Objective: Intraocular pressure has always been a great challenge for topical ophthalmic drugs. The study aimed to develop ocular surfactant based nanovesicles (NVs) carried in mucoadhesive nanogel providing efficient delivery of acetazolamide (ACZ). Methods: For the sake optimizing formulation parameters, effect type edge activator and its ratio sorbitan monostearate (Span 60) on mean particle size, entrapment efficiency (%EE), zeta potential (ZP) produced NVs was investigated. Results:...

Nanocapsules can be equated to other nanovesicular systems in which a drug is entrapped void containing liquid core surrounded by coat. The objective of the present study was investigate potential polymeric and lipid nanocapsules (LNCs) as innovative carrier for miconazole nitrate (MN) topical delivery. Polymeric LNCs were prepared using emulsification/nanoprecipitation technique where effect poly(ε-caprolactone (PCL) matrix concentrations with respect MN assessed. resulted examined their...

Dacomitinib (DM), a newly FDA-approved chemotherapeutic agent, demonstrates remarkable selectivity in combating non-small cell lung cancer (NSCLC) and hindering its fierce metastasis. The study intended to engineer pH-triggered drug-release PEGylated...

Despite high efficiency of domperidone (DOM) in prophylaxis emesis accompanied with radiotherapy and chemotherapy, it still can bother cancer patients by its powerful side effects difficulty oral administration. The study was designed to develop optimize DOM loaded ethosomal gel for rectal transmucosal delivery. Ethosomal formulations were prepared using a 21, 51 full-factorial design where the impact lecithin concentration additives investigated. optimum vesicles subsequently incorporated...

Abstract The combination of herbal drugs with a topical antibacterial for managing chronic disease like acne vulgaris has emerged lately to settle side effects and bacterial multidrug resistance. Mixed micelles (MMs) incorporated into nanogel were explored hybrid delivery curcumin (Cur) fusidic acid (FA) presenting multi-strategic treatment. Curcumin-fusidic acid–loaded mixed (Cur-FA-MMs) assessed size, surface charge, compatibility, in vitro release, encapsulation. selected formula was...

The encapsulation of pesticides within nanoparticles is a promising approach advanced technology in sustainable agriculture. Lambda-cyhalothrin (LC) was encapsulated by the ionotropic gelation technique into chitosan (CS)/tripolyphosphate (TPP) and CS/alginate (ALG) matrixes. CS-LC were characterized, their efficacy then evaluated against key pest soft fruits Europe United States, Drosophila suzukii. efficiency (74%), nanoparticle yield (80%), polydispersity index (0.341), zeta potential...

Febuxostat (FBX), a potent xanthine oxidase inhibitor, is widely used as blood uric acid-reducing agent and has recently shown promising repurposing outcome an anti-cancer. FBX known for its poor water solubility, which the main cause of weak oral bioavailability. In previous study, we developed binary system complex between sulfobutylether-β-cyclodextrin (SBE7-βCD) with improved dissolution behavior. The aim current study was to investigate effect incorporating water-soluble polymer forming...

This work aimed to synthesize surfactant-free AuNPs for targeted delivery of plasmid DNA encoded p53 gene and avoid conventional production method Gold nanoparticles (AuNPs) which may adversely affect the final shape, diversity, size due accumulation formulated surfactant - gold complex surface.The were fabricated using seeded-growth with L-Cystine methyl ester hydrochloride as capping agent, then loaded gene. The resultant AuNPs-p53 evaluated physical characteristics morphology....

For the sake of improving patient compliance and sustainability chemotherapy healthcare system, both TC CoQ10 were formulated as solid lipid nanoparticles (SLNs). The study was focused on establishing validating a simple reproducible spectrophotometric method for simultaneous determination in their binary mixture or pharmaceutical dosage forms. A new based estimation drug without prior separation developed. Validation parameters checked with International Conference Harmonization (ICH)...

Objective: The development of nanosuspension for targeted delivery glibenclamide as hypoglycemic agent to the lung in an inhaler dosage form.Method: Glibenclamide formulations were prepared using Box–Behnken design investigate effect independent factors on dependent variables, Fourier-transform Infrared spectroscopy, Differential Scanning Calorimetry, evaluation and vivo efficacy performed determine effect.Results: results revealed that mean particle sizes ranged from 0.216 0.856 µm, zeta...

The aim of this research was the development and optimization nanoniosomes for delivery glibenclamide (Gbn) as hypoglycaemic agent to lung in an inhaler dosage form. Fifteen formulae niosomal dispersions were prepared according Box-Behnken design. effect drug amount, Cholesterol molar ratio, Hydrophilic lipophilic balance (HLB) values surfactant on mean vesicle size, Zeta potential (ZP), polydispersity index (PDI), entrapment efficiency, in-vitro released Gbn investigated. A quality control...

Background:Curcumin is an important natural compound that has been extensively studied for its multifunctional pharmacological activities.Different nanotechnological techniques have applied improving poor solubility and bioavailability.Objectives: This research aimed to study the effect of formulation variables on entrapment efficiency curcumin-loaded niosomes (curcusomes) made by a thin-film hydration technique.Methods: Curcumin-loaded noisome were prepared using technique Span 40 60 as...

incorporating aqueous solutions into hard gelatin capsules (HGCs) without dispersing them in an oily medium is considered a challenge for most researchers and manufacturers. The aim of the study to evaluate effect gamma radiation (ɣ-radiation) on adaptation HGCs solution delivery. Methods: Empty HGC shells were exposed four ɣ-radiation doses (1, 3, 5, 10 kGy). Then, physicochemical properties irradiated evaluation compared with those non-irradiated capsules.