A5102022975- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Cardiac Imaging and Diagnostics
- Cardiac pacing and defibrillation studies
- Cardiovascular Function and Risk Factors
- Blood Pressure and Hypertension Studies
- Systemic Lupus Erythematosus Research
- Heart Failure Treatment and Management
- Muscle activation and electromyography studies
- Heart Rate Variability and Autonomic Control
- COVID-19 Clinical Research Studies
- Immune Cell Function and Interaction
- Thermoregulation and physiological responses
- Cardiac electrophysiology and arrhythmias
- Lung Cancer Research Studies
- Lung Cancer Diagnosis and Treatment
- Viral Infections and Immunology Research
- Climate Change and Health Impacts
- Monoclonal and Polyclonal Antibodies Research
- Lung Cancer Treatments and Mutations
- Complementary and Alternative Medicine Studies
- Hydrology and Watershed Management Studies
- Gastric Cancer Management and Outcomes
- Liver Disease Diagnosis and Treatment
- Cytokine Signaling Pathways and Interactions
University of Oklahoma Health Sciences Center
2016-2024
XinHua Hospital
2015-2023
Shanghai Jiao Tong University
2012-2023
Affiliated Hospital of Jiangsu University
2023
Xuzhou Cancer Hospital
2023
Shanxi Medical University
2023
Xuzhou Central Hospital
2022-2023
Soochow University
2023
First Affiliated Hospital of Soochow University
2023
Jiangsu University
2023
In a community-based study, the relationship between age and human prostate size was investigated in population of men ages 40 70 years to determine normal increase curve equation.One thousand male volunteers were randomly recruited from Shanghai community, length, width, height, volume transition zone (TZ) whole prostates measured by transrectal ultrasound (TRUS).Each volunteer evaluated International Prostate Symptom Score (IPSS).Among those who completed examination, mean parameters all...
Recent data demonstrate promising effects on left ventricular dysfunction and ejection fraction (LVEF) improvement following ablation for atrial fibrillation (AF) in patients with heart failure. We sought to study the relationship between LVEF, New York Heart Association class presentation, end points of mortality failure admissions CASTLE-AF (Catheter Ablation Atrial Fibrillation With Failure) population. Furthermore, predictors LVEF were examined.The coexisting AF (n=363) randomized a...
To explore the relationship between extent of central nervous system (CNS) injury and patient outcomes meanwhile research potential risk factors associated with neurologic sequelae. In this retrospective cohort study, we analyzed data from 117 consecutive patients (86 survivors, 31 nonsurvivors) exertional heat stroke (EHS) who had been admitted to intensive care unit (ICU) at 48 Chinese hospitals April 2003 July 2015. Extent CNS was dichotomized according Glasgow coma scale (GCS) score...
Myocarditis leads to dilated cardiomyopathy (DCM) with one-third failing recover normal ejection fraction (EF 50%). Our previous studies have supported a Th17 autoimmune pathogenesis where IL17A and IL-6 are elevated in myocarditis patients who do not EF. In the non-recovered group, autoantibody mechanisms of myocardial injury systolic dysfunction fully understood. Furthermore, our cohort, cardiac myosin (CM) autoantibodies (AAbs) were cross-reactive β−adrenergic receptor (βAR). Here we...
Abstract Background Heat stroke (HS) is a serious, life-threatening disease. However, there no scoring system for HS so far. This research to establish that can quantitatively assess the severity of exertional heat (EHS). Methods Data were collected from total 170 (EHS) patients between 2005 and 2016 52 hospitals in China. Univariate statistical methods comparison area under receiver operating characteristic (ROC) curve (AUC) used screen score (EHSS) parameters, including but not limited...
Antecedent group A streptococcal pharyngitis is a well-established cause of acute rheumatic fever (ARF) where valvular heart disease (RHD) and Sydenham chorea (SC) are major manifestations. In ARF, crossreactive antibodies T cells respond to antigens, carbohydrate, N-acetyl-β-D-glucosamine (GlcNAc), M protein, respectively, through molecular mimicry target brain tissues. this translational human study, we further address our hypothesis regarding specific pathogenic humoral cellular immune...
