A5039349687- Antimicrobial Peptides and Activities
- SARS-CoV-2 and COVID-19 Research
- Fungal Infections and Studies
- Cancer Mechanisms and Therapy
- Biochemical and Structural Characterization
- Peptidase Inhibition and Analysis
- Chronic Myeloid Leukemia Treatments
- Protein Hydrolysis and Bioactive Peptides
- Viral gastroenteritis research and epidemiology
- Antifungal resistance and susceptibility
- Phytochemical compounds biological activities
- Cancer-related gene regulation
- Lung Cancer Treatments and Mutations
- Ferroptosis and cancer prognosis
- Colorectal Cancer Treatments and Studies
- Chronic Lymphocytic Leukemia Research
- Probiotics and Fermented Foods
- COVID-19 Clinical Research Studies
- Acute Lymphoblastic Leukemia research
- Transgenic Plants and Applications
- Antimicrobial agents and applications
- Melanoma and MAPK Pathways
- Animal Virus Infections Studies
- Plant-Microbe Interactions and Immunity
- Toxin Mechanisms and Immunotoxins
Universidade Federal do Ceará
2018-2025
Fundação Centro de Hematologia e Hemoterapia de Minas Gerais
2023-2024
Unichristus
2023
PharmacoGenetics (China)
2022
Universidade Federal do Pará
2014-2018
Abstract Living cells are constantly exchanging momentum with their surroundings. So far, there is no consensus regarding how respond to such external stimuli, although it reveals much about internal structures, motility as well the emergence of disorders. Here, we report that twelve cell lines, ranging from healthy fibroblasts cancer cells, hold a ubiquitous double power-law viscoelastic relaxation compatible fractional Kelvin-Voigt model. Atomic Force Microscopy measurements in time domain...
Gastric cancer (GC) remains the third leading cause of cancer-related death despite several improvements in targeted therapy. There is therefore an urgent need to investigate new treatment strategies, including identification novel biomarkers for patient stratification. In this study, we evaluated effect FDA-approved kinase inhibitors on GC. Through a combination cell growth, migration and invasion assays, identified dasatinib as efficient inhibitor GC proliferation. Mass-spectrometry-based...
Cryptococcus neoformans is a human-pathogenic yeast responsible for pneumonia and meningitis, mainly in patients immunocompromised. Infections caused by C. are global health concern. Synthetic antimicrobial peptides (SAMPs) have emerged as alternative molecules to cope with fungal infections, including neoformans. Here, eight SAMPs were tested regarding their antifungal potential against had mechanisms of action elucidated fluorescence scanning electron microscopies. Five showed an...
Abstract Aurora kinases (AURKA and AURKB) are mitotic with an important role in the regulation of several events, hematological malignancies, AURKA AURKB hyperexpression found patients cytogenetic abnormalities presenting a unfavorable prognosis. The aim this study was evaluated mRNA expression profile pediatric Acute Lymphoblastic Leukaemia (ALL) efficacy two designed inhibitors (GW809897X GW806742X) leukemia cell line as potential novel therapy for ALL patients. Cellular experiments...
The outbreak caused by SARS-CoV-2 has taken many lives worldwide. Although vaccination started, the development of drugs to either alleviate or abolish symptoms COVID-19 is still necessary. Here, four synthetic peptides were assayed regarding their ability protect Vero E6 cells from infection and toxicity human zebrafish embryos. All had some with D614G mutation. Molecular docking predicted all interact induce conformational alterations in spike protein containing PepKAA was most effective...
C. albicans and parapsilosis are biofilm-forming yeasts responsible for bloodstream infections that can cause death. Synthetic antimicrobial peptides (SAMPs) considered to be new weapons combat these infections, alone or combined with drugs. Here, two SAMPs, called Mo-CBP3-PepI Mo-CBP3-PepIII, were tested nystatin (NYS) itraconazole (ITR) against biofilms. Furthermore, the mechanism of antibiofilm activity was evaluated by fluorescence scanning electron microscopies. When results revealed a...
Cryptococcus neoformans is the pathogen responsible for cryptococcal pneumonia and meningitis, mainly affecting patients with suppressed immune systems. We have previously revealed mechanism of anticryptococcal action synthetic antimicrobial peptides (SAMPs). In this study, computational experimental analyses provide new insights into mechanisms SAMPs. Computational analysis that interacted PHO36 membrane receptor C. neoformans. Additionally, ROS (reactive oxygen species) overproduction,...
Staphylococcus aureus is a human pathogen known to be resistant antibiotics since the mid-20th century and constantly associated with hospital-acquired infections. S. forms biofilms, which are complex surface-attached communities of bacteria held together by self-produced polymer matrix consisting proteins, extracellular DNA, polysaccharides. Biofilms resistance structures responsible for increasing bacterial drugs 1000 times more than planktonic lifestyle. Therefore, studies have been...
Klebsiella pneumoniae is a multidrug-resistant opportunistic human pathogen related to various infections. As such, synthetic peptides have emerged as potential alternative molecules. Mo-CBP3-PepI has presented great activity against K. by presenting an MIC50 at very low concentration (31.25 µg mL−1). Here, fluorescence microscopy and proteomic analysis revealed the alteration in cell membrane permeability, ROS overproduction, protein profile of cells treated with Mo-CBP3-PepI. led...
Cancer resistance to drugs and chemotherapy is a problem faced by public health systems worldwide. Repositioning antimicrobial peptides could be an efficient strategy overcome that problem. This study aimed at repurposing PepGAT PepKAA for cancer treatment. After screening against several cancers, presented IC50 values of 125.42 40.51 μM 72 h toward colorectal (CRC) cells. The mechanisms action revealed both induced cell cycle arrest in G2/M drove HCT-116 cells death triggering apoptosis....
Aim: This study aimed to analyze the phylogenetic relationships between ACE2 of humans and other animals investigate potential interaction SARS-CoV-2 RBD different species. Materials & methods: The construction molecular interactions were assessed using computational models. Results conclusion: Despite evolutionary distance, 11 species had a perfect fit for their ( Chinchilla lanigera, Neovison vison, Rhinolophus sinicus, Emballonura alecto, Saccopteryx bilineata, Numida meleagris)....
Abstract NRH:quinone reductase (QR2) is present in the retinas of embryonic and post‐hatched (PH) chicks. 5‐Methoxycarbonylamino‐N‐acetyltryptamine (5‐MCA‐NAT) a QR2 ligand that increases cAMP levels developing retinas, but it does not affect CHO‐QR2 cells. The dopamine quinone activity retrieves dopamine, which retinas. objective study was to investigate whether 5‐MCA‐NAT endogenous from chick embryos Endogenous measured by enzyme‐linked immunosorbent assay (ELISA). increased retinal at all...