trap. Our avoids technical challenges associated with methods may applicable to other optically trappable atomic species. In addition, discuss upper limit evaporative cooling efficiency approaches...
Although trastuzumab has succeeded in breast cancer treatment, acquired resistance is one of the prime obstacles for therapies. There an urgent need to develop novel HER2 antibodies against resistance. Here, we first rational designed avidity-imporved and pertuzumab variants, explored correlation between binding avidity improvement their antitumor activities. After characterization a variant L56TY with potent activities, bispecific immunoglobulin G-like CrossMab (Tras-Permut CrossMab) was...
BACKGROUND Recent proposals to lengthen the interval in cervical cancer screening highlight importance of accurate interpretation tests. Tumor debris present Papanicolaou (Pap) tests from women with invasive is known hamper interpretation. The current study evaluated limiting factors Pap cancer. METHODS A total 3003 spectrum lesions who had ThinPrep (Hologic Inc, Marlborough, Mass) and human papillomavirus (HPV) genotyping performed were grouped by their most severe histologic diagnosis....
CD62L (L-selectin) is a key regulator of T cell trafficking, and its surface expression on activated cells modulated to control access lymph nodes after acute infections. In memory cells, the most frequently used marker define central population that provides enhanced protection against most, but not all, pathogens. Early CD62L(pos) effector has been proposed result in preferential differentiation, direct proof for involvement node homing differentiation lacking. this study, we show lineage...
Objectives To evaluate the diagnostic performance of ultrasound (US)‐guided fine‐needle aspiration with optional core needle biopsy head and neck lymph nodes masses, attention to differences between treated squamous cell carcinoma (SCC) other lesions. Methods Institutional Review Board approval was obtained, need for consent waived this retrospective study. All 861 US‐guided biopsies masses performed March 1, 2012, May 16, 2016, were reviewed. Results Of biopsies, 53 targeted SCC residual...
To evaluate the efficacy and limitation of fine-needle aspiration (FNA) biopsy in thyroid bed lesions, a retrospective review was performed medical records cancer patients who underwent ultrasound-guided FNA at The University Texas MD Anderson Cancer Center over 5-year period.Data were reviewed on 220 biopsies taken from lesions 195 had undergone thyroidectomy for carcinoma. Thyroid results compared with clinical follow-up, including neck dissection results.Recurrent carcinoma diagnosed by...