A5020842186- Phytochemistry Medicinal Plant Applications
- Essential Oils and Antimicrobial Activity
- Agricultural and Food Sciences
- Synthesis and biological activity
- Piperaceae Chemical and Biological Studies
- Insect Pest Control Strategies
- Hepatitis B Virus Studies
- Child Nutrition and Water Access
- Parasites and Host Interactions
- Phytochemical compounds biological activities
- Neonatal Health and Biochemistry
- Parasitic Infections and Diagnostics
- Psidium guajava Extracts and Applications
- Quinazolinone synthesis and applications
- Synthesis and Characterization of Heterocyclic Compounds
- Drug Transport and Resistance Mechanisms
- Parasite Biology and Host Interactions
- Hemoglobinopathies and Related Disorders
- HIV, Drug Use, Sexual Risk
- Hepatitis C virus research
- Natural Antidiabetic Agents Studies
- Cervical Cancer and HPV Research
- Genital Health and Disease
- Cancer Mechanisms and Therapy
- Cancer-related gene regulation
Universidade Federal do Pará
2015-2024
Universidade da Amazônia
2019-2024
Faculdade Metropolitana de Manaus
2019-2022
Fundação Hemopa
2013
University of Florence
2013
The present study aimed to investigate the effects of MBZ on a human malignant ascites cell line derived from primary gastric cancer tumor. Our data reveal that showed high cytotoxicity in vitro, displaying an IC50 0.39 μM and 1.25 ACP-02 ACP-03, respectively. association between 5-FU increased slightly when compared alone. Furthermore, disrupted microtubule structure AGP-01 cells inhibited significantly invasion migration these cells. Activity active MMP-2 decreased at all tested...
Abstract BACKGROUND Previous studies have recorded a high prevalence of intestinal parasites in lettuce ( Lactuca sativa L . ) and coriander Coriandrum sativum L.) destined for human consumption. This study determined the contamination by these two plants sold street markets supermarkets city Belém, northern Brazil. RESULTS A total 200 plant samples were analyzed (100 each species). The collected randomly between August October 2018, examined spontaneous sedimentation method with washes,...
This work analyzed the chemical compositions and evaluated antioxidant cytotoxic activities of essential oils (EO) Eugenia patrisii (Epat), stipitata (Esti), Myrcia splendens (Mspl), sylvatica (Msyl), Psidium guajava (Pgua), guineense (Pgui-1 Pgui-2) from Brazilian Amazon. Sesquiterpenoids were found in high concentrations E. M. splendens, which rich E-caryophyllene (32.0% 45.8%); sylvatica, displayed germacrene D (11.8%) B (24.5%); P. that showed epi-β-bisabolol (16.1%) as main compound....
To evaluate the impact of HPV immunization and possible changes in virus type-specific prevalence associated with cervical cancer, it is important to obtain baseline information based on socioeconomic, educational, environmental characteristics human populations. We describe these distribution 1,183 women diagnosed cancer two Brazilian healthcare institutions located at Southeastern (Rio de Janeiro/RJ) Amazonian (Belém/PA) regions. Large differences were observed between regions regarding...
Os pesticidas organoclorados (PCOs) são poluentes orgânicos persistentes (POPs) que constituem uma grande fonte de contaminação da água, solo e ar. A exposição humana a eles pode ser um fator risco para diabetes mellitus tipo 2 (DM2), sendo essa associação atribuída mecanismos ação dos PCOs possivelmente influenciam na homeostase glicose. O objetivo do presente estudo é realizar revisão sistemática descritiva literatura sobre detecção água à esses com o DM2. busca artigos foi realizada março...
Currently, sharing of drug paraphernalia is the main form HCV transmission worldwide. In South America, consistent findings indicate that shared sniffing equipment an important factor in spread among non-injecting users. Epidemiological data on status infection illicit users Amazon region are scarce, although reports clinical cases hepatitis or pathologies associated with other population groups numerous. Thereby, this study investigated prevalence, genotype frequency, and epidemiological...
With the aim of discovering new anticancer agents, we have designed and synthesized novel 6-hydroxy-benzo[d][1,3]oxathiol-2-one Schiff bases. The synthesis started with selective nitration at 5-position 6-hydroxybenzo[d][1,3]oxathiol-2-one (1) leading to nitro derivative 2. group 2 was reduced give amino intermediate 3. bases 4a–r were obtained from coupling reactions between 3 various benzaldehydes heteroaromatic aldehydes. All compounds fully identified characterized by NMR (1H 13C)...
Piper aequale Vahl is a small shrub that grows in the shadow of large trees Carajás National Forest, Municipality Parauapebas, Para state, Brazil. The local people have used plant against rheumatism and inflammation. essential oil aerial parts was extracted analyzed by GC GC-MS. MTT colorimetric assay to measuring cytotoxic activity human cancer lines. determination antioxidant conducted DPPH radical scavenging assay. main constituents were δ-elemene (18.92 %), β-pinene (15.56 α-pinene...
Ischemic stroke is one of the principal causes morbidity and mortality around world. The pathophysiological mechanisms that lead to formation lesions range from bioenergetic failure cells intense production reactive oxygen species neuroinflammation. fruit açaí palm, Euterpe oleracea Mart. (EO), consumed by traditional populations in Brazilian Amazon region, it known have antioxidant anti-inflammatory properties. We evaluated whether clarified extract EO was capable reducing area lesion...
The present study aimed to investigate whether MBZ down-regulates drug transporter expression (ABCB1, ABCC1, SLC47A1). mRNA level of ABCB1, ABCC1 and SLC47A1 was evaluated by qPCR protein levels MDR-1 performed western blotting in malignant ascites cells (AGP-01) treated with for 24h. ABCB1 significantly decreased at a 1.0μM compared negative control, while extremely all tested concentrations MBZ. Protein control. Therefore, our results showed may play an important role inhibiting MDR gene cells.
No início de 1996, pesquisadores do Programa Pobreza e Meio Ambiente na Amazônia visitaram as aldeias Kayapó A'Ukre Pykanu no sul estado Pará - Brasil. Essas expedições também objetivaram resgatar a tradição fitoterapêutica kayapó identificar espécies vegetais com potencial farmacêutico. Os pajés apresentaram cinqüenta três diferentes, dos quais vinte tiveram sua identificação botânica elucidada base em fotografias.
The Aedes aegypti mosquito is one of the major vectors arboviruses. These diseases have re-emerged and insecticides used nowadays are toxic to mammals environment only been effective in short-term. In this context, natural products an alternative. genus Piper has many active compounds against arthropods, including neolignans. present study evaluated larvicidal potential n-hexanic extract solmsianum eupomatenoid-6, identified by GC-MS NMR techniques, from Ae. aegypti. crude (100 μg/mL) killed...
OBJETIVOS: Estimar a prevalência de anemia associada parasitoses intestinais, assim como identificar os parasitos mais frequentes, faixa etária acometida e fatores relacionados ao desenvolvimento.