A5070821311- Cholesterol and Lipid Metabolism
- Adipose Tissue and Metabolism
- Sodium Intake and Health
- Liver Disease Diagnosis and Treatment
- Diet and metabolism studies
- Steroid Chemistry and Biochemistry
- Peroxisome Proliferator-Activated Receptors
- Advanced Glycation End Products research
- Muscle metabolism and nutrition
- Dietary Effects on Health
- Atherosclerosis and Cardiovascular Diseases
- Nutritional Studies and Diet
- Sphingolipid Metabolism and Signaling
- Fatty Acid Research and Health
- Antioxidant Activity and Oxidative Stress
- Hormonal Regulation and Hypertension
- Obesity, Physical Activity, Diet
- Sports Performance and Training
- Immune Response and Inflammation
- Cancer, Lipids, and Metabolism
- Consumer Attitudes and Food Labeling
- Immune cells in cancer
- Healthcare Regulation
- Graphene and Nanomaterials Applications
- Estrogen and related hormone effects
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2017-2024
Samsung (Brazil)
2024
Universidade Federal do ABC
2023
Universidade de São Paulo
2015-2020
In humans, aging, triggers increased plasma concentrations of triglycerides, cholesterol, low-density lipoproteins and lower capacity high-density to remove cellular cholesterol. Studies in rodents showed that aging led cholesterol accumulation the liver decrease brain with reduced synthesis levels 24-hydroxylase, an enzyme responsible for removing from brain. Liver diseases are also related inducing changes metabolism rats. It has been suggested late onset Alzheimer's disease is associated...
Advanced glycation end products (AGEs) prime macrophages for lipopolysaccharide (LPS)-induced inflammation. We investigated the persistence of cellular AGE-sensitization to LPS, considering nuclear content p50 and p65 factor kappa B (NFKB) subunits expression inflammatory genes. Macrophages treated with control (C) or AGE-albumin were rested varying intervals in medium alone before being incubated LPS. Comparisons made using one-way ANOVA Student t-test (n = 6). primed increased...
Regular exercise prevents and regresses atherosclerosis by improving lipid metabolism antioxidant defenses. Exercise ameliorates the reverse cholesterol transport (RCT), an antiatherogenic system that drives from arterial macrophages to liver for excretion into bile feces. In this study we analyzed role of aerobic on in vivo RCT expression genes proteins involved flux inflammation peritoneal macrophages, aortic arch wild type mice. Twelve-week-old male mice were divided sedentary trained...
Advanced glycation end products (AGEs) are independently related to cardiovascular disease (CVD) and favor cholesterol oxysterol accumulation in macrophage foam cells. Soluble RAGE (sRAGE) impairs cellular AGE signaling alleviating the deleterious effects of atherogenesis. The association between plasma AGEs sRAGE with content cholesterol, markers synthesis absorption, oxysterols atherosclerotic plaques was evaluated subjects undergoing carotid endarterectomy.Plasma were obtained from...
Background: Oxysterols are bioactive lipids that control cellular cholesterol synthesis, uptake, and exportation besides mediating inflammation cytotoxicity modulate the development of atherosclerosis. Aerobic exercise training (AET) prevents regresses atherosclerosis by improvement lipid metabolism, reverse transport (RCT) antioxidant defenses in arterial wall. We investigated dyslipidemic mice role a 6-week AET program content plasma aortic arch oxysterols, expression genes related to flux...
Experimental and clinical studies have demonstrated the effect of phytosterols (PS) on reducing plasma levels cholesterol LDL-c, but effects plant sterols beyond cholesterol-lowering are still questionable. Since inflammation endothelial dysfunction involved in pathogenesis atherosclerosis, this study aims to evaluate PS biomarkers atherosclerosis progression whether these independent alterations LDL-c levels. Thirty-eight moderately hypercholesterolemic volunteers (58 ± 12 years; ≥ 130...
Dietary sodium restriction increases plasma triglycerides (TG) and total cholesterol (TC) concentrations as well causing insulin resistance stimulation of the renin-angiotensin-aldosterone system (RAAS) sympathetic nervous system. Stimulation angiotensin II type-1 receptor (AT1) is associated with resistance, inflammation, inhibition adipogenesis. The current study investigated whether aerobic exercise training (AET) mitigates or inhibits adverse effects dietary on adiposity, sensitivity in...
