A5014285727- Lymphoma Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Lung Cancer Treatments and Mutations
- Medical Imaging Techniques and Applications
- Nutrition and Health in Aging
- Atmospheric Ozone and Climate
- Hernia repair and management
- COVID-19 Clinical Research Studies
- Viral-associated cancers and disorders
- CAR-T cell therapy research
- Shoulder Injury and Treatment
- Frailty in Older Adults
- Renal and related cancers
- COVID-19 and healthcare impacts
- Cardiac Arrhythmias and Treatments
- Chemotherapy-induced cardiotoxicity and mitigation
- Orthopedic Surgery and Rehabilitation
- SARS-CoV-2 and COVID-19 Research
- Sarcoma Diagnosis and Treatment
- Esophageal Cancer Research and Treatment
- Acute Lymphoblastic Leukemia research
- Atmospheric chemistry and aerosols
- Cardiac pacing and defibrillation studies
Düsseldorf University Hospital
2025
University Hospital Cologne
2025
University of Cologne
2025
Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases
2025
Heinrich Heine University Düsseldorf
2025
German Center for Infection Research
2025
Hospital Universitario Fundación Jiménez Díaz
2022-2024
Hospital Universitario Lucus Augusti
2013-2024
Moffitt Cancer Center
2016-2022
Universidad Autónoma de Madrid
2022
In this study we retrospectively evaluated the capability of computed tomography (CT)-based radiomic features to predict epidermal growth factor receptor (EGFR) mutation status in surgically-resected peripheral lung adenocarcinomas an Asian cohort patients.Two hundred ninety-eight patients with surgically resected were investigated institutional review board-approved retrospective requirement waived obtain informed consent. Two nineteen quantitative 3-D extracted from segmented volumes each...
Importance Peritoneal metastasis in patients with locally advanced colon cancer (T4 stage) is estimated to recur at a rate of approximately 25% 3 years from surgical resection and associated poor prognosis. There controversy regarding the clinical benefit prophylactic hyperthermic intraperitoneal chemotherapy (HIPEC) these patients. Objective To assess efficacy safety intraoperative HIPEC cancer. Design, Setting, Participants This open-label, phase randomized trial was conducted 17 Spanish...
Purpose To extract radiologic features from small pulmonary nodules (SPNs) that did not meet the original criteria for a positive screening test and identify associated with lung cancer risk by using data images National Lung Screening Trial (NLST). Materials Methods Radiologic in SPNs baseline low-dose computed tomography (CT) studies NLST to be considered examination were extracted. identified 73 incident case patients who given diagnosis of at either first or second follow-up study 157...
To investigate whether imaging features from pretreatment planning CT scans are associated with overall survival (OS), recurrence-free (RFS), and loco-regional (LR-RFS) after stereotactic body radiotherapy (SBRT) among nonsmall-cell lung cancer (NSCLC) patients.A total of 92 patients (median age: 73 yr) stage I or IIA NSCLC were qualified for this study. A dose 50 Gy in five fractions was the standard treatment. Besides clinical characteristics, 24 "semantic" image manually scored based on a...
Abstract Aims There is a lack of therapies able to prevent anthracycline cardiotoxicity (AC). Remote ischaemic conditioning (RIC) has shown beneficial effects in preclinical models AC. Methods REmote iSchemic condItioning Lymphoma PatIents REceiving ANthraCyclinEs (RESILIENCE) multinational, prospective, phase II, double‐blind, sham‐controlled, randomized clinical trial that evaluates the efficacy and safety RIC lymphoma patients receiving anthracyclines. Patients scheduled undergo ≥5...
This study investigated the sex-specific effects of commonly prescribed appetite suppressants on body weight and manifestation motor side effects, specifically stereotypy. Employing video recordings DeepLabCut (DLC) for precise behavioral quantification, we analyzed stereotypy, defined as purposeless, repetitive behaviors, in male female rats. Under control (saline) conditions, rats exhibited a greater propensity gain compared to females. However, contrast, demonstrated more homogenous loss...
To investigate the intersession reliability of selected kinematic and kinetic variables during countermovement vertical jumps (CMJs).Thirty-five men 35 women performed CMJs on a force platform four testing sessions each separated by 1 wk. Kinematic included time in air (TIA), take-off velocity (TOV), total displacement center mass (TJH), depth, whereas positive impulse, negative stiffness, rates development. Systematic bias was assessed calculating 90% confidence interval change mean between...
We describe Zika virus (ZIKV) vertical transmission in an imported case Spain, a 17-week pregnant woman. ZIKV IgG, IgM and RNA were detected serum week 17. At 19 weeks, ultrasound scan revealed fetal malformations was the amniotic fluid. Pregnancy terminated at 21; autopsy of fetus bilateral hydrocephalus, brain microcalcifications arthrogryposis multiplex congenita. umbilical cord tissue.
The purpose of this study was to investigate the potential computed tomography (CT) based radiomic features primary tumors predict pathological nodal involvement in clinically node-negative (N0) peripheral lung adenocarcinomas.A total 187 patients with clinical N0 adenocarcinomas who underwent preoperative CT scan and subsequently received systematic lymph node dissection were retrospectively reviewed. 219 quantitative 3D tumor extracted; meanwhile, nine radiological semantic evaluated....
We retrospectively evaluated the capability of radiomic features to predict tumor growth in lung cancer screening and compared performance multi-window single window features. One hundred fifty nodules among 114 screen-detected, incident patients from National Lung Screening Trial (NLST) were investigated. Volume double time (VDT) was calculated as difference between continuous two scans used define indolent aggressive cancers. semi-automatically segmented using mediastinal windows...
Success of clinical trials increasingly relies on effective selection the target patient populations. We hypothesize that computational analysis pre-accrual imaging data can be used for enrichment to better identify patients who potentially benefit from investigational agents.
To study the variability in volume change estimates of pulmonary nodules due to segmentation approaches used across several algorithms and evaluate these effects on ability predict nodule malignancy.We obtained 100 patient image datasets from National Lung Screening Trial (NLST) that had a detected each two consecutive low dose computed tomography (LDCT) scans, with an equal proportion malignant benign cases (50 malignant, 50 benign). Information about location for was provided by screen...
Aggressive B-cell lymphomas (ABCL) represent a heterogeneous group of biologically different diseases with variable clinical outcomes.1, 2 Around one-third patients are not cured frontline treatment, and outcomes for this relapse/refractory (R/R) extremely poor conventional treatments.3-5 However, during the last years, several promising new therapies (NTs) have been progressively incorporated into treatment arsenal, such as monoclonal antibodies (MAs), cellular therapy T cells chimeric...
Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin lymphoma. Despite notable therapeutic advances in last decades, 30%-40% affected patients develop relapsed or refractory disease that frequently precludes an infamous outcome. With advent new options, it becomes necessary to predict responses standard treatment based on rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP). In a recent communication, we presented machine learning model...
Abstract Background Electrophysiological studies and ablation procedures are the most prevalent activities in electrophysiology. However, device implantation represents a great deal of daily activity. In several European regions, aging populations becoming big concern, not only increasing number pacemakers implantations but also raising age threshold for implantation. Purpose Assessment survival rates after on patients over ninety years age. Are there any markers that could help us infer...