A5101768684- Advanced Chemical Physics Studies
- Atmospheric Ozone and Climate
- Genomics and Phylogenetic Studies
- Spectroscopy and Laser Applications
- SARS-CoV-2 and COVID-19 Research
- Bacteriophages and microbial interactions
- Hepatitis C virus research
- Plant-Microbe Interactions and Immunity
- Metabolism and Genetic Disorders
- Genetic diversity and population structure
- Hemoglobinopathies and Related Disorders
- Epigenetics and DNA Methylation
- Cancer Genomics and Diagnostics
- Enzyme Production and Characterization
- Gene expression and cancer classification
- Nanofluid Flow and Heat Transfer
- Chemical Synthesis and Analysis
- Ginger and Zingiberaceae research
- Piperaceae Chemical and Biological Studies
- Cardiomyopathy and Myosin Studies
- DNA Repair Mechanisms
- Atomic and Molecular Physics
- Identification and Quantification in Food
- Computational Drug Discovery Methods
- Genetic Associations and Epidemiology
University of Karachi
2016-2025
International Center for Chemical and Biological Sciences
2016-2025
Research International (United States)
2024
Lahore University of Management Sciences
2024
University of Warsaw
2024
Dow University of Health Sciences
2024
National Institute of Health Sciences
2024
Bridge University
2024
Abdul Wali Khan University Mardan
2023
Riphah International University
2023
β-Thalassemia is one of the most prevalent forms congenital blood disorders characterized by reduced hemoglobin levels with severe complications, affecting all dimensions life. The mechanisms underlying phenotypic heterogeneity β-thalassemia are still poorly understood. We aimed to work over metabolite biomarkers improve mechanistic understanding and hence better management disorder at different levels. Untargeted serum metabolites were analyzed after protein precipitation SPE (solid phase...
Herein, we reported mutations in five DNA Damage Repair (DDR) i.e., TP53, ATR, ATM, CHEK1 and CHEK2 involved OSCC using NG-WES their analysis bioinformatics tools. Out of 42 identified mutations, 16.7% are for the 1st time. A total 28 nonsynonymous SNVs identified. TP53 harbored highest number followed by CHEK2. Nine (TP53p.R43H, TP53p.L125Q, TP53p.R116Q, TP53p.C110Y, TP53p.L62F, ATRp.H120Y, ATMp.P1054R, ATMp.D1853V, ATMp.T2934N) were predicted highly pathogenic. SAAFEQ-SEQ destabilizing...
Abstract Background Acute myeloid leukemia (AML) is a blood malignancy that develops in the bone marrow due to uncontrolled cell proliferation and undifferentiating cells. This fast-progressing cancer has higher percentage of relapses clonal evolution re-emergence resistant clones. Identification relapse associated genetic elements AML remains challenge. In this prospective study, whole-exome sequencing was performed newly diagnosed cytogenetically normal AML. The patients treated with 7 + 3...
Farsetia hamiltonii Royle is a medicinally important annual plant from the Cholistan desert that belongs to tribe Anastaticeae and clade C of Brassicaceae family. We provide entire chloroplast sequence F.hamiltonii, obtained using Illumina HiSeq2500 paired-end sequencing. compared F. nine other species, including occidentalis, Lobularia libyca, Notoceras bicorne, Parolinia ornata, Morettia canescens, Cochlearia borzaeana, Megacarpaea polyandra, Biscutella laevigata, Iberis amara. conducted...
The nanoliquid concept has variety of applications toward biomedicine, heat exchangers, cooling electrical devices, foods, and transportation. It is important to add various kinds solid nanoparticles, such as silica, copper, silver, alumina, graphene, gold, so on the base fluids increase thermal efficiency common like engine oil, kerosene water, sodium alginate, etc. This research explores second-order slip flow a Cu-Fe 3 O 4 /H 2 past bi-directional stretching surface. current takes into...
Augmentation of fetal hemoglobin (HbF) production has been an enduring therapeutic objective in β-thalassemia patients for which hydroxyurea (HU) largely the drug choice and most cost-effective approach. A serum metabolomics study on 40 with prior to after administration HU was done along healthy controls. Treated were divided further into non-responders (NR), partial (PR) good (GR) per their response. 25 metabolites that altered before therapy at p ≤ 0.05 fold change >2.0 patients; started...
Virtual screening of an in-house virtual library synthetic compounds using FlexX, followed by enzyme inhibition, identified hydrazide and hydrazine derivatives as novel aspartic protease inhibitors. These inhibited human cathepsin D Plasmodium falciparum plasmepsin-II with low micromolar concentrations (IC(50) = 1-2.5 microM). Modelling studies predicted binding ligands at the centre extended substrate-binding cleft, where hydrazide/hydrazine parts inhibitors acted transition state mimic...
Food adulteration is a serious concern faced by the importers of various food products across globe. In this study, simple, sensitive and robust method for detecting pork in processed/complex samples using next-generation DNA sequencing (NGS) technology described. The experimentation involves generalized library preparation kit performing shotgun genomic irrespective its intactness. was applied on different complex containing along with other species (up to twelve) as well without test...
Heart Failure (HF) is a complex clinical syndrome in which the heart unable to provide enough blood flow meet metabolic needs and lacks efficient venous return. HF major risk factor for morbidity mortality with cardiovascular diseases globally. Despite enormous research, molecular markers relevant disease prognosis management remain not well understood. Here, we analyzed whole transcriptomes of 18 failing hearts 15 non-failing (predominantly Caucasian origin), by applying standard silico...
Climate change is becoming a global problem because of its harmful effects on crop productivity. In this regard, it crucial to carry out studies determine crops' response heatwave stress. Response molecular mechanisms during the development and ripening mango fruit (Mangifera indica L. cv. Chaunsa White) under extreme heatwaves were studied. Mango flowers tagged fruits 18, 34, 62, 79, 92 days after flowering (DAF) as well 10 15 postharvest shelf life studied through RNA-Seq metabolome...
Chloroplast is an important cellular organelle of autotrophs which has independent, circular, doublestranded DNA molecule termed as chloroplast genome. The (cpDNA) contains essential genes for its maintenance and operation. Several components the photosystems proteins involved in biosynthetic pathways are also encoded by Exploring genetic repository this vital due to conserved nature, small size, persistent gene organization promising ability transgenic expression. Therefore, cpDNA sequence...
To determine students' perception of bedside teaching, to find out barriers in its effective implementation and suggest strategies make it an learning tool.This study was conducted Faculty Medicine, Northern Border University Arar, Kingdom Saudi Arabia between November 2013 January 2014. The design qualitative inductive thematic analysis using transcripts from audio-recorded focus group discussions. Four focused discussions with medical students 4(th) 5(th) year MBBS were conducted. Each 40...