This article deals with clinical trials a sensitive subpopulation of patients, that is, subgroup is more likely to benefit from the treatment than overall population. Given defined by prespecified classifier, for example, marker or pharmacogenomic marker, trial’s outcome declared positive if effect established in population subgroup. We provide summary key considerations subgroup, including multiplicity and enrichment adjustments as well optimality analysis strategy. The methodology proposed...
// Janani Panneerselvam 1, 4 , Akhil Srivastava Ranganayaki Muralidharan Qi Wang Wei Zheng 1 Lichao Zhao Alshine Chen 3, Yan D. Anupama Munshi 2, Rajagopal Ramesh 4, 5 Department of Pathology, The University Oklahoma Health Sciences Center, City, 73104, USA 2 Radiation Oncology, 3 Biostatistics and Epidemiology, Stephenson Cancer Graduate Program in Biomedical Sciences, Correspondence to: Ramesh, email: rajagopal-ramesh@ouhsc.edu Keywords: IL-24, lung cancer, HMGA1, miR222-3p, metastasis...
Abstract Background Catheter ablation is effective in restoring sinus rhythm and left atrial appendage closure (LAAC) increasingly used for stroke prevention patients with fibrillation (AF). We aimed to observe the feasibility safety of performing AF LAAC a single (one-stop) procedure. Methods Consecutive who underwent combined procedure WATCHMAN device between March 2017 September 2018 were prospectively enrolled. Baseline intra-procedural parameters evaluated. Three-month subsequent 1-year...
Heart failure (HF) remains a major public health problem with increasing prevalence in China. This study evaluated the clinical performance and quality measures for HF management to identify gaps standardization of care patients hospitalized
To explore the value of detecting peri-device leak (PDL) and device endothelialization after left atrial appendage closure (LAAC) by cardiac computed tomography (CT) in patients with fibrillation (AF), who underwent Watchman LAAC combined radiofrequency ablation (AFCA).Patients symptomatic drug-refractory at high risk stroke (CHA2 DS2 -VASc Score ≥ 2), AFCA our center from March 2017 to December 2018 were enrolled. Maximum diameter LAA orifice was determined preoperative CCTA. A standardized...
Objective:To evaluate short- and long-term safety efficacy of duloxetine in women with predominant stress urinary incontinence (SUI).Research design methods:The study was a 6-week, double-blind, randomised, parallel, placebo-controlled followed by an uncontrolled open-label extension (OLE) run 342 centres 16 European countries. Women SUI were randomly assigned to placebo (n = 1380) or 40 mg twice daily 1378) for 6 weeks. Completers the acute phase enrolled OLE, which had minimum duration...
Abstract: Treatment of myocardial infarction (MI) with adipose-derived stem cells (ASCs) has produced promising results. Cyclosporine A (CsA) inhibits apoptosis by preventing the opening mitochondrial permeability transition pores. CsA nanoparticle emulsion (CsA-NP) lower toxicity and higher efficiency as compared to CsA. In this study, we hypothesized that a combination ASCs CsA-NP would enhance therapeutic in swine MI model. was induced pig hearts occlusion left anterior descending artery....
Introduction Chronic kidney disease (CKD) is a progressive with high incidence but early imperceptible symptoms. Since China’s rural areas are subject to inadequate medical check-ups and single screening programme, it could easily translate into end-stage renal failure. This study aimed construct an warning model for CKD tailored impoverished by employing machine learning (ML) algorithms accessible parameters from ten in Shanxi Province, thereby, promoting forward shift of treatment time...
Objective To test the hypothesis that some lupus anticoagulants are antiprothrombin antibodies, and such antibodies enhance prothrombin binding to endothelial cells (EC) thus promote clotting on cell surface. Methods We generated a monoclonal antibody (designated IS6) from patient with primary antiphospholipid syndrome (APS). The was analyzed for its properties, anticoagulant activity, pathophysiologic using an EC-based plasma coagulation assay. Results IS6 is first patient-derived IgG...