A5044741991- SARS-CoV-2 detection and testing
- SARS-CoV-2 and COVID-19 Research
- Biosensors and Analytical Detection
- biodegradable polymer synthesis and properties
- Nanoparticles: synthesis and applications
- Chronic Obstructive Pulmonary Disease (COPD) Research
- COVID-19 diagnosis using AI
- Pulmonary Hypertension Research and Treatments
- Neonatal Respiratory Health Research
- Antimicrobial agents and applications
- Peptidase Inhibition and Analysis
- Additive Manufacturing and 3D Printing Technologies
- Infection Control and Ventilation
- Graphene and Nanomaterials Applications
- Public Health and Environmental Issues
- Education and Public Policy
- Skin Protection and Aging
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Agricultural pest management studies
- Maternal and Neonatal Healthcare
- Dental Research and COVID-19
- Inhalation and Respiratory Drug Delivery
- Water Quality Monitoring Technologies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Asthma and respiratory diseases
Universidade Federal do ABC
2014-2023
Natura (Brazil)
2018
Environmental Protection Agency
1995
The SARS-CoV-2 virus, the etiological agent of COVID-19, affected millions people and caused major public health impacts. With detection viral RNA feces infected individuals, several countries adopted wastewater-based epidemiology to track its circulation. However, most studies focused on large urban centers. This study analyzed presence persistence in wastewater from two small Brazilian towns with low socioeconomic indices, located northern Minas Gerais, during after pandemic. Wastewater...
Aims To determine whether a serine protease inhibitor treatment can prevent or minimize emphysema in mice. Methods C57BL/6 mice were subjected to porcine pancreatic elastase (PPE) nasal instillation induce and treated with (rBmTI-A) before (Protocol 1) after 2) development. In both protocols, we evaluated lung function evaluate the airway resistance (Raw), tissue damping (Gtis) elastance (Htis). The inflammatory profile was analyzed bronchoalveolar lavage (BALF) through use of morphometry;...
The successful development of multifunctional cotton fabrics with antimicrobial and antiviral activities is essential to prevent the proliferation microorganisms transmission coronavirus virions today, especially emergence new variants SARS-CoV-2. In this work, we developed Ag/TiO2 nanoparticles synthesized via sonochemistry. Here, show that more than 50% infectious SARS-CoV-2 remain active after prolonged direct contact self-disinfecting materials capable inhibiting Escherichia coli...
Bioinspired bactericidal surfaces are artificial that mimic the nanotopography of insect wings and capable inhibiting microbial growth by a physicomechanical mechanism. The scientific community has considered them an alternative method to design polymers with inhibit bacterial biofilm formation, suitable for self-disinfectant medical devices. In this contribution, poly(lactic acid) (PLA) nanocone patterns was successfully produced novel two-step procedure involving copper plasma deposition...
Smoking is the main risk factor for chronic obstructive pulmonary disease development and cigarette smoke (CS) exposure considered an important approach to reproduce in rodents this human disease. We have previously shown that elastase-induced model of emphysema, administration a protease inhibitor (rBmTI-A) prevented attenuated tissue destruction mice. Thus, study we aimed verify effects rBmTI-A on physiopathological mechanisms CS-induced emphysema.Mice (C57BL/6) were exposed CS or room air...
To evaluate whether a recombinant serine protease inhibitor (rBmTI-A) modulates inflammation in an experimental model of chronic allergic lung inflammation. Balb/c mice were divided into four groups: SAL (saline), OVA (sensitized with ovalbumin), + rBmTI-A (control treated rBmTI-A) and ovalbumin rBmTI-A). The animals received intraperitoneal injection saline or ovalbumin, according to the group. groups inhalation by nasal instillation. After 29 days, we evaluated respiratory mechanics;...
Protease/anti-protease imbalance is the main pathogenic mechanism of emphysema and protease inhibitors have been recognized as potential molecules to treat disease conditions. In this work rBmTI-6 first domain (rBmTI-6-D1), a recombinant Kunitz-type serine proteinase inhibitor, was used verify its effect in prevention or minimization PPE-induced mice. C57BL/6 mice were submitted model treated with rBmTI-6-D1 before development. We showed that treatment sufficient avoid loss elastic recoil,...
Serine proteases and its inhibitors are involved in physiological process deregulation lead to various diseases like Chronic Obstructive Pulmonary Disease (COPD), pulmonary emphysema, skin diseases, atherosclerosis, coagulation cancer, inflammatory neuronal disorders other diseases. protease have been described many species, as well plants, including cowpea beans (Vigna unguiculata (L.) Walp). Here, we purified characterized a inhibitor, named VuEI elastase inhibitor), from Vigna...
ABSTRACT rBmTI-A is a recombinant serine protease inhibitor that belongs to the Kunitz-BPTI family and was cloned from Rhipicephalus microplus tick. has inhibitory activities on bovine trypsin, human plasma kallikrein, neutrophil elastase plasmin with dissociation constants in nM range. It characterized by two domains each domain presents six cysteines form three disulfide bonds, which contribute high stability of its structure. Previous studies suggest protective potential against pulmonary...