A5087960527- Hemoglobinopathies and Related Disorders
- Erythrocyte Function and Pathophysiology
- Blood groups and transfusion
- COVID-19 Clinical Research Studies
- Chronic Lymphocytic Leukemia Research
- Iron Metabolism and Disorders
- Platelet Disorders and Treatments
- Acute Myeloid Leukemia Research
- Blood disorders and treatments
- Complement system in diseases
- Long-Term Effects of COVID-19
- Venous Thromboembolism Diagnosis and Management
- Extracellular vesicles in disease
- Folate and B Vitamins Research
- Mosquito-borne diseases and control
- CRISPR and Genetic Engineering
- Liver Disease Diagnosis and Treatment
- Diverse Scientific Research Studies
- Health and Well-being Studies
- Lymphoma Diagnosis and Treatment
- Blood Coagulation and Thrombosis Mechanisms
- Multiple Myeloma Research and Treatments
- Immunodeficiency and Autoimmune Disorders
- Thermal Regulation in Medicine
- Viral Infections and Vectors
Jazan University
2019-2024
RMIT University
2017-2019
The Bruton's tyrosine kinase (Btk) inhibitor ibrutinib has proven to be efficacious in the treatment of B-cell chronic lymphocytic leukemia (B-CLL) and related diseases. However, a major adverse side effect is bleeding, including hemorrhages. bleeding associated with use thought due combination on-target irreversible Btk inhibition, as well off-target inhibition other kinases, EGFR, ITK, JAK3, Tec kinase. In this study, we investigated effects vs zanubrutinib (a more selective inhibitor) on...
Both nilotinib, a second-generation tyrosine kinase inhibitor (TKI) used in the treatment of chronic myeloid leukaemia (CML), and ponatinib, third-generation TKI CML Philadelphia positive acute lymphocytic leukaemia, have been associated with an increase arterial occlusive events, contrast to other TKIs such as imatinib dasatinib. We previously demonstrated evidence pro-thrombotic state using microvascular thrombosis C57BL/6 mouse models. In this study, we examined ponatinib determined if...
Background: Nutritional anemia is a significant public health concern worldwide, particularly affecting young adults and children in Saudi Arabia, where inadequate nutrition considered primary contributing factor.This study aims to (i) examine the levels of serum iron, folate, vitamin B 12 adult students, with focus on identifying any deficiencies their association anemia; (ii) explore prevalence mixed-deficiency resulting from (iii) how sociodemographic characteristics dietary habits...
The hypercoagulability and thrombotic tendency in coronavirus disease 2019 (COVID-19) is multifactorial, driven mainly by inflammation, endothelial dysfunction. Elevated levels of procoagulant microvesicles (MVs) tissue factor-bearing (TF-bearing MVs) have been observed many diseases with tendency. current study aimed to measure the MVs TF-bearing patients COVID-19 healthy controls correlate their platelet counts, D-Dimer levels, other proposed calculated inflammatory markers.Forty...
Purpose: Anemia is one of the most common disorders affecting population in both low-income and developing countries. This study aimed to determine prevalence anemia iron deficiency apparently normal male female students Jazan University, Saudi Arabia. Material Methods: cross-sectional was conducted at Faculty Applied Medical Sciences, Gizan, One hundred thirty-four (85 males 49 females) healthy with no outward signs illness were recruited. A specific questionnaire related sociodemographic...
Sickle cell disease (SCD) and thalassemia are common inherited blood disorders in Saudi Arabia, especially Jazan Province. Patients with these require multiple transfusions, which may lead to alloimmunization because of mismatched group antigens. In this study, we examined the autoimmunization rates patients SCD together involved antibodies.A cross-sectional study was conducted review transfusion history records at Prince Mohammed bin Nasser Hospital, Province, Arabia.Four-hundred...
Abstract Background and aim Despite the fact that chikungunya viral infection is a neglected disease, complications such as hemorrhagic fever, arthritis, lymphopenia remain health concern. The of this study was to determine prevalence virus in Southern Region, Saudi Arabia. Enzyme immunoassay polymerase chain reaction have been compared between samples. Materials methods Forty samples from two southern hospitals Arabia were collected December 2019 February 2020 screened for IgG antibodies...
Transfusion-transmitted infectious agents are amongst the major health burden worldwide. The purpose of this study was to evaluate prevalence hepatitis B virus (HBV), C (HCV), and human immunodeficiency (HIV) among blood donors in Samtah General Hospital, Jazan region, Saudi Arabia.In retrospective study, donation records all recruited between January 2019 August 2020 were included for data acquisition. A total 4977 donors' reviewed analysed.Hepatitis profile showed 0.60% positive hepatis...
Purpose: Knowledge of the prevalence blood group antigens in a given population is important for prevention hemolytic reactions. The MNS system (002) has four polymorphic antigens—M, N, S, and s. Anti-S anti-s antibodies may result immediate delayed transfusion reactions, disease fetus newborn occur. present study investigated frequencies main phenotypes system. Subjects Methods: We randomly obtained 149 samples from anonymous Saudi donors living Jazan Province. Serotyping was conducted...
