A5087665351- Radiomics and Machine Learning in Medical Imaging
- Sarcoma Diagnosis and Treatment
- Lung Cancer Diagnosis and Treatment
- Medical Imaging Techniques and Applications
- Cancer Genomics and Diagnostics
- Lung Cancer Treatments and Mutations
- Musculoskeletal synovial abnormalities and treatments
- Mathematical Biology Tumor Growth
- Medical Imaging and Pathology Studies
- Lymphoma Diagnosis and Treatment
- CAR-T cell therapy research
- Microtubule and mitosis dynamics
- Renal and related cancers
- RNA modifications and cancer
- Advanced Electron Microscopy Techniques and Applications
- Ultrasound and Hyperthermia Applications
- Cancer, Hypoxia, and Metabolism
- Bioinformatics and Genomic Networks
- Bone Tumor Diagnosis and Treatments
- Neurofibromatosis and Schwannoma Cases
- Cancer Risks and Factors
- Chronic Lymphocytic Leukemia Research
- Rheumatoid Arthritis Research and Therapies
- Chromatin Remodeling and Cancer
- Mycobacterium research and diagnosis
Moffitt Cancer Center
2016-2024
University of South Florida
2024
RET fusions have been found in lung adenocarcinoma, of which KIF5B-RET is the most prevalent. We established inducible transgenic mice and KIF5B-RET-dependent cell lines for preclinical modeling KIF5B-RET-associated adenocarcinoma. Doxycycline-induced CCSP-rtTA/tetO-KIF5B-RET developed invasive adenocarcinoma with desmoplastic reaction. Tumors regressed upon suppression expression. By culturing BaF3 (B/KR) cells increasing concentrations cabozantinib or vandetanib, we identified...
Lessons from extinction can be used in trials designed to pursue a cure for cancer. When cancer cannot cured, similar strategies may unwise, and that leverage the adaptations of therapy should considered.
Abstract The current paradigm of clinical trials treating patients until disease progression using maximum tolerated dose does not account for the dynamic tumor-host-drug interactions that result in acquired resistance. Here, we present concept an Evolutionary Tumor Board (ETB) and report interim results from a prospective, non-interventional pilot study which novel therapeutic strategies based on evolutionary principles were developed under ETB framework. approach relies interdisciplinary...
Kaposi sarcoma (KS) is an uncommon angioproliferative malignancy that associated with human herpesvirus 8. Although there has been recent enthusiasm for evaluating immune checkpoint inhibition as a therapeutic option viral-associated tumors, the clinical utility in this disease currently unknown. We report case of advanced classic KS refractory to multiple lines chemotherapy experienced partial response anti–PD-1 therapy. Comprehensive molecular profiling was performed on diagnostic tumor...
The combination of gemcitabine and docetaxel is often used to treat patients with recurrent sarcoma. Nab-paclitaxel a taxane modified improve drug exposure increase intratumoral accumulation and, in gemcitabine, standard therapy for pancreatic cancer. Applying the dosages schedule cancer, we performed phase II trial assess response rate nab-paclitaxel relapsed Ewing sarcoma.Using Simon's two-stage design identify ≥ 35%, received 125 mg/m2 followed by 1000 i.v. on days 1, 8, 15 four-week...
Success of clinical trials increasingly relies on effective selection the target patient populations. We hypothesize that computational analysis pre-accrual imaging data can be used for enrichment to better identify patients who potentially benefit from investigational agents.
Langerhans cell histiocytosis (LCH) may clinically manifest in a variety of ways due to its ability involve nearly every organ system. LCH present as single bone lesion, skin rash, or invasive disseminated disease and occurs typically the pediatric adolescent population, affecting both males females. Independent clinical presentation severity, lesions share common histology CD1a+/CD207+ dendritic cells along with an inflammatory infiltrate, and, based upon improved scientific understanding,...
ABSTRACT The current paradigm of clinical trials treating patients until disease progression using maximum tolerated dose does not account for the dynamic tumor-host-drug interactions that result in acquired resistance. Here, we present concept an Evolutionary Tumor Board (ETB) and report interim results from a prospective, non-interventional pilot study which novel therapeutic strategies based on evolutionary principles were developed under ETB framework. approach relies interdisciplinary...
