A5005077485- Atherosclerosis and Cardiovascular Diseases
- Immune Cell Function and Interaction
- Antioxidant Activity and Oxidative Stress
- Research on Leishmaniasis Studies
- Lipoproteins and Cardiovascular Health
- Adipokines, Inflammation, and Metabolic Diseases
- T-cell and B-cell Immunology
- HIV-related health complications and treatments
- Systemic Lupus Erythematosus Research
- HIV Research and Treatment
- Immune Response and Inflammation
- Cholesterol and Lipid Metabolism
- Trypanosoma species research and implications
- Fatty Acid Research and Health
- Lanthanide and Transition Metal Complexes
- Monoclonal and Polyclonal Antibodies Research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cancer, Lipids, and Metabolism
- T-cell and Retrovirus Studies
- Cardiovascular Disease and Adiposity
- Cerebrovascular and Carotid Artery Diseases
- Chronic Lymphocytic Leukemia Research
- Protein Interaction Studies and Fluorescence Analysis
- Paraoxonase enzyme and polymorphisms
- Lipid metabolism and disorders
Universidade de São Paulo
2016-2025
Institute of Biomedical Science
2023-2025
Hospital Universitário da Universidade de São Paulo
2024
Universidade Federal de São Paulo
2015
Universidade Brasil
2000-2014
Karolinska Institutet
1989-2011
Skåne University Hospital
2011
Lund University
2011
University of Gothenburg
2011
Karolinska University Hospital
2011
OxLDL is recognized by macrophage scavenger receptors, including CD36; we have recently found that Platelet-Activating Factor Receptor (PAFR) also involved. Since PAFR in macrophages associated with suppressor function, examined the effect of oxLDL on phenotype. It was presence during differentiation induced high mRNA levels to IL-10, mannose receptor, PPAR γ and arginase-1 low IL-12 iNOS. When human THP-1 were pre-treated then stimulated LPS, production IL-10 TGF- β significantly increased,...
Hypercholesterolemia is a major risk factor for development of atherosclerosis. In experimental animals fed high-cholesterol diet, monocytes adhere to the arterial endothelium and penetrate into intima where they differentiate macrophages ingest lipids thus giving rise fatty streaks, earliest type atherosclerotic plaque. Macrophages express few receptors normal low density lipoprotein (LDL) but can take up oxidized LDL by way scavenger receptor. The present study was designed investigate...
A malignant glioma cell line was infected with the human T-lymphotropic virus type IIIB isolate of immunodeficiency virus. Infection appeared to be latent rather than productive. Through contact monocytic or lymphoid cells, present in cells could transmitted and gave rise a fully productive infection.
Background: Recently, there has been an increasing in the impact of oral health on atherosclerosis and subsequent cardiovascular disease. The aim this study is to investigate association between chronic periodontitis risk markers. Methods: Forty patients with 40 healthy gender‐, body mass index–, age‐matched individuals were compared by measuring total cholesterol, high‐density lipoprotein, low‐density triglycerides, levels cytokines, antibodies against oxidized thiobarbituric acid reactive...
Induction of differentiation the human monoblastic cell line U-937 in vitro by several physiologic and nonphysiologic inducers is accompanied a rapid decrease expression MYC, endogenous myc protooncogene. To investigate whether this reduction prerequisite for terminal differentiation, we introduced constitutively expressed v-myc gene into cells. The results show that constitutive an avian oncogene does not interfere with phorbol 12-myristate 13-acetate-induced cells early after stimulation....
Abstract Natural killer (NK) cells in normal mouse spleen have so far been found to lack conventional cell surface markers. Recently, neuraminidase treatment has shown uncover receptors for the A hemagglutinin of snail Helix pomatia (HP) on populations (preferentially T cells) human blood lymphocytes. We used HP coupled Sepharose columns fractionate cells. Fractions consisted passed (fraction I) and eluted with competitive hapten N‐acetyl‐ D ‐galactosamine at either 0.1 mg/ml II) or 1.0...
Subendothelial deposited low-density lipoprotein particles are a known inflammatory factor in atherosclerosis. However, the causal components derived from still poorly defined. Apolipoprotein B100 (ApoB100) is unexchangeable protein component of lipoprotein, and progression atherosclerosis associated with immune responses to ApoB100-derived peptides. In this study, we analyzed proinflammatory activity ApoB100 peptides atherosclerosis.By screening peptide library ApoB100, identified distinct...
Reduced estrogen levels result in loss of protection from coronary heart disease postmenopausal women. Enhanced and diminished atherosclerosis have been associated with plasma cholesteryl ester transfer protein (CETP); however, little is known about the role CETP-ovarian hormone interactions atherogenesis. We assessed severity diet-induced ovariectomized (OV) CETP transgenic mice crossbred LDL receptor knockout mice. Compared OV expressing (+), non-expressing (−) had higher total, VLDL-,...
Abstract The possible in vivo relevance of murine natural killer (NK) cells resistance towards grafted lymphoma was analyzed. system comprised two AKR T lymphomas having similar behavior as to growth patterns but significant differences vitro with regard susceptibility NK‐cell‐mediated lysis. These tumor were into (AKRxCBA)F 1 hybrids which had been lethally irradiated and then protected bone marrow CBA or origin. Some adult animals thymectomized before irradiation. F chimeras could be shown...
AbstractInsulin like growth factor (IGF) 1 and 2 which are present actively synthesised in the wound fluid stimulate several cell types involved process of healing. To investigate role IGF-1 addition, association between IGF their carrier proteins, binding proteins (IGFBP), we have used a newly established model for human healing fresh biopsy material. Histological examination shows that stimulates efficient reepithelialisation wounds both alone presence recombinant IGFBP-1. In contrast,...
In this work, design and physiochemical characterization of a biocompatible nanoplatform with integrated photoluminescence magnetic properties were reported. The potential in vivo toxicity was assessed by exploring the biodistribution nanoparticles using synchrotron X-ray fluorescence (SXRF) imaging zebrafish embryos as biological model. Their synthesis is accessible through combining iron oxide Ce3+- Tb3+-doped GdOF luminophore concurrent capping situ chitosan biopolymer....