A5069361537- Mitochondrial Function and Pathology
- Thyroid Cancer Diagnosis and Treatment
- Metabolism and Genetic Disorders
- X-ray Diffraction in Crystallography
- Advanced Drug Delivery Systems
- Crystallization and Solubility Studies
- Metabolomics and Mass Spectrometry Studies
- Advanced biosensing and bioanalysis techniques
- Estrogen and related hormone effects
- RNA Interference and Gene Delivery
- Diphtheria, Corynebacterium, and Tetanus
- Cancer-related Molecular Pathways
- Cancer, Lipids, and Metabolism
- Adipose Tissue and Metabolism
- Bacterial Identification and Susceptibility Testing
- Cancer, Stress, Anesthesia, and Immune Response
- Dermatoglyphics and Human Traits
- Diet, Metabolism, and Disease
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Streptococcal Infections and Treatments
- Telomeres, Telomerase, and Senescence
- Effects of Radiation Exposure
- Organometallic Compounds Synthesis and Characterization
- Lipoproteins and Cardiovascular Health
- Microbial Inactivation Methods
Namık Kemal University
2009-2023
Marmara University
1998-2011
Adli Tıp Kurumu
2007
Recently, efforts have been focused on mitochondrial DNA changes and their relation to human cancers. Among them, a 4977 bp deletion of DNA, named "common deletion", has investigated in several types tumors, with inconsistent results. In this study, we the presence common tissues from 25 breast, colorectal 50 thyroid tumors adjacent healthy Turkish patients. Samples volunteers were also evaluated for comparison. Two PCR-based methods used detection deletion. First, two pairs primers amplify...
The new binuclear antimony(III) complexes corresponding to the formulas [SbCl3(µ2-S)(MtMBZIM)2]2 (1), {[SbBr2(µ2-Br)(MtMBZIM)2]2·H2O} (2) and {[SbI2(µ2-I)(MtMBZIM)2]2·H2O} (3) (MtMBZIM: 5-methoxy-2-mercaptobenzimidazole) have been synthesized structurally characterized with regard their melting point, elemental analysis, molar conductivity, FT-IR, FT-Raman spectroscopic techniques, TG-DTA analysis. crystal structures of 1-3 determined by single-crystal X-ray diffraction. Compounds are doubly...
As the knowledge base and importance of mitochondrial physiology to human health expands, necessity for harmonizing terminologyconcerning respiratory states rates has become increasingly apparent. Thechemiosmotic theoryestablishes mechanism energy transformationandcoupling in oxidative phosphorylation. Theunifying concept protonmotive force providestheframeworkfordeveloping a consistent theoretical foundation ofmitochondrial bioenergetics.We followguidelines International Union Pure Applied...
To investigate the protective effect of immune-enhanced diet (IED) on chemoradiation-induced injury gastrointestinal mucosa.Forty-eight Sprague-Dawley rats were divided into control (C, n=6), irradiation (IR, n=14), fluoropyrimidine (5-FU, n=14)-treated, IR + 5-FU (n=14)-treated groups. Half each irradiated and/or 5-FU-treated groups previously fed with IED containing arginine, omega-3-fatty acids and RNA fragments, while other half a standard rat (SD) for eight days before induction or...
LETM1 is a mitochondrial inner-membrane protein, which encoded by gene present in locus of 4p, which, turn, deleted the Wolf-Hirschhorn Syndrome, and assumed to be related its pathogenesis. The cellular damage caused deletion presumably oxidative stress. Melatonin has many beneficial roles protecting mitochondria scavenging reactive oxygen species, maintaining membrane potential, improving functions. aim this study was investigate effects melatonin administration LETM1-silenced mouse...
Abstract Background Mutations in the mitochondrial DNA (mtDNA) have been reported a wide variety of human neoplasms. A polynucleotide tract extending from 303 to 315 nucleotide positions (D310) within non-coding region mtDNA has identified as mutational hotspot primary tumors. This consists two polycytosine stretches interrupted by thymidine nucleotide. The number cytosines at first and second are 7 5 respectively, according GeneBank sequence. stretch exhibits polymorphic length variation...
Acid phosphatase locus 1 (ACP1) encodes a polymorphic enzyme and has potential implications for the development of metabolic syndrome (MS) by altering insulin sensitivity. The aim this study was to determine whether relationship exists between ACP1 genotypes various risk factors. Materials methods: We employed PCR-RFLP based genotyping in cohort 70 patients with MS 168 healthy individuals. Results: When compared controls, associated low activity were observed at significantly lower...
Mitokondriyal DNA' nin, nukleer ya kiyasla mutasyonlara daha duyarli olmasi ve tamir mekanizmalarinin sinirliligi nedeniyle karsinogenezde rol aldigi one surulmustur. Bu derlemede tiroid, kolorektal, meme gastrik kanserlerde, mitokondriyal genom kararsizligi, DNA mutasyonlarinin apoptozis ile iliskisi genomdaki degisimler degerlendirilmistir. Anahtar Kelimeler: DNA, Genomik kararsizlik, Apoptozis, Mutasyon, Solid tumorler
Abstract Background It is currently present in the literature that mitochondrial DNA (mtDNA) defects are associated with a great number of diseases including cancers. The role variations development thyroid cancer highly controversial topic. In this study, we investigated mt-DNA control region (CR) tumor progression and influence mtDNA haplogroups on susceptibility to tumors. Material & method For purpose, totally 108 hot nodules (HTNs), 95 cold (CTNs), 48 papillary carcinoma (PTC)...
Abstract The literature suggests that mitochondrial DNA (mtDNA) defects are associated with a large number of diseases including cancers. role mtDNA variations in thyroid cancer is highly controversial topic. Therefore, we investigated the mt-DNA control region (CR) tumor progression and influence haplogroups on susceptibility to tumors. For this purpose, total, 108 hot nodules (HTNs), 95 cold (CTNs), 48 papillary carcinoma (PTC) samples their surrounding tissues 104 healthy subjects’ blood...
Abstract Background and Aims: Glucocorticoid receptor (GR) has been postulated to serve an important role in normal breast carcinoma. On the other hand, studies on its common polymorphisms with cancer are very limited. In this study, we aimed assess presence frequency of 4 GR gene cancerous tissue samples from patients Turkish population compare them healthy individuals. Methods: DNA 86 female controls analysed for BclI, Tth111I, N363S ER22/23EK by PCR-RFLP. Results: polymorphism was not...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)