Coffin-Siris syndrome (CSS) is a rare genetic condition associated with mutations in genes responsible for the modulation of gene expression and chromatin remodeling. Patients CSS commonly present congenital anomalies, intellectual disabilities, developmental delays. We describe case 28-year-old woman confirmed diagnosis SMARCB1 mutation who presents multiple schwannomas an intra-abdominal neurofibroma. The patient underwent embolization resection enlarging, symptomatic schwannoma her left...
Parachordoma is a rare entity with less than 50 cases described in the literature. This soft-tissue tumor resembles chordomas as well extraskeletal myxoid chondrosarcomas and has only recently been fully characterized. Here we describe case of patient lower back parachordoma its subsequent postresection recurrence 9 years after initial procedure, emphasizing importance long-term follow-up individuals this diagnosis.
We report a case of 25-year-old pregnant woman diagnosed with large, unresectable retroperitoneal synovial sarcoma. Successful neoadjuvant treatment doxorubicin plus ifosfamide prepartum and continuing postpartum resulted in significant disease response allowing for later tumor resection. Following the first chemotherapy cycle, decreased amniotic fluid index was noted, representing potential complication chemotherapy. Induction labor performed at 33 weeks gestation excellent outcome newborn....
We report a case of retropubic parasymphyseal cyst in 69-year-old multiparous female with protracted history metastatic small bowel carcinoid (neuroendocrine) tumor. Cysts related to the pubic symphysis are uncommon, and mostly reported subpubic location. They may be confused primary vulvar masses, malignant bone tumors or disease. In our case, encapsulation, lack solid components diffusion restriction, communication symphysis, activity on Gallium-68-Dotatate PET/CT signal characteristics...
TPS7594 Background: Phosphoinositide 3-kinase (PI3K) inhibitors have shown promising activity in lymphoid malignancies such as mature T cell lymphoma, diffuse large B and mantle lymphoma. Duvelisib’s PI3K-δ PI3K-γ lymphoma is a single agent (Horwitz, Koch et al. 2018). While the safety profile can generally be managed, certain autoimmune adverse events may limit its adaptation clinical practice. Azacitidine, pyrimidine nucleoside analog of cytidine, active (Saillard, Guermouche 2017) well...
Abstract Purpose Success of new cancer therapies relies strongly on effective selection the target patient populations. We hypothesize that computational analysis imaging data can be used for enrichment in clinical trials and hence aimed to establish appropriate framework this analysis. Methods This was tested among soft-tissue sarcoma (STS) patients accrued into a randomized trial (SARC021) evaluated efficacy evofosfamide (Evo), hypoxia activated prodrug, combination with doxorubicin (Dox)....
<p>SFigure 1: Histological examination of mouse lungs; SFigure 2: Tissue sections from human lung adenocarcinoma; 3: Cabozantinib (CBT) and vandetanib (VDT) resistant cells; 4: Comparison in vitro inhibition RET, RETV804L RETV804M by ponatinib, cabozantinib, vandetanib, lenvatinib; 5: Ponatinib treatment schedule body weight measurements; 6: Lung section histology Dox-induced C/KR mice treated with vehicle or ponatinib for 1 months; 7: μCT dox-induced tumors before after one month...
<p>Supplementary Methods, radiologist's reading of CT images, supplementary figure legends, references</p>
<p>microCT scans</p>
<div>Abstract<p><i>RET</i> fusions have been found in lung adenocarcinoma, of which <i>KIF5B–RET</i> is the most prevalent. We established inducible KIF5B-RET transgenic mice and KIF5B–RET-dependent cell lines for preclinical modeling <i>KIF5B–RET</i>-associated adenocarcinoma. Doxycycline-induced CCSP-rtTA/tetO-KIF5B-RET developed invasive adenocarcinoma with desmoplastic reaction. Tumors regressed upon suppression KIF5B–RET expression. By...
<div>Abstract<p><i>RET</i> fusions have been found in lung adenocarcinoma, of which <i>KIF5B–RET</i> is the most prevalent. We established inducible KIF5B-RET transgenic mice and KIF5B–RET-dependent cell lines for preclinical modeling <i>KIF5B–RET</i>-associated adenocarcinoma. Doxycycline-induced CCSP-rtTA/tetO-KIF5B-RET developed invasive adenocarcinoma with desmoplastic reaction. Tumors regressed upon suppression KIF5B–RET expression. By...