Male contribution towards couple infertility is increasing but less discussed. We aimed to assess the knowledge about iron deficiency anemia (IDA) as a contributor male in students at health colleges of Jazan University. A multicentric, cross-sectional survey included 910 participants and 768 qualified per our inclusion criteria. The questions were categorized as: Model 1-knowledge IDA-induced infertility; 2-knowledge IDA. average IDA causing very low among students. 18-20 years age group...
The aims of the current study were to evaluate importance MPR and NLR as prognostic markers in ICU-admitted COVID-19 patients investigate impact on hematological coagulation parameters from Jazan region Saudi Arabia.This retrospective was conducted between October 2020 January 2021 at King Fahad Central Hospital, region. Medical files, which included results complete blood count (CBC), calculated mean platelet volume ratio (MPR) neutrophils-to-lymphocytes (NLR) parameters, profile D-dimer...
Procoagulant microvesicles (MVs) are submicron membrane fragments released from activated cells and undergoing apoptosis. The procoagulant activity of MVs is enhanced in the presence tissue factor (TF). TF active mediators that induce pro-inflammatory response prothrombotic tendency have been linked to severity several disorders, including malaria infection. current study aimed measure levels circulating TF-bearing patients correlate these with other hematological parameters...
Background: Diabetes mellitus (DM) is a major health burden affecting 537 million adults worldwide, characterized by chronic metabolic disorder and various complications. This case control study aimed to assess the impact of type 2 diabetes (T2DM), including hyperglycemia levels, on hematological parameters complete blood count (CBC) derived parameters. Methods: A total 250 known diabetic patients from Jazan Diabetic Center, Saudi Arabia, between January 2021 December 2022, along with 175...
Studies of risk factors are especially valuable at this difficult time in the midst a pandemic. High levels particulate matter (PM) represent serious factor on health. While is direct impact health, indirect effects worth considering, too.The aim study was to investigate role PM transmission viruses, SARS-CoV-2. Also, we sought understand dynamics still air high and low altitudes. Historic AQI physical measurements were collected between August September 2020 using quality detector....
Glutathione S-transferases (GSTT1 and GSTM1) detoxify various endogenous exogenous compounds provide cytoprotective role against reactive species. This study aimed to assess the frequency of GSTT1, GSTM1 polymorphisms in newly diagnosed Sudanese adult patients with acute lymphoblastic leukemia (ALL) evaluate association these age, gender type ALL.This case-control included 128 Sudanese, untreated ALL, aged 18 74 years age-gender matched healthy controls. Deletional GSTT1 genes were genotyped...
The Dombrock (DO) blood group system has two primary antigens, Doa and Dob, which can cause delayed hemolytic transfusion reactions. paucity of specific monospecific antibodies hamper the typing based on these antigens. Thus, genotyping (BGG) was investigated as a possible solution. Sequence-specific primers were designed to target single nucleotide polymorphism (rs11276) ART4 gene encoding DO*A DO*B alleles. Blood samples (n = 150) from randomly selected volunteer donors used. DNA extracted...
Background: The levels of procoagulant microvesicles (MVs) and tissue factor (TF)-bearing MVs may be increased in many conditions, including dengue fever (DF). This study aimed to measure the TF-bearing patients with DF matched healthy controls. Materials & methods: Levels plasma controls were measured using functional assay. Results: patient group had significantly elevated (p < 0.001) slightly = 0.454) compared Conclusion: Elevated could used as biomarkers evaluate hemostatic function DF.
Background: Glucose-6-phosphate dehydrogenase (G6PD) deficiency anemia is the most common metabolic red cell abnormality worldwide. G6PD very in Saudi Arabia. Objective: The aims of current study were to evaluate and assess knowledge awareness about find any association between sociodemographic variables this disease population Jazan region. Materials Methods: A cross-sectional descriptive was conducted at University. Results: total 709 individuals completed questionnaire considered study....
Abstract: The genome editing approach by clustered regularly interspaced short palindromic repeats (CRISPR)/associated protein 9 (CRISPR/Cas9) is a revolutionary advancement in genetic engineering. Owing to its simple design and powerful genome-editing capability, it offers promising strategy for the treatment of different infectious, metabolic, diseases. crystal structure Streptococcus pyogenes Cas9 (SpCas9) complex with sgRNA target DNA at 2.5 Å resolution reveals groove accommodating...
Anemia, particularly iron deficiency anemia (IDA), is a prevalent health issue globally and in Saudi Arabia, especially among young adult females. This study investigates the association between academic achievement female students at Female Health Campus of Jazan University, Jazan, Arabia. cross-sectional included 118 randomly selected participants aged 18–22. A validated questionnaire was administered to participants. The underwent blood tests for complete count (CBC) parameters profile...
Folic acid (FA) plays a crucial role in various biological processes. Insufficient intake of FA during pregnancy can lead to serious clinical complications, including neural tube defect. The current study sought assess the awareness, knowledge, and usage among young females Jazan region Saudi Arabia. This cross-sectional descriptive involved 472 adult from October 1 9, 2023, region, questionnaire was randomly distributed females. data showed that awareness supplementation were poor fair...