Because the plasma campesterol/cholesterol ratio does not differ between groups that absorb different amounts of cholesterol, authors investigated whether Phytosterols (PS) relate to body's cholesterol synthesis rate measured as non-cholesterol sterol precursors (lathosterol). The studied 38 non-obese volunteers (58±12 years; Low-Density Lipoprotein Cholesterol ‒ LDL-C ≥ 130 mg/dL) randomly assigned consume 400 mL/day soy milk (Control phase) or + PS (1.6 g/day) for four weeks in a...
Aerobic exercise training (AET) improves the reverse cholesterol transport (RCT) in cholesteryl ester transfer protein-transgenic (CETP-tg) mice. We aimed at investigating role of AET expression genes and proteins involved lipid flux aorta macrophages CETP-tg Three-month-old male mice were randomly divided into trained (T; treadmill 15 m/min; 30 min/day) sedentary (S) groups. After 6 weeks, peritoneal aortic arch obtained immediately (0h) or 48 h after last session. mRNA was determined by...
Background: A low-sodium (LS) diet reduces blood pressure, contributing to the prevention of cardiovascular diseases. However, intense dietary sodium restriction impairs insulin sensitivity and worsens lipid profile. Considering benefits aerobic exercise training (AET), effect LS AET in hepatic content gene expression was investigated LDL receptor knockout (LDLr-KO) mice. Methods: Twelve-week-old male LDLr-KO mice fed a normal (NS) or were kept sedentary (S) trained (T) for 90 days. Body...
A low-sodium (LS) diet has been shown to reduce blood pressure (BP) and the incidence of cardiovascular diseases. However, severe dietary sodium restriction promotes insulin resistance (IR) dyslipidemia in animal models humans. Thus, further clarification long-term consequences LS is needed. Here, we investigated effects chronic on gastrocnemius gene protein expression lipidomics its association with IR plasma lipids LDL receptor knockout mice. Three-month-old male mice were fed a normal...
Non-cholesterol sterols are transported in plasma lipoproteins and consequently important cholesterol metabolism. We investigated the distribution of non-cholesterol sterol precursors synthesis (NCSPCS), oxysterols, phytosterols healthy subjects differing according to HDL-Cholesterol (HDL-C) levels. Elevated NCSPCS (desmosterol, lathosterol) High HDL group suggests that exports these from cells, but not metabolite 24-OHC which was higher Low than group. 27-hydroxycholesterol (27OH-C) levels...
The association between lipoprotein levels and late-onset neonatal sepsis has shown controversial results. aims are to assess lipid profile, cytokines, Monocyte-to-HDL (M/H) ratio as diagnostic prognostic markers for sepsis. This prospective study included 49 septic neonates 17 controls. Cholesterol (CT), Triglyceride (TG), Very-Low-Density (VLDLc), Low-Density (LDLc), High-Density Lipoproteins (HDLc) were measured at admission (D0) on days 3, 7 10 evaluate shock outcomes. Cytokines...
Abstract Background This study investigated the safety, reactogenicity, and immunogenicity in healthy subjects of a Clostridioides difficile vaccine candidate with/without adjuvant, targeting toxins A B. Methods In this first-in-human, phase 1, observer-blind study, aged 18–45 years were randomized to receive F2 antigen (n = 10) or placebo 10), 50–70 plus AS01 adjuvant 45), 30) 2 doses 1 month apart. subcohort 40) received third dose 15 months later. Solicited adverse events (AEs) recorded...
<title>Abstract</title> Obstructive sleep apnea (OSA) is a prevalent condition that frequently goes undiagnosed. NoSAS Score provides straightforward approach for rapid and accurate OSA screening, although it requires measuring neck circumference (NC). We aimed to develop linear regression model estimate NC using variables. 3,109 subjects from the Sleep Health Heart Study database were included (56% man; 62 ± 10 years; body mass index [BMI] = 28.6 4.8 kg/m2; 38.5 cm; apnea-hypopnea 14.5)....
This study investigated the efficacy of aerobic exercise training (AET) in prevention dyslipidemia, insulin resistance (IR), and atherogenesis induced by severe low-sodium (LS) diet. LDL receptor knockout (LDLR KO) mice were fed a (0.15% NaCl) or normal-sodium (NS; 1.27% diet, submitted to AET treadmill, 5 times/week, 60 min/day, 15 m/min, for 90 days, kept sedentary. Blood pressure (BP), plasma total cholesterol (TC) triglyceride (TG) concentrations, lipoprotein profile, sensitivity...